2026 John W. Kappler: Immunology Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Immunology	147	131	123	87	81	533	84385

Research.com Recognitions

2026 - Research.com Immunology in United States Leader Award
2025 - Research.com Immunology in United States Leader Award
2020 - Distinguished Fellows of the American Association of Immunologists (AAI)
2008 - Member of the National Academy of Medicine (NAM)
1994 - Louisa Gross Horwitz Prize, Columbia University
1993 - Paul Ehrlich and Ludwig Darmstaedter Prize
1989 - Member of the National Academy of Sciences

Overview

John W. Kappler is affiliated with National Jewish Health in the United States. Their research spans multiple fields including Immunology and Microbiology, Medicine, and Biochemistry, Genetics and Molecular Biology, with a significant focus on subfields such as Immunology, Infectious Diseases, Molecular Biology, Genetics, and Radiology, Nuclear Medicine and Imaging.

Their main research topics include:

Immune Cell Function and Interaction
T-cell and B-cell Immunology
Diabetes and associated disorders
SARS-CoV-2 and COVID-19 Research
COVID-19 Clinical Research Studies
Immunotherapy and Immune Responses
Monoclonal and Polyclonal Antibodies Research

Frequently collaborating coauthors include Philippa Marrack, Pengcheng Wei, Haolin Liu, Gongyi Zhang, and Zhongzhou Chen.

John W. Kappler has contributed to a range of journals, with frequent publications in venues such as:

bioRxiv (Cold Spring Harbor Laboratory)
The Journal of Immunology
Proceedings of the National Academy of Sciences
Frontiers in Immunology
mAbs

Some recent research papers published by John W. Kappler include:

The basis of a more contagious 501Y.V1 variant of SARS-CoV-2, 2021, Cell Research
SARS-CoV-2 Variants of Concern and Variants of Interest Receptor Binding Domain Mutations and Virus Infectivity, 2022, Frontiers in Immunology
501Y.V2 and 501Y.V3 variants of SARS-CoV-2 lose binding to bamlanivimab in vitro, 2021, mAbs
Lysosomal cathepsin creates chimeric epitopes for diabetogenic CD4 T cells via transpeptidation, 2020, The Journal of Experimental Medicine
The Lambda variant of SARS-CoV-2 has a better chance than the Delta variant to escape vaccines, 2021, bioRxiv (Cold Spring Harbor Laboratory)

John W. Kappler has received several awards and honors, including:

Distinguished Fellows of the American Association of Immunologists (AAI), 2020
Member of the National Academy of Medicine (NAM), 2008
Louisa Gross Horwitz Prize, Columbia University, 1994
Paul Ehrlich and Ludwig Darmstaedter Prize, 1993
Member of the National Academy of Sciences, 1989

Best Publications

T cell tolerance by clonal elimination in the thymus

John W. Kappler;Neal Roehm;Philippa Marrack

3268
Citations
The staphylococcal enterotoxins and their relatives

Philippa Marrack;John Kappler

2932
Citations
The Vβ-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletion in neonatal mice

Janice White;Andrew Herman;Ann M. Pullen;Ralph Kubo

1521
Citations
Characterization of the Murine Antigenic Determinant, Designated L3T4a, Recognized by Monoclonal Antibody GK 1.5: Expression of L3T4a by Functional T Cell Clones Appears to Correlate Primarily with Class II MHC Antigen‐Reactivity

D. P. Dialynas;D. B. Wilde;P. Marrack;A. Pierres

1441
Citations
Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition

John W. Kappler;Barry Skidmore;Janice White;Philippa Marrack

1435
Citations
Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex

John W. Kappler;Uwe Staerz;Janice White;Philippa C. Marrack;Philippa C. Marrack

1430
Citations
Interaction of Staphylococcus aureus toxin "superantigens" with human T cells.

Yongwon Choi;Brian Kotzin;Lynne Herron;Jill Callahan

1424
Citations
Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells

Beverly H. Koller;Philippa Marrack;John W. Kappler;Oliver Smithies

1277
Citations
The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody.

K Haskins;R Kubo;J White;M Pigeon

1201
Citations
Type I Interferons Keep Activated T Cells Alive

Philippa Marrack;John Kappler;Tom Mitchell

1166
Citations
Superantigens: Mechanism of T-Cell Stimulation and Role in Immune Responses

Andrew Herman;John W. Kappler;Philippa Marrack;Ann M. Pullen

1093
Citations
Control of Homeostasis of CD8+ Memory T Cells by Opposing Cytokines

Chia Chi Ku;Masaaki Murakami;Akemi Sakamoto;John Kappler

1063
Citations
Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors.

R T Kubo;W Born;J W Kappler;P Marrack

1052
Citations
Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing.

R Shimonkevitz;J Kappler;P Marrack;H Grey

969
Citations
Toll-like receptor 7 (TLR7)–driven accumulation of a novel CD11c+ B-cell population is important for the development of autoimmunity

Anatoly V. Rubtsov;Kira Rubtsova;Aryeh Fischer;Richard T. Meehan

937
Citations
Vβ-specific stimulation of human T cells by staphylococcal toxins

John Kappler;Brian Kotzin;Lynne Herron;Erwin W. Gelfand

909
Citations
Superantigens and their potential role in human disease.

Brian L. Kotzin;Donald Y.M. Leung;John Kappler;John Kappler;Philippa Marrack;Philippa Marrack

892
Citations
An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder.

Michael B. Jordan;David Hildeman;John Kappler;Philippa Marrack

825
Citations
The role of the T cell receptor in positive and negative selection of developing T cells

Marcia A. Blackman;John W. Kappler;Philippa Marrack

795
Citations
Evidence for the effects of a superantigen in rheumatoid arthritis

Xavier Paliard;Sterling G. West;Joyce A. Lafferty;Janice R. Clements

789
Citations
The antigen-specific, major histocompatibility complex-restricted receptor on T cells. VI. An antibody to a receptor allotype.

K Haskins;C Hannum;J White;N Roehm

496
Citations
A role for clonal inactivation in T cell tolerance to Mls-1a.

Marcia A. Blackman;Hans Gerhard-Burgert;David L. Woodland;Ed Palmer

223
Citations

Frequent Co-Authors

Philippa Marrack National Jewish Health

Janice White Howard Hughes Medical Institute

Ralph T. Kubo Johns Hopkins University

Brian L. Kotzin University of Colorado Anschutz Medical Campus

Yongwon Choi University of Pennsylvania

Laurent Gapin University of Colorado Anschutz Medical Campus

David A. Hildeman Cincinnati Children's Hospital Medical Center

Andrew P. Fontenot University of Colorado Anschutz Medical Campus

Kathryn Haskins University of Colorado Denver

Marcia A. Blackman Trudeau Institute

External Links

Personal website of John W. Kappler

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