What is he best known for?
The fields of study he is best known for:
- Gene
- Immune system
- Cytokine
David F. Tough mostly deals with Immunology, Cell biology, T cell, Cytotoxic T cell and CD8.
His Immunology research is multidisciplinary, relying on both Bromodeoxyuridine and Lymphoblast.
His work deals with themes such as Dendritic cell and Immune system, which intersect with Cell biology.
His studies examine the connections between T cell and genetics, as well as such issues in Stimulation, with regards to Lipopolysaccharide, Interleukin 12, Antibody response and Receptor.
His Cytotoxic T cell study focuses mostly on IL-2 receptor and Antigen-presenting cell.
He has included themes like Molecular biology, Interleukin 15, Interferon and CD40 in his CD8 study.
His most cited work include:
- Potent and Selective Stimulation of Memory-Phenotype CD8+ T Cells In Vivo by IL-15 (1142 citations)
- Induction of Bystander T Cell Proliferation by Viruses and Type I Interferon in Vivo (970 citations)
- Type i interferons potently enhance humoral immunity and can promote isotype switching by stimulating dendritic cells in vivo. (869 citations)
What are the main themes of his work throughout his whole career to date?
David F. Tough mainly investigates Immunology, Cell biology, Immune system, T cell and CD8.
The Immunology study combines topics in areas such as Cytotoxic T cell and Virology.
In his study, Cellular differentiation, Priming and Spleen is inextricably linked to Dendritic cell, which falls within the broad field of Cell biology.
His studies in T cell integrate themes in fields like Cell, Enhancer, Molecular biology, Receptor and C-C chemokine receptor type 7.
His CD8 research is multidisciplinary, incorporating elements of Lymphocyte, Interferon, Interleukin 15 and In vivo.
The concepts of his Antigen-presenting cell study are interwoven with issues in Natural killer T cell and IL-2 receptor.
He most often published in these fields:
- Immunology (49.19%)
- Cell biology (35.48%)
- Immune system (31.45%)
What were the highlights of his more recent work (between 2017-2021)?
- Immune system (31.45%)
- Cell biology (35.48%)
- T cell (28.23%)
In recent papers he was focusing on the following fields of study:
His primary scientific interests are in Immune system, Cell biology, T cell, Gene expression and Immunology.
His Immune system research incorporates elements of Epigenetics and Cytokine.
In his study, which falls under the umbrella issue of Cytokine, Antigen is strongly linked to Inflammation.
David F. Tough has included themes like Tumor necrosis factor alpha, Cell, Lipopolysaccharide, Chemokine and CD14 in his Cell biology study.
David F. Tough works mostly in the field of T cell, limiting it down to topics relating to Chromatin and, in certain cases, Regulation of gene expression.
His research in Immunology intersects with topics in Crohn's disease and HDAC3.
Between 2017 and 2021, his most popular works were:
- Selective targeting of BD1 and BD2 of the BET proteins in cancer and immuno-inflammation. (65 citations)
- Modulating PCAF/GCN5 Immune Cell Function through a PROTAC Approach (51 citations)
- Chromatin activity at GWAS loci identifies T cell states driving complex immune diseases. (24 citations)
In his most recent research, the most cited papers focused on:
- Gene
- Immune system
- Cytokine
His primary areas of investigation include Cell biology, T cell, Enhancer, Bromodomain and Chromatin.
His Cell biology study combines topics in areas such as Inflammation, Immune system and Antigen.
His T cell research is multidisciplinary, incorporating perspectives in Cytokine, Single-cell analysis, Chemokine, Chromatin remodeling and Cell type.
His research integrates issues of Cell, Disease, Homeostasis and Cell quiescence in his study of Enhancer.
In his research, Transcription factor is intimately related to Cancer research, which falls under the overarching field of Bromodomain.
His biological study spans a wide range of topics, including HEK 293 cells, Regulation of gene expression and BRD4.
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