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Biology and Biochemistry
France
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
89
Citations
21567
World Ranking
2628
National Ranking
58

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in France Leader Award

Overview

Rob W.H. Ruigrok is affiliated with Grenoble Alpes University in France. Their research primarily focuses on biochemistry, genetics, and molecular biology, with significant contributions also in medicine. The subfields of study include molecular biology, epidemiology, infectious diseases, public health, environmental and occupational health, and immunology.

The scientist's main topics of research encompass:

  • RNA modifications and cancer
  • RNA research and splicing
  • RNA and protein synthesis mechanisms
  • Influenza virus research studies
  • Nuclear structure and function
  • Virology and viral diseases
  • Interferon and immune responses

Rob W.H. Ruigrok has published research in journals such as Science Advances, Journal of the American Chemical Society, Journal of Molecular Biology, Viruses, and Current Opinion in Virology. The frequent publication venues include:

  • Science Advances
  • Journal of the American Chemical Society
  • Journal of Molecular Biology
  • Viruses
  • Current Opinion in Virology

Some of the recent papers authored or co-authored by Ruigrok include:

  • Measles virus nucleo- and phosphoproteins form liquid-like phase-separated compartments that promote nucleocapsid assembly (2020, Science Advances)
  • The intrinsically disordered SARS-CoV-2 nucleoprotein in dynamic complex with its viral partner nsp3a (2022, Science Advances)
  • Liquid-Liquid Phase Separation Modifies the Dynamic Properties of Intrinsically Disordered Proteins (2023, Journal of the American Chemical Society)
  • Structure, dynamics and phase separation of measles virus RNA replication machinery (2020, Current Opinion in Virology)
  • Cryo-EM structure of influenza helical nucleocapsid reveals NP-NP and NP-RNA interactions as a model for the genome encapsidation (2023, Science Advances)

Key frequent co-authors with whom Ruigrok has collaborated include:

  • Thibaut Crépin
  • Martin Blackledge
  • Damien Maurin
  • Serafima Guseva
  • Malene Ringkjøbing Jensen

Best Publications

  • The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit

    Alexandre Dias;Denis Bouvier;Thibaut Crépin;Andrew A. McCarthy

  • The Structural Basis for CAP Binding by Influenza Virus Polymerase Subunit Pb2.

    Delphine Guilligay;Franck Tarendeau;Patricia Resa-Infante;Rocío Coloma

  • A structural model for unfolded proteins from residual dipolar couplings and small-angle x-ray scattering

    Pau Bernadó;Laurence Blanchard;Peter Timmins;Dominique Marion

  • Structural insight into cap-snatching and RNA synthesis by influenza polymerase

    Stefan Reich;Delphine Guilligay;Alexander Pflug;Hélène Malet

  • Structure and Nuclear Import Function of the C- Terminal Domain of Influenza Virus Polymerase Pb2 Subunit

    Franck Tarendeau;Julien Boudet;Delphine Guilligay;Philippe J Mas

  • The 2.2 A resolution crystal structure of influenza B neuraminidase and its complex with sialic acid.

    W. P. Burmeister;R. W. H. Ruigrok;S. Cusack

  • Crystal Structure of the Rabies Virus Nucleoprotein-RNA Complex

    Aurélie A. V. Albertini;Amy K. Wernimont;Tadeusz Muziol;Raimond B. G. Ravelli

  • Structure of influenza virus RNP. I. Influenza virus nucleoprotein melts secondary structure in panhandle RNA and exposes the bases to the solvent.

    F. Baudin;C. Bach;S. Cusack;R. W. H. Ruigrok

  • Nuclear traffic of influenza virus proteins and ribonucleoprotein complexes.

    Sébastien Boulo;Hatice Akarsu;Rob W.H. Ruigrok;Florence Baudin

  • Heparan sulfate-mediated binding of infectious dengue virus type 2 and yellow fever virus.

    Raphaële Germi;Jean-Marc Crance;Daniel Garin;Josette Guimet

  • Crystal structure of the M1 protein-binding domain of the influenza A virus nuclear export protein (NEP/NS2)

    Hatice Akarsu;Hatice Akarsu;Wilhelm P. Burmeister;Wilhelm P. Burmeister;Carlo Petosa;Isabelle Petit

  • Nucleoproteins and nucleocapsids of negative-strand RNA viruses.

    Rob W H Ruigrok;Thibaut Crépin;Dan Kolakofsky

  • Roles of the influenza virus polymerase and nucleoprotein in forming a functional RNP structure.

    Klaus Klumpp;Rob W.H. Ruigrok;Florence Baudin

  • Membrane fusion by peptide analogues of influenza virus haemagglutinin.

    S. A. Wharton;S. R. Martin;R. W. H. Ruigrok;J. J. Skehel

  • Influenza A Virus Polymerase: Structural Insights into Replication and Host Adaptation Mechanisms

    Stéphane Boivin;Stephen Cusack;Rob W. H. Ruigrok;Darren J. Hart

  • Rabies virus glycoprotein is a trimer

    Yves Gaudin;Rob W.H. Ruigrok;Christine Tuffereau;Marcel Knossow

  • Describing intrinsically disordered proteins at atomic resolution by NMR.

    Malene Ringkjøbing Jensen;Rob W H Ruigrok;Martin Blackledge

  • Ebola virus matrix protein VP40 interaction with human cellular factors Tsg101 and Nedd4.

    Joanna Timmins;Guy Schoehn;Sylvie Ricard-Blum;Sandra Scianimanico

  • Paramyxovirus mRNA editing, the "rule of six" and error catastrophe: a hypothesis.

    Daniel Kolakofsky;Laurent Roux;Dominique Garcin;Rob W. H. Ruigrok

  • In Vitro Dissection of the Membrane and RNP Binding Activities of Influenza Virus M1 Protein

    Florence Baudin;Isabelle Petit;Winfried Weissenhorn;Rob W.H. Ruigrok

Frequent Co-Authors

Guy Schoehn
Guy Schoehn Grenoble Alpes University
Stephen Cusack
Stephen Cusack European Bioinformatics Institute
Martin Blackledge
Martin Blackledge Grenoble Alpes University
Winfried Weissenhorn
Winfried Weissenhorn Grenoble Alpes University
Christine Ebel
Christine Ebel Grenoble Alpes University
Jean Gagnon
Jean Gagnon University of Montreal
Yves Jacob
Yves Jacob Institut Pasteur
John J. Skehel
John J. Skehel The Francis Crick Institute
Don C. Wiley
Don C. Wiley Harvard University
Anne Flamand
Anne Flamand Centre national de la recherche scientifique, CNRS

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