Robert A. Nicholas

Overview

Best Publications

• High-level cefixime- and ceftriaxone-resistant Neisseria gonorrhoeae in France: novel penA mosaic allele in a successful international clone causes treatment failure.

  Magnus Unemo;Daniel Golparian;Robert Nicholas;Makoto Ohnishi

  728
  Citations

• Emergence of multidrug-resistant, extensively drug-resistant and untreatable gonorrhea

  Magnus Unemo;Robert A Nicholas

  518
  Citations

• Uridine nucleotide selectivity of three phospholipase C-activating P2 receptors: identification of a UDP-selective, a UTP-selective, and an ATP- and UTP-specific receptor.

  Robert A. Nicholas;William C. Watt;Eduardo R. Lazarowski;Qing Li

  510
  Citations

• P2-Purinergic Receptors: Subtype-Associated Signaling Responses and Structure

  T K Harden;J L Boyer;R A Nicholas

  496
  Citations

• Second messenger cascade specificity and pharmacological selectivity of the human P2Y1-purinoceptor

  Joel B. Schachter;Qing Li;José L. Boyer;Robert A. Nicholas

  354
  Citations

• Physiological regulation of ATP release at the apical surface of human airway epithelia.

  Seiko F. Okada;Robert A. Nicholas;Silvia M. Kreda;Eduardo R. Lazarowski

  266
  Citations

• Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms in penA, mtrR, porB1b, and ponA.

  Robert Lindberg;Hans Fredlund;Robert Nicholas;Magnus Unemo

  260
  Citations

• Expression of a cloned P2Y purinergic receptor that couples to phospholipase C.

  T M Filtz;Q Li;J L Boyer;R A Nicholas

  254
  Citations

• Agonist Action of Adenosine Triphosphates at the Human P2Y1 Receptor

  R. Kyle Palmer;José L. Boyer;Joel B. Schachter;Robert A. Nicholas

  234
  Citations

• Mutations in ponA, the Gene Encoding Penicillin-Binding Protein 1, and a Novel Locus, penC, Are Required for High-Level Chromosomally Mediated Penicillin Resistance in Neisseria gonorrhoeae

  Patricia A. Ropp;Mei Hu;Melanie Olesky;Robert A. Nicholas

  234
  Citations

• Overexpression of the MtrC-MtrD-MtrE Efflux Pump Due to an mtrR Mutation Is Required for Chromosomally Mediated Penicillin Resistance in Neisseria gonorrhoeae

  Wendy L. Veal;Wendy L. Veal;Robert A. Nicholas;William M. Shafer;William M. Shafer

  224
  Citations

• Voltage-dependent Anion Channel-1 (VDAC-1) Contributes to ATP Release and Cell Volume Regulation in Murine Cells

  Seiko F. Okada;Wanda K. O'Neal;Pingbo Huang;Robert A. Nicholas

  205
  Citations

• Genetics of chromosomally mediated intermediate resistance to ceftriaxone and cefixime in Neisseria gonorrhoeae.

  Shuqing Zhao;Margaret Duncan;Joshua Tomberg;Christopher Davies

  204
  Citations

• Identification and Analysis of Amino Acid Mutations in Porin IB That Mediate Intermediate-Level Resistance to Penicillin and Tetracycline in Neisseria gonorrhoeae

  Melanie Olesky;Marcia Hobbs;Robert A. Nicholas

  193
  Citations

• HEK293 human embryonic kidney cells endogenously express the P2Y1 and P2Y2 receptors.

  Joel B. Schachter;Susan M. Sromek;Robert A. Nicholas;T.Kendall Harden

  185
  Citations

• Porin-Mediated Antibiotic Resistance in Neisseria gonorrhoeae: Ion, Solute, and Antibiotic Permeation through PIB Proteins with penB Mutations

  Melanie Olesky;Shuqing Zhao;Robert L. Rosenberg;Robert A. Nicholas

  181
  Citations

• The Role of Amino Acids in Extracellular Loops of the Human P2Y1 Receptor in Surface Expression and Activation Processes

  Carsten Hoffmann;Stefano Moro;Robert A. Nicholas;T. Kendall Harden

  175
  Citations

• Extracellular NAD+ is an agonist of the human P2Y11 purinergic receptor in human granulocytes.

  Iliana Moreschi;Santina Bruzzone;Robert A. Nicholas;Floriana Fruscione

  166
  Citations

• Molecular and structural analysis of mosaic variants of penicillin-binding protein 2 conferring decreased susceptibility to expanded-spectrum cephalosporins in Neisseria gonorrhoeae: Role of epistatic mutations

  Joshua Tomberg;Magnus Unemo;Christopher Davies;Robert A Nicholas

  165
  Citations

• ATP, an agonist at the rat P2Y(4) receptor, is an antagonist at the human P2Y(4) receptor.

  C Kennedy;A D Qi;C L Herold;T K Harden

  161
  Citations