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H. Th. Marc Timmers

H. Th. Marc Timmers

D-Index & Metrics

Molecular Biology

D-Index
51
Citations
8985
World Ranking
2506
National Ranking
168

Overview

H. Th. Marc Timmers is affiliated with the University of Freiburg in Germany and specializes in biochemistry, genetics, and molecular biology. Their research focuses primarily on molecular biology, encompassing fields such as oncology, epidemiology, genetics, and surgery. The scientist's work is also concentrated on topics related to genomics and chromatin dynamics, epigenetics and DNA methylation, RNA modifications and cancer, as well as mechanisms of RNA and protein synthesis. Additional research areas include protein degradation and inhibitors, CRISPR and genetic engineering, and RNA research and splicing.

Throughout their career, Timmers has published extensively in various scientific journals. Frequent venues for their publications include bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Nucleic Acids Research, Blood, and Nature Structural & Molecular Biology.

Recent papers authored or co-authored by Timmers demonstrate a focus on transcription factors and gene regulatory mechanisms. Notable publications include:

  • SAGA and TFIID: Friends of TBP drifting apart, 2020, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
  • Hierarchical TAF1-dependent co-translational assembly of the basal transcription factor TFIID, 2023, Nature Structural & Molecular Biology
  • Evolutionary conservation of the fidelity of transcription, 2023, Nature Communications
  • Integrating quantitative proteomics with accurate genome profiling of transcription factors by greenCUT&RUN, 2021, Nucleic Acids Research
  • greenCUT&RUN: Efficient Genomic Profiling of GFP-Tagged Transcription Factors and Chromatin Regulators, 2021, Current Protocols

Timmers has collaborated regularly with a number of researchers, including:

  • Sheikh Nizamuddin
  • Martin L. Biniossek
  • Ezgi Ozyerli-Goknar
  • Stefanie Koidl
  • Oliver Schilling

Best Publications

  • Selective Anchoring of TFIID to Nucleosomes by Trimethylation of Histone H3 Lysine 4

    Michiel Vermeulen;Klaas W. Mulder;Sergei Denissov;W.W.M.Pim Pijnappel

  • Opening of an RNA polymerase II promoter occurs in two distinct steps and requires the basal transcription factors IIE and IIH.

    F. C. P. Holstege;P. C. Van Der Vliet;H. T. M. Timmers

  • Three transitions in the RNA polymerase II transcription complex during initiation

    Frank C. P. Holstege;Ulrike Fiedler;H. Th. Marc Timmers

  • Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin

    Heike Sandler;Jochen Kreth;H. Th. Marc Timmers;Georg Stoecklin

  • Identification of a ubiquitin-protein ligase subunit within the CCR4-NOT transcription repressor complex

    Thomas K. Albert;Hiroyuki Hanzawa;Yvonne I.A. Legtenberg;Marjolein J. de Ruwe

  • Menin Links Estrogen Receptor Activation to Histone H3K4 Trimethylation

    Koen M.A. Dreijerink;Klaas W. Mulder;G. Sebastiaan Winkler;Jo W.M. Höppener

  • TFIIH with inactive XPD helicase functions in transcription initiation but is defective in DNA repair

    G. Sebastiaan Winkler;Sofia J. Araújo;Ulrike Fiedler;Wim Vermeulen

  • ATAC-king the complexity of SAGA during evolution

    Gianpiero Spedale;H.Th. Marc Timmers;W.W.M. Pim Pijnappel

  • Human Ccr4-Not complexes contain variable deadenylase subunits.

    Nga-Chi Lau;Annemieke Kolkman;Frederik M. A. van Schaik;Klaas W. Mulder

  • A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system.

    Sjoerd J L van Wijk;Sjoerd J de Vries;Patrick Kemmeren;Anding Huang

  • Isolation and characterization of human orthologs of yeast CCR4–NOT complex subunits

    Thomas K. Albert;Marc Lemaire;Nynke L. van Berkum;Reiner Gentz

  • Promoter specificity of basal transcription factors

    Jeffrey D. Parvin;H.Th.Marc Timmers;Phillip A. Sharp

  • Novel critical role of a human Mediator complex for basal RNA polymerase II transcription

    Gerhard Mittler;Elisabeth Kremmer;H Th. Marc Timmers;Michael Meisterernst

  • Structural Model of the UbcH5B/CNOT4 Complex Revealed by Combining NMR, Mutagenesis, and Docking Approaches

    Cyril Dominguez;Alexandre M.J.J Bonvin;G.Sebastiaan Winkler;Frederik M.A van Schaik

  • Structural insight into the recognition of the H3K4me3 mark by the TFIID subunit TAF3.

    Hugo van Ingen;Frederik M.A. van Schaik;Hans Wienk;Joost Ballering

  • Balancing of histone H3K4 methylation states by the Kdm5c/SMCX histone demethylase modulates promoter and enhancer function.

    Nikolay S Outchkourov;Jose M Muiño;Kerstin Kaufmann;Wilfred F J van Ijcken

  • The Eukaryotic Ccr4-Not Complex: A Regulatory Platform Integrating mRNA Metabolism with Cellular Signaling Pathways?

    Martine A Collart;H Th Marc Timmers

  • Benchmarking stable isotope labeling based quantitative proteomics.

    A.F. Maarten Altelaar;Christian K. Frese;Christian Preisinger;Marco L. Hennrich

  • PHF8 Targets Histone Methylation and RNA Polymerase II To Activate Transcription

    Klaus Fortschegger;Petra de Graaf;Nikolay S. Outchkourov;Frederik M. A. van Schaik

  • Human Ccr4‐Not complex is a ligand‐dependent repressor of nuclear receptor‐mediated transcription

    G Sebastiaan Winkler;Klaas W Mulder;Vivian J Bardwell;Eric Kalkhoven

Frequent Co-Authors

Rolf Boelens
Rolf Boelens Utrecht University
Laszlo Tora
Laszlo Tora Institute of Genetics and Molecular and Cellular Biology
Frank C. P. Holstege
Frank C. P. Holstege Utrecht University
Martine A. Collart
Martine A. Collart University of Geneva
Alexandre M. J. J. Bonvin
Alexandre M. J. J. Bonvin Utrecht University
Michiel Vermeulen
Michiel Vermeulen Radboud University
Olaf M. Dekkers
Olaf M. Dekkers Leiden University Medical Center
Thomas Reinheckel
Thomas Reinheckel University of Freiburg
Manuel Irimia
Manuel Irimia Pompeu Fabra University
Shabaz Mohammed
Shabaz Mohammed University of Oxford

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