Kurt von Figura

Overview

Best Publications

• Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

  Bart De Strooper;Paul Saftig;Paul Saftig;Katleen Craessaerts;Hugo Vanderstichele

  2450
  Citations

• Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice

  Yoshitaka Tanaka;Yoshitaka Tanaka;Gundula Guhde;Anke Suter;Eeva Liisa Eskelinen;Eeva Liisa Eskelinen;Eeva Liisa Eskelinen

  1089
  Citations

• The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts.

  Dieter Hartmann;Bart De Strooper;Lutgarde Serneels;Kathleen Craessaerts

  868
  Citations

• μ1A‐adaptin‐deficient mice: lethality, loss of AP‐1 binding and rerouting of mannose 6‐phosphate receptors

  Christoph Meyer;Daniela Zizioli;Susanne Lausmann;Eeva-Liisa Eskelinen

  524
  Citations

• Complementation cloning identifies CDG-IIc, a new type of congenital disorders of glycosylation, as a GDP-fucose transporter deficiency.

  Torben Lübke;Thorsten Marquardt;Amos Etzioni;Enno Hartmann

  484
  Citations

• Role of LAMP-2 in Lysosome Biogenesis and Autophagy

  Eeva Liisa Eskelinen;Anna Lena Illert;Yoshitaka Tanaka;Günter Schwarzmann

  453
  Citations

• Cathepsin D Deficiency Induces Lysosomal Storage with Ceroid Lipofuscin in Mouse CNS Neurons

  Masato Koike;Hiroshi Nakanishi;Paul Saftig;Junji Ezaki

  452
  Citations

• Multiple Sulfatase Deficiency Is Caused by Mutations in the Gene Encoding the Human Cα-Formylglycine Generating Enzyme

  Thomas Dierks;Bernhard Schmidt;Ljudmila V. Borissenko;Jianhe Peng

  430
  Citations

• A di-leucine-based motif in the cytoplasmic tail of LIMP-II and tyrosinase mediates selective binding of AP-3

  S Höning;I V Sandoval;K von Figura

  426
  Citations

• Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling

  Wera Roth;Wera Roth;Jan Deussing;Vladimir A. Botchkarev;Meike Pauly-Evers;Meike Pauly-Evers

  414
  Citations

• Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease).

  Masato Koike;Masahiro Shibata;Satoshi Waguri;Kentaro Yoshimura

  393
  Citations

• Crystal structure of human arylsulfatase A: the aldehyde function and the metal ion at the active site suggest a novel mechanism for sulfate ester hydrolysis.

  G Lukatela;N Krauss;K Theis;T Selmer

  390
  Citations

• Phosphorylation of the AP2 μ subunit by AAK1 mediates high affinity binding to membrane protein sorting signals

  Doris Ricotta;Sean D. Conner;Sandra L. Schmid;Kurt Von Figura

  361
  Citations

• Molecular Basis of Different Forms of Metachromatic Leukodystrophy

  A Polten;A L Fluharty;C B Fluharty;J Kappler

  356
  Citations

• Disturbed Cholesterol Traffic but Normal Proteolytic Function in LAMP-1/LAMP-2 Double-deficient Fibroblasts

  Eeva Liisa Eskelinen;Christine Katrin Schmidt;Silja Neu;Marion Willenborg

  309
  Citations

• Thyroid functions of mouse cathepsins B, K, and L

  Bianca Friedrichs;Carmen Tepel;Thomas Reinheckel;Jan Deussing

  293
  Citations

• The Two Mannose 6-Phosphate Receptors Transport Distinct Complements of Lysosomal Proteins

  Regina Pohlmann;Martin Wendland Christian Boeker;Kurt von Figura

  273
  Citations

• Normal Lysosomal Morphology and Function in LAMP-1-deficient Mice

  Nicole Andrejewski;Eeva Liisa Punnonen;Gundula Guhde;Yoshitaka Tanaka

  254
  Citations

• Sequence determinants directing conversion of cysteine to formylglycine in eukaryotic sulfatases

  Thomas Dierks;M.Rita Lecca;Petra Schlotterhose;Bernhard Schmidt

  230
  Citations

• Molecular basis for multiple sulfatase deficiency and mechanism for formylglycine generation of the human formylglycine-generating enzyme.

  Thomas Dierks;Achim Dickmanns;Andrea Preusser-Kunze;Bernhard Schmidt

  226
  Citations