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Volkmar Gieselmann

Volkmar Gieselmann

D-Index & Metrics

Molecular Biology

D-Index
64
Citations
12424
World Ranking
1760
National Ranking
123

Overview

Volkmar Gieselmann is affiliated with the University of Bonn in Germany. Their research focuses on various aspects of biochemistry, genetics, molecular biology, and medicine, with a significant emphasis on lysosomal storage disorders and cellular transport mechanisms.

The scientist has contributed extensively to several subfields, including cell biology, physiology, molecular biology, epidemiology, and organic chemistry. Their publications often explore intricate cellular processes and biochemical pathways relevant to disease mechanisms and potential therapeutic approaches.

Among the main topics addressed in their work are:

  • Lysosomal Storage Disorders Research
  • Cellular transport and secretion
  • Trypanosoma species research and implications
  • Ubiquitin and proteasome pathways
  • Carbohydrate Chemistry and Synthesis
  • Neurogenesis and neuroplasticity mechanisms
  • Caveolin-1 and cellular processes

Recent notable publications by Volkmar Gieselmann include:

  • Metachromatic leukodystrophy and transplantation: remyelination, no cross-correction (2020, Annals of Clinical and Translational Neurology)
  • Cross-linking of the endolysosomal system reveals potential flotillin structures and cargo (2022, Nature Communications)
  • Extremely low arylsulfatase A enzyme activity does not necessarily cause symptoms: A long-term follow-up and review of the literature (2022, JIMD Reports)
  • Brain cell type-specific endocytosis of arylsulfatase A identifies limitations of enzyme-based therapies for metachromatic leukodystrophy (2020, Human Molecular Genetics)
  • Proteaphagy in Mammalian Cells Can Function Independent of ATG5/ATG7 (2020, Molecular & Cellular Proteomics)

The distribution of their work across publication venues shows a consistent contribution to journals focused on molecular genetics and clinical neurology, as well as preprint platforms. Frequent publication venues include bioRxiv (Cold Spring Harbor Laboratory), Human Molecular Genetics, Annals of Clinical and Translational Neurology, Nature Communications, and JIMD Reports.

Volkmar Gieselmann has worked collaboratively with several researchers in the field. Frequent co-authors include:

  • Dominic Winter
  • Ulrich Matzner
  • Martin Eisenacher
  • Marc Sylvester
  • Jasjot Singh

Their body of work collectively advances understanding in cellular and molecular mechanisms underlying several inherited metabolic conditions and cellular homeostasis processes, particularly regarding enzyme activity and intracellular trafficking pathways. The research contributes to elucidating both fundamental biological processes and their implications for disease treatment strategies.

Best Publications

  • Lysosomal disorders: from storage to cellular damage.

    Andrea Ballabio;Volkmar Gieselmann

  • Crystal structure of human arylsulfatase A: the aldehyde function and the metal ion at the active site suggest a novel mechanism for sulfate ester hydrolysis.

    G Lukatela;N Krauss;K Theis;T Selmer

  • Molecular Basis of Different Forms of Metachromatic Leukodystrophy

    A Polten;A L Fluharty;C B Fluharty;J Kappler

  • Adult ceramide synthase 2 (CerS2) deficient mice exhibit myelin sheath defects, cerebellar degeneration and hepatocarcinomas

    Silke Imgrund;Dieter Hartmann;Hany Farwanah;Matthias Eckhardt

  • Arylsulfatase A pseudodeficiency: loss of a polyadenylylation signal and N-glycosylation site

    V Gieselmann;A Polten;J Kreysing;K von Figura

  • Biosynthesis and transport of cathepsin D in cultured human fibroblasts.

    V Gieselmann;R Pohlmann;A Hasilik;K Von Figura

  • Phenotype of arylsulfatase A-deficient mice: Relationship to human metachromatic leukodystrophy

    Barbara Hess;Paul Saftig;Dieter Hartmann;Ruth Coenen

  • Enzyme replacement improves nervous system pathology and function in a mouse model for metachromatic leukodystrophy

    Ulrich Matzner;Eva Herbst;Kerstin Khalaj Hedayati;Renate Lüllmann-Rauch

  • Cloning and expression of human arylsulfatase A.

    C. Stein;V. Gieselmann;J. Kreysing;B. Schmidt

  • Absence of 2-Hydroxylated Sphingolipids Is Compatible with Normal Neural Development But Causes Late-Onset Axon and Myelin Sheath Degeneration

    Inge Zöller;Marion Meixner;Dieter Hartmann;Heinrich Büssow

  • Metachromatic leukodystrophy--an update.

    V. Gieselmann;I. Krägeloh-Mann

  • Mutation of FA2H underlies a complicated form of hereditary spastic paraplegia (SPG35).

    Katherine J. Dick;Matthias Eckhardt;Coro Paisán-Ruiz;Aisha Alkhayat Alshehhi

  • Lysosomal storage diseases

    Volkmar Gieselmann

  • Processing of human cathepsin D in lysosomes in vitro.

    V Gieselmann;A Hasilik;K von Figura

  • A mammalian fatty acid hydroxylase responsible for the formation of α-hydroxylated galactosylceramide in myelin

    Matthias Eckhardt;Afshin Yaghootfam;Simon N. Fewou;Inge Zöller

  • Collapsin response mediator protein-4 regulates F-actin bundling.

    Volker Rosslenbroich;Lingsong Dai;Stephan L. Baader;Angelika A. Noegel

  • Molecular genetics of metachromatic leukodystrophy

    V Gieselmann;J Zlotogora;A Harris;D A Wenger

  • Primary cultures of rat hepatocytes synthesize fibronectin

    Bruno Voss;Salah Allam;Jürgen Rauterberg;Kurt Ullrich

  • Intracerebral adeno-associated virus-mediated gene transfer in rapidly progressive forms of metachromatic leukodystrophy

    Caroline Sevin;Abdellatif Benraiss;Debby Van Dam;Delphine Bonnin

  • The family of hepatoma-derived growth factor proteins: characterization of a new member HRP-4 and classification of its subfamilies

    Frank Dietz;Sebastian Franken;Kenya Yoshida;Hideji Nakamura

Frequent Co-Authors

Dieter Hartmann
Dieter Hartmann University of Bonn
Rudi D'Hooge
Rudi D'Hooge KU Leuven
Andrej Hasilik
Andrej Hasilik Philipp University of Marburg
Thomas Braulke
Thomas Braulke University Medical Center Hamburg-Eppendorf
Jan-Eric Månsson
Jan-Eric Månsson University of Gothenburg
Peter Paul De Deyn
Peter Paul De Deyn University of Antwerp
David A. Wenger
David A. Wenger Thomas Jefferson University
Kurt von Figura
Kurt von Figura University of Göttingen
Christoph Peters
Christoph Peters University of Freiburg
Michael T. Heneka
Michael T. Heneka University Hospital Bonn

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