His main research concerns Neisseria gonorrhoeae, Receptor, Microbiology, Molecular biology and P2Y receptor. The study incorporates disciplines such as Antibiotic resistance, Drug resistance and Ceftriaxone in addition to Neisseria gonorrhoeae. Receptor is a subfield of Biochemistry that he tackles.
Many of his research projects under Microbiology are closely connected to MTRR with MTRR, tying the diverse disciplines of science together. Robert A. Nicholas combines subjects such as Agonist, Purinergic Agonists, Adenylyl cyclase, Nucleotide and Phospholipase C with his study of Molecular biology. Robert A. Nicholas studied P2Y receptor and G protein that intersect with Rhodopsin-like receptors, G protein-coupled receptor and 5-HT1 receptor.
Robert A. Nicholas mainly focuses on Biochemistry, Penicillin binding proteins, Neisseria gonorrhoeae, Receptor and Molecular biology. In his study, Apical membrane is strongly linked to Cell biology, which falls under the umbrella field of Biochemistry. His Penicillin binding proteins research is multidisciplinary, incorporating elements of Protein structure, Active site, Stereochemistry and Carboxypeptidase.
His research in Neisseria gonorrhoeae intersects with topics in Cefixime, Antibiotic resistance and Gene. The concepts of his Receptor study are interwoven with issues in Signal transduction, Adenine nucleotide and Uracil nucleotide. Robert A. Nicholas has researched Molecular biology in several fields, including 5-HT5A receptor, Enzyme-linked receptor and Complementary DNA.
The scientist’s investigation covers issues in Neisseria gonorrhoeae, Genetics, Antibiotic resistance, Penicillin binding proteins and Microbiology. His Neisseria gonorrhoeae research incorporates elements of Mutation, Bacterial outer membrane, Neisseria and Cell biology. His work deals with themes such as Family medicine, Clinical trial and Public health, which intersect with Antibiotic resistance.
His Penicillin binding proteins study integrates concerns from other disciplines, such as Protein structure and Active site. Protein structure is a primary field of his research addressed under Biochemistry. As a member of one scientific family, Robert A. Nicholas mostly works in the field of Microbiology, focusing on Operon and, on occasion, Efflux.
His primary scientific interests are in Neisseria gonorrhoeae, Mutation, Cell biology, Bacterial outer membrane and Mutant. His Mutation research is multidisciplinary, relying on both Allele and Microbiology. His work carried out in the field of Allele brings together such families of science as Cefixime, Cephalosporin and Penicillin binding proteins.
His studies deal with areas such as T cell, Dendritic cell, Neisseria and Porin as well as Cell biology. His study in Bacterial outer membrane is interdisciplinary in nature, drawing from both Pilus, Immune system, Frameshift mutation, Molecular biology and Operon. His Mutant research includes themes of Periplasmic space, Aconitase and Antibiotic resistance.
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High-level cefixime- and ceftriaxone-resistant Neisseria gonorrhoeae in France: novel penA mosaic allele in a successful international clone causes treatment failure.
Magnus Unemo;Daniel Golparian;Robert Nicholas;Makoto Ohnishi.
Antimicrobial Agents and Chemotherapy (2012)
Uridine nucleotide selectivity of three phospholipase C-activating P2 receptors: identification of a UDP-selective, a UTP-selective, and an ATP- and UTP-specific receptor.
Robert A. Nicholas;William C. Watt;Eduardo R. Lazarowski;Qing Li.
Molecular Pharmacology (1996)
P2-Purinergic Receptors: Subtype-Associated Signaling Responses and Structure
T K Harden;J L Boyer;R A Nicholas.
Annual Review of Pharmacology and Toxicology (1995)
Emergence of multidrug-resistant, extensively drug-resistant and untreatable gonorrhea
Magnus Unemo;Robert A Nicholas.
Future Microbiology (2012)
Second messenger cascade specificity and pharmacological selectivity of the human P2Y1-purinoceptor
Joel B. Schachter;Qing Li;José L. Boyer;Robert A. Nicholas.
British Journal of Pharmacology (1996)
Physiological regulation of ATP release at the apical surface of human airway epithelia.
Seiko F. Okada;Robert A. Nicholas;Silvia M. Kreda;Eduardo R. Lazarowski.
Journal of Biological Chemistry (2006)
Expression of a cloned P2Y purinergic receptor that couples to phospholipase C.
T M Filtz;Q Li;J L Boyer;R A Nicholas.
Molecular Pharmacology (1994)
Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms in penA, mtrR, porB1b, and ponA.
Robert Lindberg;Hans Fredlund;Robert Nicholas;Magnus Unemo.
Antimicrobial Agents and Chemotherapy (2007)
Agonist Action of Adenosine Triphosphates at the Human P2Y1 Receptor
R. Kyle Palmer;José L. Boyer;Joel B. Schachter;Robert A. Nicholas.
Molecular Pharmacology (1998)
Mutations in ponA, the Gene Encoding Penicillin-Binding Protein 1, and a Novel Locus, penC, Are Required for High-Level Chromosomally Mediated Penicillin Resistance in Neisseria gonorrhoeae
Patricia A. Ropp;Mei Hu;Melanie Olesky;Robert A. Nicholas.
Antimicrobial Agents and Chemotherapy (2002)
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