Thomas Dierks

Best Publications

• Multiple Sulfatase Deficiency Is Caused by Mutations in the Gene Encoding the Human Cα-Formylglycine Generating Enzyme

  Thomas Dierks;Bernhard Schmidt;Ljudmila V. Borissenko;Jianhe Peng

  430
  Citations

• Sequence determinants directing conversion of cysteine to formylglycine in eukaryotic sulfatases

  Thomas Dierks;M.Rita Lecca;Petra Schlotterhose;Bernhard Schmidt

  230
  Citations

• Molecular basis for multiple sulfatase deficiency and mechanism for formylglycine generation of the human formylglycine-generating enzyme.

  Thomas Dierks;Achim Dickmanns;Andrea Preusser-Kunze;Bernhard Schmidt

  226
  Citations

• The heparanome - The enigma of encoding and decoding heparan sulfate sulfation

  William C. Lamanna;Ina Kalus;Michael Padva;Rebecca J. Baldwin

  221
  Citations

• Conversion of cysteine to formylglycine: A protein modification in the endoplasmic reticulum

  Thomas Dierks;Bernhard Schmidt;Kurt von Figura

  215
  Citations

• 1.3 Å structure of arylsulfatase from Pseudomonas aeruginosa establishes the catalytic mechanism of sulfate ester cleavage in the sulfatase family

  Imke Boltes;Honorata Czapinska;Antje Kahnert;Rixa von Bülow

  200
  Citations

• Sulf Loss Influences N-, 2-O-, and 6-O-Sulfation of Multiple Heparan Sulfate Proteoglycans and Modulates Fibroblast Growth Factor Signaling

  William Christopher Lamanna;Marc-André Frese;Martina Balleininger;Thomas Dierks

  196
  Citations

• The mitochondrial aspartate/glutamate and ADP/ATP carrier switch from obligate counterexchange to unidirectional transport after modification by SH-reagents.

  Thomas Dierks;Angelika Salentin;Claudia Heberger;Reinhard Krämer

  185
  Citations

• Posttranslational Formation of Formylglycine in Prokaryotic Sulfatases by Modification of Either Cysteine or Serine

  Thomas Dierks;Claudia Miech;Jörg Hummerjohann;Bernhard Schmidt

  162
  Citations

• Heparan sulfate 6-O-endosulfatases: discrete in vivo activities and functional co-operativity

  William C. Lamanna;Rebecca J. Baldwin;Michael Padva;Ina Kalus

  153
  Citations

• Heparan sulfate 6-O-endosulfatases: discrete in vivo activities and functional co-operativity.

  William C. Lamanna;William C. Lamanna;Rebecca J. Baldwin;Michael Padva;Ina Kalus

  153
  Citations

• Molecular basis of multiple sulfatase deficiency, mucolipidosis II/III and Niemann-Pick C1 disease — Lysosomal storage disorders caused by defects of non-lysosomal proteins☆

  Thomas Dierks;Lars Schlotawa;Marc-André Frese;Karthikeyan Radhakrishnan

  133
  Citations

• A novel protein modification generating an aldehyde group in sulfatases: its role in catalysis and disease

  Kurt von Figura;Bernhard Schmidt;Thorsten Selmer;Thomas Dierks

  128
  Citations

• A general binding mechanism for all human sulfatases by the formylglycine-generating enzyme

  Dirk Roeser;Andrea Preusser-Kunze;Bernhard Schmidt;Kathrin Gasow

  125
  Citations

• Arylsulfatase from Klebsiella pneumoniae carries a formylglycine generated from a serine.

  Claudia Miech;Thomas Dierks;Thorsten Selmer;Kurt von Figura

  122
  Citations

• Amino acid residues forming the active site of arylsulfatase A. Role in catalytic activity and substrate binding.

  Anne Waldow;Bernhard Schmidt;Thomas Dierks;Rixa von Bülow

  119
  Citations

• Crystal Structure of an Enzyme-Substrate Complex Provides Insight Into the Interaction between Human Arylsulfatase a and its Substrates During Catalysis

  R Von Bulow;B Schmidt;T Dierks;K Von Figura

  118
  Citations

• The iron sulfur protein AtsB is required for posttranslational formation of formylglycine in the Klebsiella sulfatase.

  Claudia Szameit;Claudia Miech;Martina Balleininger;Bernhard Schmidt

  117
  Citations

• Crystal Structure of the Alkylsulfatase Atsk: Insights Into the Catalytic Mechanism of the Fe(II) Alpha-Ketoglutarate-Dependent Dioxygenase Superfamily

  Ilka Müller;Antje Kahnert;Thomas Pape;George M. Sheldrick

  114
  Citations

• SULFATASES, TRAPPING OF THE SULFATED ENZYME INTERMEDIATE BY SUBSTITUTING THE ACTIVE SITE FORMYLGLYCINE

  M Recksiek;T Selmer;T Dierks;B Schmidt

  111
  Citations