Jonathan Sprent

Research.com Recognitions

• 2026 - Research.com Immunology in Australia Leader Award
• 2025 - Research.com Immunology in Australia Leader Award
• 2023 - Research.com Immunology in Australia Leader Award
• 2022 - Research.com Immunology in Australia Leader Award
• 2019 - Distinguished Fellows of the American Association of Immunologists (AAI)
• 2017 - Member of the National Academy of Sciences
• 2015 - AAI Lifetime Achievement Award, American Association of Immunologists
• 1998 - Fellow of the Royal Society, United Kingdom

Overview

Best Publications

• The role of interleukin-2 during homeostasis and activation of the immune system.

  Onur Boyman;Jonathan Sprent;Jonathan Sprent

  2054
  Citations

• Potent and Selective Stimulation of Memory-Phenotype CD8+ T Cells In Vivo by IL-15

  Xiaohong Zhang;Siquan Sun;Inkyu Hwang;David F Tough

  1560
  Citations

• Homeostasis of naive and memory T cells.

  Charles D. Surh;Jonathan Sprent

  1513
  Citations

• T-cell apoptosis detected in situ during positive and negative selection in the thymus

  Charles D. Surh;Jonathan Sprent

  1367
  Citations

• Induction of Bystander T Cell Proliferation by Viruses and Type I Interferon in Vivo

  David F. Tough;Persephone Borrow;Jonathan Sprent

  1351
  Citations

• IL-7 is critical for homeostatic proliferation and survival of naïve T cells

  Joyce T. Tan;Eric Dudl;Eric LeRoy;Richard Murray

  1212
  Citations

• Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection.

  Ganesh A. Kolumam;Sunil Thomas;Lucas J. Thompson;Jonathan Sprent

  1180
  Citations

• Turnover of naive- and memory-phenotype T cells.

  David F. Tough;Jonathan Sprent

  1104
  Citations

• Extrathymic tolerance of mature T cells: clonal elimination as a consequence of immunity.

  Susan Webb;Claudia Morris;Jonathan Sprent

  1098
  Citations

• Selective stimulation of T cell subsets with antibody-cytokine immune complexes

  Onur Boyman;Marek Kovar;Marek Kovar;Mark P. Rubinstein;Mark P. Rubinstein;Charles D. Surh;Charles D. Surh

  1028
  Citations

• Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells.

  Joyce T. Tan;Bettina Ernst;William C. Kieper;Eric M. Leroy

  1010
  Citations

• The Peptide Ligands Mediating Positive Selection in the Thymus Control T Cell Survival and Homeostatic Proliferation in the Periphery

  Bettina Ernst;Dong-Sup Lee;Jennifer M Chang;Jonathan Sprent

  930
  Citations

• A Fundamental Role for Interleukin-21 in the Generation of T Follicular Helper Cells

  Alexis Vogelzang;Helen N McGuire;Di Yu;Jonathon Sprent

  893
  Citations

• Lethal graft-versus-host disease after bone marrow transplantation across minor histocompatibility barriers in mice. Prevention by removing mature T cells from marrow.

  R Korngold;J Sprent

  742
  Citations

• A monoclonal antibody discriminating between subsets of T and B cells.

  J Bruce;F W Symington;T J McKearn;J Sprent

  700
  Citations

• Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells

  Jonathan Sprent;Charles D Surh;Charles D Surh

  631
  Citations

• In vivo expansion of T reg cells with IL-2–mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression

  Kylie E. Webster;Stacey Walters;Rachel E. Kohler;Tomas Mrkvan

  610
  Citations

• A RECEPTOR FOR ANTIBODY ON B LYMPHOCYTES : I. METHOD OF DETECTION AND FUNCTIONAL SIGNIFICANCE

  A. Basten;J. F. A. P. Miller;J. Sprent;J. Pye

  606
  Citations

• TCR-mediated internalization of peptide-MHC complexes acquired by T cells

  Jing-Feng Huang;Young Yang;Homero Sepulveda;Weixing Shi

  599
  Citations

• Lymphocyte life-span and memory

  Jonathan Sprent;David F. Tough

  554
  Citations