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Thomas Reinheckel

Thomas Reinheckel

D-Index & Metrics

Biology and Biochemistry

D-Index
73
Citations
21421
World Ranking
5882
National Ranking
419

Overview

Thomas Reinheckel is affiliated with the University of Freiburg in Germany. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a strong focus on Molecular Biology, Oncology, Epidemiology, Cell Biology, and Immunology as subfields of study.

Their work covers a range of main topics including:

  • Peptidase Inhibition and Analysis
  • Protease and Inhibitor Mechanisms
  • Advanced NMR Techniques and Applications
  • Inflammasome and immune disorders
  • Cellular transport and secretion
  • Atomic and Subatomic Physics Research
  • Alzheimer's disease research and treatments

Recent papers authored or co-authored by Reinheckel include:

  • Cathepsin B Gene Knockout Improves Behavioral Deficits and Reduces Pathology in Models of Neurologic Disorders, 2022, Pharmacological Reviews
  • Spatially and Temporally Defined Lysosomal Leakage Facilitates Mitotic Chromosome Segregation, 2020, Nature Communications
  • In Vivo Metabolic Imaging of [1- 13C]Pyruvate-d 3 Hyperpolarized By Reversible Exchange With Parahydrogen, 2023, Angewandte Chemie International Edition
  • Lysosomal Damage Drives Mitochondrial Proteome Remodelling and Reprograms Macrophage Immunometabolism, 2022, Nature Communications
  • Cathepsin D Deficiency in Mammary Epithelium Transiently Stalls Breast Cancer by Interference with mTORC1 Signaling, 2020, Nature Communications

Frequent co-authors collaborating with Reinheckel include:

  • Philipp Groß
  • Lisa Heß
  • Eduard Y. Chekmenev
  • Andreas B. Schmidt
  • Henri de Maissin

Common venues for publication consist of:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Theranostics
  • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  • Analysis & Sensing

Best Publications

  • The NALP3 inflammasome is involved in the innate immune response to amyloid-beta.

    Annett Halle;Veit Hornung;Gabor C Petzold;Cameron R Stewart

  • Degradation of oxidized proteins in mammalian cells.

    Tilman Grune;Thomas Reinheckel;Kelvin J. A. Davies

  • Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis

    Walter Halangk;Markus M. Lerch;Barbara Brandt-Nedelev;Wera Roth

  • Specialized roles for cysteine cathepsins in health and disease

    Jochen Reiser;Brian Adair;Thomas Reinheckel

  • Distinct roles for cysteine cathepsin genes in multistage tumorigenesis

    Vasilena Gocheva;Wei Zeng;Danxia Ke;David Klimstra

  • Intracellular Complement Activation Sustains T Cell Homeostasis and Mediates Effector Differentiation

    M. Kathryn Liszewski;Martin Kolev;Gaelle Le Friec;Marilyn Leung

  • Emerging roles of cysteine cathepsins in disease and their potential as drug targets.

    Olga Vasiljeva;Thomas Reinheckel;Christoph Peters;Dusan Turk

  • Comparative resistance of the 20S and 26S proteasome to oxidative stress.

    Thomas Reinheckel;Nicolle Sitte;Oliver Ullrich;Ulrike Kuckelkorn

  • Proteolysis in cultured liver epithelial cells during oxidative stress. Role of the multicatalytic proteinase complex, proteasome.

    Tilman Grune;Thomas Reinheckel;Minakshi Joshi;Kelvin J.A. Davies

  • Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment

    Georgy Mikhaylov;Ursa Mikac;Anna A. Magaeva;Volya I. Itin

  • Tumor Cell–Derived and Macrophage-Derived Cathepsin B Promotes Progression and Lung Metastasis of Mammary Cancer

    Olga Vasiljeva;Anna Papazoglou;Achim Krüger;Harald Brodoefel

  • Cathepsin L is required for endothelial progenitor cell-induced neovascularization.

    Carmen Urbich;Christopher Heeschen;Alexandra Aicher;Ken-ichiro Sasaki

  • Degradation of Oxidized Proteins in K562 Human Hematopoietic Cells by Proteasome

    Tilman Grune;Thomas Reinheckel;Kelvin J.A. Davies;Kelvin J.A. Davies

  • Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation

    Sébastien Conus;Remo Perozzo;Thomas Reinheckel;Christoph Peters

  • Thyroid functions of mouse cathepsins B, K, and L

    Bianca Friedrichs;Carmen Tepel;Thomas Reinheckel;Jan Deussing

  • Poly-ADP ribose polymerase activates nuclear proteasome to degrade oxidatively damaged histones

    Oliver Ullrich;Thomas Reinheckel;Nicolle Sitte;Ralf Hass

  • Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter

    Sukkid Yasothornsrikul;Doron Greenbaum;Katalin F. Medzihradszky;Thomas Toneff

  • Towards specific functions of lysosomal cysteine peptidases: phenotypes of mice deficient for cathepsin B or cathepsin L.

    Thomas Reinheckel;Jan Deussing;Wera Roth;Christoph Peters

  • Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L.

    Jörg Stypmann;Kerstin Gläser;Wera Roth;Desmond J. Tobin

  • Differential impairment of 20S and 26S proteasome activities in human hematopoietic K562 cells during oxidative stress.

    Thomas Reinheckel;Oliver Ullrich;Nicolle Sitte;Tilman Grune

Frequent Co-Authors

Christoph Peters
Christoph Peters University of Freiburg
Tilman Grune
Tilman Grune University of Potsdam
Vivian Hook
Vivian Hook University of California, San Diego
Oliver Schilling
Oliver Schilling University of Freiburg
Paul Saftig
Paul Saftig Kiel University
Boris Turk
Boris Turk Jožef Stefan Institute
Melanie Boerries
Melanie Boerries University of Freiburg
Jan M. Deussing
Jan M. Deussing Max Planck Society
Kelvin J.A. Davies
Kelvin J.A. Davies University of Southern California
Markus M. Lerch
Markus M. Lerch Greifswald University Hospital

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