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Molecular Biology

D-Index
69
Citations
16108
World Ranking
1477
National Ranking
748

Overview

Ralf Janknecht is affiliated with the University of Oklahoma Health Sciences Center in the United States. Their research contributions primarily span the fields of Biochemistry, Genetics, and Molecular Biology, with additional work in Medicine. Within these domains, key subfields include Molecular Biology, Pulmonary and Respiratory Medicine, Epidemiology, Pathology and Forensic Medicine, and Pharmacology.

Janknecht's research topics cover a variety of areas related to gene regulation and cancer biology. Major topics include:

  • Epigenetics and DNA Methylation
  • Cancer-related gene regulation
  • Histone Deacetylase Inhibitors Research
  • Prostate Cancer Treatment and Research
  • Liver Disease Diagnosis and Treatment
  • Mitochondrial Function and Pathology
  • Kruppel-like factors research

Their publication record consists of multiple peer-reviewed papers, often collaborating with frequent coauthors such as Sangphil Oh, Ruicai Gu, Willard M. Freeman, Sook Shin, and Yuan Sui. Janknecht has published extensively in journals including Molecular Cancer Research, Frontiers in Oncology, and Scientific Reports.

Notable recent publications include:

  • "Crucial Functions of the JMJD1/KDM3 Epigenetic Regulators in Cancer," 2020, Molecular Cancer Research
  • "Promotion of colorectal cancer by transcription factor BHLHE40 involves upregulation of ADAM19 and KLF7," 2023, Frontiers in Oncology
  • "Opposite Roles of the JMJD1A Interaction Partners MDFI and MDFIC in Colorectal Cancer," 2020, Scientific Reports
  • "Absence of Either Ripk3 or Mlkl Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis," 2023, Molecular Cancer Research
  • "Cooperation between ETS transcription factor ETV1 and histone demethylase JMJD1A in colorectal cancer," 2020, International Journal of Oncology

Their frequent publication venues reflect an ongoing focus on cancer biology and molecular regulation mechanisms, with journals such as:

  • Molecular Cancer Research
  • Frontiers in Oncology
  • Scientific Reports
  • Trends in Biochemical Sciences
  • JCI Insight

Janknecht's collaborative efforts often involve researchers specializing in molecular oncology, epigenetics, and cancer therapeutics, contributing to a broader understanding of gene regulation in cancer progression. This includes studies on epigenetic regulators such as JMJD1/KDM3 and their roles in multiple cancer types including colorectal and liver cancer.

Best Publications

  • Activation of ternary complex factor Elk-1 by MAP kinases

    Ralf Janknecht;Wolfram H. Ernst;Vera Pingoud;Alfred Nordheim

  • Rapid and efficient purification of native histidine-tagged protein expressed by recombinant vaccinia virus.

    R Janknecht;G de Martynoff;J Lou;R A Hipskind

  • TGF-β-stimulated cooperation of Smad proteins with the coactivators CBP/p300

    Ralf Janknecht;Nicholas J. Wells;Tony Hunter

  • A growing coactivator network

    Ralf Janknecht;Tony Hunter

  • The Kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136

    Peter Blume-Jensen;Ralf Janknecht;Tony Hunter

  • KDM4/JMJD2 Histone Demethylases: Epigenetic Regulators in Cancer Cells

    William L. Berry;Ralf Janknecht

  • ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification.

    Dongjun Lee;Changwon Park;Ho Lee;Jesse J. Lugus

  • Transcriptional control: Versatile molecular glue

    Ralf Janknecht;Tony Hunter

  • Convergence of MAP kinase pathways on the ternary complex factor Sap-1a

    Ralf Janknecht;Tony Hunter

  • Independence of Repressive Histone Marks and Chromatin Compaction during Senescent Heterochromatic Layer Formation

    Tamir Chandra;Kristina Kirschner;Jean Yves Thuret;Benjamin D. Pope

  • CBP/p300 interact with and function as transcriptional coactivators of BRCA1

    Gerald M. Pao;Ralf Janknecht;Heinz Ruffner;Tony Hunter

  • ETV1, 4 and 5: An Oncogenic Subfamily of ETS Transcription Factors

    Sangphil Oh;Sook Shin;Ralf Janknecht

  • Interaction of the co-activator CBP with Myb proteins: effects on Myb-specific transactivation and on the cooperativity with NF-M

    Michael Oelgeschläger;Ralf Janknecht;Joachim Krieg;Sabine Schreek

  • Gene regulation by Ets proteins

    Ralf Janknecht;Alfred Nordheim

  • Signalling pathways: Jack of all cascades

    Michael A. Cahill;Ralf Janknecht;Alfred Nordheim

  • MAP Kinase-Dependent Transcriptional Coactivation by Elk-1 and Its Cofactor CBP☆

    Ralf Janknecht;Alfred Nordheim

  • Ras/Rap effector specificity determined by charge reversal

    Nicolas Nassar;Gudrun Horn;Christian Herrmann;Christoph Block

  • p38-2, a Novel Mitogen-activated Protein Kinase with Distinct Properties

    Bernd Stein;Maria X. Yang;David B. Young;Ralf Janknecht

  • Involvement of RNA helicases p68 and p72 in colon cancer.

    Sook Shin;Kari L. Rossow;Joseph P. Grande;Ralf Janknecht

  • Activation of androgen receptor by histone demethylases JMJD2A and JMJD2D.

    Sook Shin;Ralf Janknecht

Frequent Co-Authors

Tony Hunter
Tony Hunter Salk Institute for Biological Studies
Joseph P. Grande
Joseph P. Grande Mayo Clinic
John W. Kappler
John W. Kappler National Jewish Health
Sean C. Dowdy
Sean C. Dowdy Mayo Clinic
Alfred Nordheim
Alfred Nordheim University of Tübingen
Philippa Marrack
Philippa Marrack National Jewish Health
Hendrik G. Stunnenberg
Hendrik G. Stunnenberg Radboud University
Scott W. Lowe
Scott W. Lowe Memorial Sloan Kettering Cancer Center

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