D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Immunology D-index 130 Citations 64,636 360 World Ranking 79 National Ranking 55

Research.com Recognitions

Awards & Achievements

2020 - Distinguished Fellows of the American Association of Immunologists (AAI)

2008 - Member of the National Academy of Medicine (NAM)

1994 - Louisa Gross Horwitz Prize, Columbia University

1993 - Paul Ehrlich and Ludwig Darmstaedter Prize

1989 - Member of the National Academy of Sciences

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Immune system
  • Antigen

His primary areas of investigation include T cell, Antigen, Cytotoxic T cell, Major histocompatibility complex and Molecular biology. His T cell study contributes to a more complete understanding of Immunology. The various areas that John W. Kappler examines in his Antigen study include Biochemistry and B cell.

His Major histocompatibility complex study combines topics from a wide range of disciplines, such as Receptor and T-cell receptor. John W. Kappler has included themes like Superantigen and Virology in his T-cell receptor study. His study in Molecular biology is interdisciplinary in nature, drawing from both Cell culture, Lymphokine and Monoclonal antibody.

His most cited work include:

  • T cell tolerance by clonal elimination in the thymus (1954 citations)
  • The staphylococcal enterotoxins and their relatives (1725 citations)
  • The Vβ-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletion in neonatal mice (911 citations)

What are the main themes of his work throughout his whole career to date?

His primary scientific interests are in T cell, Antigen, Molecular biology, Immunology and Major histocompatibility complex. His work carried out in the field of T cell brings together such families of science as Cytotoxic T cell, B cell and Cell biology. The study incorporates disciplines such as Apoptosis and Cell in addition to Cell biology.

His Antigen research is multidisciplinary, incorporating elements of Antibody and Antigen presentation. His Molecular biology research includes elements of Cell culture, Lymphokine, Gene, Interleukin 2 and Monoclonal antibody. His Major histocompatibility complex research incorporates themes from Peptide and T-cell receptor.

He most often published in these fields:

  • T cell (62.11%)
  • Antigen (53.33%)
  • Molecular biology (51.05%)

What were the highlights of his more recent work (between 2011-2021)?

  • Antigen (53.33%)
  • T-cell receptor (40.00%)
  • T cell (62.11%)

In recent papers he was focusing on the following fields of study:

John W. Kappler mainly focuses on Antigen, T-cell receptor, T cell, Molecular biology and Immunology. His work deals with themes such as Adjuvant, Immune system, Peptide and Cell biology, which intersect with Antigen. John W. Kappler combines subjects such as Tolerance induction and MHC class II with his study of Cell biology.

The concepts of his T-cell receptor study are interwoven with issues in Cell culture, Receptor, Peptide sequence, Major histocompatibility complex and Berylliosis. In his work, CD8 and Virology is strongly intertwined with Cytotoxic T cell, which is a subfield of T cell. He works mostly in the field of Molecular biology, limiting it down to topics relating to Acquired immune system and, in certain cases, Inflammation.

Between 2011 and 2021, his most popular works were:

  • T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance (134 citations)
  • Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes (101 citations)
  • B cells expressing the transcription factor T-bet drive lupus-like autoimmunity (95 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Immune system
  • Antigen

Immunology, Antigen, T-cell receptor, T cell and Molecular biology are his primary areas of study. John W. Kappler interconnects Antigen presentation and Berylliosis in the investigation of issues within Antigen. His T-cell receptor research is multidisciplinary, incorporating perspectives in Cell culture, Receptor, Ligand and Natural killer T cell, CD8.

His T cell research is multidisciplinary, relying on both Beryllium Disease, Preproinsulin, Proinsulin, Pancreas and Pancreatic islets. His Molecular biology study integrates concerns from other disciplines, such as Cytotoxic T cell, Antibody, MHC class II and Cell biology. His research in Cell biology intersects with topics in Adjuvant and Dendritic cell.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

T cell tolerance by clonal elimination in the thymus

John W. Kappler;Neal Roehm;Philippa Marrack.
Cell (1987)

3192 Citations

The staphylococcal enterotoxins and their relatives

Philippa Marrack;John Kappler.
Science (1990)

2748 Citations

Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex

John W. Kappler;Uwe Staerz;Janice White;Philippa C. Marrack;Philippa C. Marrack.
Nature (1988)

1424 Citations

The Vβ-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletion in neonatal mice

Janice White;Andrew Herman;Ann M. Pullen;Ralph Kubo.
Cell (1989)

1416 Citations

Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition

John W. Kappler;Barry Skidmore;Janice White;Philippa Marrack.
Journal of Experimental Medicine (1981)

1402 Citations

Interaction of Staphylococcus aureus toxin "superantigens" with human T cells.

Yongwon Choi;Brian Kotzin;Lynne Herron;Jill Callahan.
Proceedings of the National Academy of Sciences of the United States of America (1989)

1376 Citations

Characterization of the Murine Antigenic Determinant, Designated L3T4a, Recognized by Monoclonal Antibody GK 1.5: Expression of L3T4a by Functional T Cell Clones Appears to Correlate Primarily with Class II MHC Antigen‐Reactivity

D. P. Dialynas;D. B. Wilde;P. Marrack;A. Pierres.
Immunological Reviews (1983)

1350 Citations

Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells

Beverly H. Koller;Philippa Marrack;John W. Kappler;Oliver Smithies.
Science (1990)

1206 Citations

The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody.

K Haskins;R Kubo;J White;M Pigeon.
Journal of Experimental Medicine (1983)

1199 Citations

Type I Interferons Keep Activated T Cells Alive

Philippa Marrack;John Kappler;Tom Mitchell.
Journal of Experimental Medicine (1999)

1109 Citations

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