2020 - Distinguished Fellows of the American Association of Immunologists (AAI)
2008 - Member of the National Academy of Medicine (NAM)
1994 - Louisa Gross Horwitz Prize, Columbia University
1993 - Paul Ehrlich and Ludwig Darmstaedter Prize
1989 - Member of the National Academy of Sciences
His primary areas of investigation include T cell, Antigen, Cytotoxic T cell, Major histocompatibility complex and Molecular biology. His T cell study contributes to a more complete understanding of Immunology. The various areas that John W. Kappler examines in his Antigen study include Biochemistry and B cell.
His Major histocompatibility complex study combines topics from a wide range of disciplines, such as Receptor and T-cell receptor. John W. Kappler has included themes like Superantigen and Virology in his T-cell receptor study. His study in Molecular biology is interdisciplinary in nature, drawing from both Cell culture, Lymphokine and Monoclonal antibody.
His primary scientific interests are in T cell, Antigen, Molecular biology, Immunology and Major histocompatibility complex. His work carried out in the field of T cell brings together such families of science as Cytotoxic T cell, B cell and Cell biology. The study incorporates disciplines such as Apoptosis and Cell in addition to Cell biology.
His Antigen research is multidisciplinary, incorporating elements of Antibody and Antigen presentation. His Molecular biology research includes elements of Cell culture, Lymphokine, Gene, Interleukin 2 and Monoclonal antibody. His Major histocompatibility complex research incorporates themes from Peptide and T-cell receptor.
John W. Kappler mainly focuses on Antigen, T-cell receptor, T cell, Molecular biology and Immunology. His work deals with themes such as Adjuvant, Immune system, Peptide and Cell biology, which intersect with Antigen. John W. Kappler combines subjects such as Tolerance induction and MHC class II with his study of Cell biology.
The concepts of his T-cell receptor study are interwoven with issues in Cell culture, Receptor, Peptide sequence, Major histocompatibility complex and Berylliosis. In his work, CD8 and Virology is strongly intertwined with Cytotoxic T cell, which is a subfield of T cell. He works mostly in the field of Molecular biology, limiting it down to topics relating to Acquired immune system and, in certain cases, Inflammation.
Immunology, Antigen, T-cell receptor, T cell and Molecular biology are his primary areas of study. John W. Kappler interconnects Antigen presentation and Berylliosis in the investigation of issues within Antigen. His T-cell receptor research is multidisciplinary, incorporating perspectives in Cell culture, Receptor, Ligand and Natural killer T cell, CD8.
His T cell research is multidisciplinary, relying on both Beryllium Disease, Preproinsulin, Proinsulin, Pancreas and Pancreatic islets. His Molecular biology study integrates concerns from other disciplines, such as Cytotoxic T cell, Antibody, MHC class II and Cell biology. His research in Cell biology intersects with topics in Adjuvant and Dendritic cell.
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T cell tolerance by clonal elimination in the thymus
John W. Kappler;Neal Roehm;Philippa Marrack.
The staphylococcal enterotoxins and their relatives
Philippa Marrack;John Kappler.
Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex
John W. Kappler;Uwe Staerz;Janice White;Philippa C. Marrack;Philippa C. Marrack.
The Vβ-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletion in neonatal mice
Janice White;Andrew Herman;Ann M. Pullen;Ralph Kubo.
Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition
John W. Kappler;Barry Skidmore;Janice White;Philippa Marrack.
Journal of Experimental Medicine (1981)
Interaction of Staphylococcus aureus toxin "superantigens" with human T cells.
Yongwon Choi;Brian Kotzin;Lynne Herron;Jill Callahan.
Proceedings of the National Academy of Sciences of the United States of America (1989)
Characterization of the Murine Antigenic Determinant, Designated L3T4a, Recognized by Monoclonal Antibody GK 1.5: Expression of L3T4a by Functional T Cell Clones Appears to Correlate Primarily with Class II MHC Antigen‐Reactivity
D. P. Dialynas;D. B. Wilde;P. Marrack;A. Pierres.
Immunological Reviews (1983)
Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells
Beverly H. Koller;Philippa Marrack;John W. Kappler;Oliver Smithies.
The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody.
K Haskins;R Kubo;J White;M Pigeon.
Journal of Experimental Medicine (1983)
Type I Interferons Keep Activated T Cells Alive
Philippa Marrack;John Kappler;Tom Mitchell.
Journal of Experimental Medicine (1999)
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