D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 117 Citations 70,106 297 World Ranking 312 National Ranking 26

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Internal medicine

His primary areas of investigation include Cell biology, Molecular biology, Biochemistry, Autophagy and ADAM10. His Cell biology study combines topics in areas such as Amyloid precursor protein secretase, Lysosome, Sheddase and Ectodomain. Paul Saftig has researched Amyloid precursor protein secretase in several fields, including Gamma secretase, APH-1 and Notch signaling pathway.

As a part of the same scientific family, he mostly works in the field of Biochemistry, focusing on Amyloid precursor protein and, on occasion, Presenilin, Cleavage, Neurogenesis and Neuroscience. His studies deal with areas such as Membrane protein, Programmed cell death and Heat shock protein as well as Autophagy. His work deals with themes such as Chemokine, ADAM17 Protein and ADAM Proteins, which intersect with ADAM10.

His most cited work include:

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (4170 citations)
  • Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. (2103 citations)
  • A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. (1850 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of study are Cell biology, Biochemistry, ADAM10, Molecular biology and Internal medicine. His research investigates the connection with Cell biology and areas like Autophagy which intersect with concerns in Vacuole and Programmed cell death. He works mostly in the field of Biochemistry, limiting it down to concerns involving Amyloid precursor protein secretase and, occasionally, APH-1 and Gamma secretase.

Paul Saftig focuses mostly in the field of ADAM10, narrowing it down to matters related to Amyloid precursor protein and, in some cases, Neuroscience. Paul Saftig combines subjects such as Receptor and Cathepsin D with his study of Molecular biology. Within one scientific family, he focuses on topics pertaining to Endocrinology under Internal medicine, and may sometimes address concerns connected to Cathepsin K.

He most often published in these fields:

  • Cell biology (53.89%)
  • Biochemistry (23.06%)
  • ADAM10 (16.58%)

What were the highlights of his more recent work (between 2014-2021)?

  • Cell biology (53.89%)
  • ADAM10 (16.58%)
  • Autophagy (11.14%)

In recent papers he was focusing on the following fields of study:

His main research concerns Cell biology, ADAM10, Autophagy, Lysosome and Transmembrane protein. His research integrates issues of Endocytic cycle, Biochemistry, Tetraspanin and Membrane protein in his study of Cell biology. His ADAM10 study incorporates themes from Proteases, Ectodomain, Synapse and Amyloid precursor protein.

The Autophagy study combines topics in areas such as Endocrinology and Programmed cell death. His Programmed cell death study integrates concerns from other disciplines, such as Computational biology and Autolysosome. His Transmembrane protein research incorporates themes from Lamellar granule, Intramembrane protease, Transmembrane domain and Cytosol.

Between 2014 and 2021, his most popular works were:

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (4170 citations)
  • The alpha secretase ADAM10: A metalloprotease with multiple functions in the brain. (116 citations)
  • Repetitive stimulation of autophagy-lysosome machinery by intermittent fasting preconditions the myocardium to ischemia-reperfusion injury. (97 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Internal medicine

Paul Saftig mainly investigates Cell biology, ADAM10, Autophagy, Lysosome and Biochemistry. His biological study spans a wide range of topics, including Receptor, Lipid bilayer fusion and Alpha-synuclein. He interconnects Proteases, Neurodegeneration and Amyloid precursor protein secretase, Amyloid precursor protein in the investigation of issues within ADAM10.

His Autophagy study combines topics from a wide range of disciplines, such as Lysosomal storage disease and Programmed cell death. His research in Lysosome intersects with topics in Endocytic cycle and Internal medicine, Intermittent fasting, Endocrinology. His Recombinant DNA, Immunoprecipitation, Mutant and Glucocerebrosidase study, which is part of a larger body of work in Biochemistry, is frequently linked to Lysosomal transport, bridging the gap between disciplines.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif.
Autophagy (2021)

7847 Citations

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin.
Autophagy (2016)

6803 Citations

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin.
Autophagy (2016)

4781 Citations

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.

Bart De Strooper;Wim Annaert;Philippe Cupers;Paul Saftig.
Nature (1999)

2509 Citations

Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy.

Lionel Apetoh;François Ghiringhelli;Antoine Tesniere;Antoine Tesniere;Antoine Tesniere;Michel Obeid;Michel Obeid;Michel Obeid.
Nature Medicine (2007)

2446 Citations

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

Bart De Strooper;Paul Saftig;Paul Saftig;Katleen Craessaerts;Hugo Vanderstichele.
Nature (1998)

2225 Citations

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

Paul Saftig;Judith Klumperman.
Nature Reviews Molecular Cell Biology (2009)

1324 Citations

Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands

Umut Sahin;Gisela Weskamp;Kristine Kelly;Kristine Kelly;Hong-Ming Zhou.
Journal of Cell Biology (2004)

1074 Citations

Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice

Paul Saftig;Ernst Hunziker;Olaf Wehmeyer;Sheila Jones.
Proceedings of the National Academy of Sciences of the United States of America (1998)

1012 Citations

Role for Rab7 in maturation of late autophagic vacuoles

Stefanie Jäger;Cecilia Bucci;Isei Tanida;Takashi Ueno.
Journal of Cell Science (2004)

963 Citations

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