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Paul Saftig

Paul Saftig

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Biology and Biochemistry
Germany
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
133
Citations
87645
World Ranking
369
National Ranking
25

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2025 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2023 - Research.com Biology and Biochemistry in Germany Leader Award

Overview

Paul Saftig is affiliated with Kiel University in Germany and has contributed significantly to the fields of Medicine and Biochemistry, Genetics, and Molecular Biology. Their research primarily focuses on cellular and molecular mechanisms relevant to physiology and disease.

The scientist's main areas of study cover several subfields, including:

  • Molecular Biology
  • Physiology
  • Cell Biology
  • Epidemiology
  • Immunology and Allergy

Their research topics emphasize:

  • Cellular transport and secretion
  • Lysosomal Storage Disorders Research
  • Alzheimer's disease research and treatments
  • Cell Adhesion Molecules Research
  • Calcium signaling and nucleotide metabolism
  • Autophagy in Disease and Therapy
  • Lipid Membrane Structure and Behavior

Paul Saftig has published in various scientific venues, with frequent appearances in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Proceedings of the National Academy of Sciences
  • Journal of Cell Science
  • Cell Reports

Recent papers authored or co-authored by Paul Saftig include:

  • "How Lysosomes Sense, Integrate, and Cope with Stress", 2020, Trends in Biochemical Sciences
  • "Cholesterol Handling in Lysosomes and Beyond", 2020, Trends in Cell Biology
  • "Systemic AAV9.LAMP2B injection reverses metabolic and physiologic multiorgan dysfunction in a murine model of Danon disease", 2020, Science Translational Medicine
  • "The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons", 2020, Cell Reports
  • "Cathepsin D regulates cerebral Aβ42/40 ratios via differential degradation of Aβ42 and Aβ40", 2020, Alzheimer's Research & Therapy

Frequent co-authors in their work include:

  • Markus Daμμe
  • Saskia Heybrock
  • Alessandro Di Spiezio
  • Lisa Gallwitz
  • Michaela Schweizer

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy.

    Lionel Apetoh;François Ghiringhelli;Antoine Tesniere;Antoine Tesniere;Antoine Tesniere;Michel Obeid;Michel Obeid;Michel Obeid

  • A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.

    Bart De Strooper;Wim Annaert;Philippe Cupers;Paul Saftig

  • Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

    Bart De Strooper;Paul Saftig;Paul Saftig;Katleen Craessaerts;Hugo Vanderstichele

  • Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

    Paul Saftig;Judith Klumperman

  • Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands

    Umut Sahin;Gisela Weskamp;Kristine Kelly;Kristine Kelly;Hong-Ming Zhou

  • Role for Rab7 in maturation of late autophagic vacuoles

    Stefanie Jäger;Cecilia Bucci;Isei Tanida;Takashi Ueno

  • Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice

    Yoshitaka Tanaka;Yoshitaka Tanaka;Gundula Guhde;Anke Suter;Eeva Liisa Eskelinen;Eeva Liisa Eskelinen;Eeva Liisa Eskelinen

  • Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice

    Paul Saftig;Ernst Hunziker;Olaf Wehmeyer;Sheila Jones

  • The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis.

    Guillaume van Niel;Guillaume van Niel;Stéphanie Charrin;Sabrina Simoes;Sabrina Simoes;Maryse Romao;Maryse Romao

  • Control of peripheral nerve myelination by the beta-secretase BACE1.

    Michael Willem;Alistair N. Garratt;Bozidar Novak;Martin Citron

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Autophagy: a lysosomal degradation pathway with a central role in health and disease.

    Eeva-Liisa Eskelinen;Paul Saftig

  • The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts.

    Dieter Hartmann;Bart De Strooper;Lutgarde Serneels;Kathleen Craessaerts

  • ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation.

    Thorsten Maretzky;Karina Reiss;Andreas Ludwig;Julian Buchholz

  • The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion.

    Christian Hundhausen;Dominika Misztela;Theo A. Berkhout;Neil Broadway

  • At the acidic edge: emerging functions for lysosomal membrane proteins.

    Eeva Liisa Eskelinen;Yoshitaka Tanaka;Paul Saftig

  • LAMP proteins are required for fusion of lysosomes with phagosomes.

    Kassidy K Huynh;Eeva-Liisa Eskelinen;Cameron C Scott;Anatoly Malevanets

  • Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

    An Herreman;Dieter Hartmann;Wim Annaert;Paul Saftig

Frequent Co-Authors

Dieter Hartmann
Dieter Hartmann University of Bonn
Eeva-Liisa Eskelinen
Eeva-Liisa Eskelinen University of Turku
Christoph Peters
Christoph Peters University of Freiburg
Carl P. Blobel
Carl P. Blobel Cornell University
Kurt von Figura
Kurt von Figura University of Göttingen
Andreas Ludwig
Andreas Ludwig RWTH Aachen University
Rudi D'Hooge
Rudi D'Hooge KU Leuven
Wim Annaert
Wim Annaert KU Leuven
Markus Glatzel
Markus Glatzel Universität Hamburg

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