What is he best known for?
The fields of study he is best known for:
His main research concerns Neisseria gonorrhoeae, Receptor, Microbiology, Molecular biology and P2Y receptor.
The study incorporates disciplines such as Antibiotic resistance, Drug resistance and Ceftriaxone in addition to Neisseria gonorrhoeae.
Receptor is a subfield of Biochemistry that he tackles.
Many of his research projects under Microbiology are closely connected to MTRR with MTRR, tying the diverse disciplines of science together.
Robert A. Nicholas combines subjects such as Agonist, Purinergic Agonists, Adenylyl cyclase, Nucleotide and Phospholipase C with his study of Molecular biology.
Robert A. Nicholas studied P2Y receptor and G protein that intersect with Rhodopsin-like receptors, G protein-coupled receptor and 5-HT1 receptor.
His most cited work include:
- High-level cefixime- and ceftriaxone-resistant Neisseria gonorrhoeae in France: novel penA mosaic allele in a successful international clone causes treatment failure. (437 citations)
- Uridine nucleotide selectivity of three phospholipase C-activating P2 receptors: identification of a UDP-selective, a UTP-selective, and an ATP- and UTP-specific receptor. (323 citations)
- P2-Purinergic Receptors: Subtype-Associated Signaling Responses and Structure (317 citations)
What are the main themes of his work throughout his whole career to date?
Robert A. Nicholas mainly focuses on Biochemistry, Penicillin binding proteins, Neisseria gonorrhoeae, Receptor and Molecular biology.
In his study, Apical membrane is strongly linked to Cell biology, which falls under the umbrella field of Biochemistry.
His Penicillin binding proteins research is multidisciplinary, incorporating elements of Protein structure, Active site, Stereochemistry and Carboxypeptidase.
His research in Neisseria gonorrhoeae intersects with topics in Cefixime, Antibiotic resistance and Gene.
The concepts of his Receptor study are interwoven with issues in Signal transduction, Adenine nucleotide and Uracil nucleotide.
Robert A. Nicholas has researched Molecular biology in several fields, including 5-HT5A receptor, Enzyme-linked receptor and Complementary DNA.
He most often published in these fields:
- Biochemistry (46.15%)
- Penicillin binding proteins (31.54%)
- Neisseria gonorrhoeae (30.77%)
What were the highlights of his more recent work (between 2013-2021)?
- Neisseria gonorrhoeae (30.77%)
- Genetics (12.31%)
- Antibiotic resistance (10.77%)
In recent papers he was focusing on the following fields of study:
The scientist’s investigation covers issues in Neisseria gonorrhoeae, Genetics, Antibiotic resistance, Penicillin binding proteins and Microbiology.
His Neisseria gonorrhoeae research incorporates elements of Mutation, Bacterial outer membrane, Neisseria and Cell biology.
His work deals with themes such as Family medicine, Clinical trial and Public health, which intersect with Antibiotic resistance.
His Penicillin binding proteins study integrates concerns from other disciplines, such as Protein structure and Active site.
Protein structure is a primary field of his research addressed under Biochemistry.
As a member of one scientific family, Robert A. Nicholas mostly works in the field of Microbiology, focusing on Operon and, on occasion, Efflux.
Between 2013 and 2021, his most popular works were:
- Alanine 501 Mutations in Penicillin-Binding Protein 2 from Neisseria gonorrhoeae: Structure, Mechanism, and Effects on Cephalosporin Resistance and Biological Fitness (24 citations)
- In Vivo-Selected Compensatory Mutations Restore the Fitness Cost of Mosaic penA Alleles That Confer Ceftriaxone Resistance in Neisseria gonorrhoeae (21 citations)
- Diffusion of Antibiotics through the PilQ Secretin in Neisseria gonorrhoeae Occurs through the Immature, Sodium Dodecyl Sulfate-Labile Form (12 citations)
In his most recent research, the most cited papers focused on:
His primary scientific interests are in Neisseria gonorrhoeae, Mutation, Cell biology, Bacterial outer membrane and Mutant.
His Mutation research is multidisciplinary, relying on both Allele and Microbiology.
His work carried out in the field of Allele brings together such families of science as Cefixime, Cephalosporin and Penicillin binding proteins.
His studies deal with areas such as T cell, Dendritic cell, Neisseria and Porin as well as Cell biology.
His study in Bacterial outer membrane is interdisciplinary in nature, drawing from both Pilus, Immune system, Frameshift mutation, Molecular biology and Operon.
His Mutant research includes themes of Periplasmic space, Aconitase and Antibiotic resistance.
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