2026 David F. Tough: Immunology Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Immunology	68	2552	2346	223	216	137	23199

David F. Tough publication distribution in Immunology in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Immunology in 2026. The highlighted bar marks where David F. Tough sits on this spectrum.

62 publications 807+

This scientist: 137 publications — 12th percentile

12% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 807 publications or more.

David F. Tough D-index placement in Immunology in 2026

The chart shows the D-index (discipline H-index) distribution of Immunology scientists ranked by Research.com in 2026. The highlighted bar marks where David F. Tough sits on this spectrum.

40 D-Index 157+

This scientist: 68 D-Index — 49th percentile

49% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 157 D-Index or more.

Overview

David F. Tough is affiliated with GlaxoSmithKline in the United Kingdom. Their research primarily spans the fields of Immunology and Microbiology, Biochemistry, Genetics and Molecular Biology, and Medicine.

The scientist's work is concentrated in several subfields, including Immunology, Molecular Biology, Rheumatology, Pathology and Forensic Medicine, and Virology. Their research topics cover:

Immune Cell Function and Interaction
T-cell and B-cell Immunology
Protein Degradation and Inhibitors
Single-cell and spatial transcriptomics
Immune cells in cancer
Histone Deacetylase Inhibitors Research
Immunotherapy and Immune Responses

Recent notable publications authored or co-authored by David F. Tough include:

"Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation," 2020, Science
"Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines," 2020, Nature Communications
"Immune disease risk variants regulate gene expression dynamics during CD4+ T cell activation," 2022, Nature Genetics
"BACH2 drives quiescence and maintenance of resting Treg cells to promote homeostasis and cancer immunosuppression," 2020, The Journal of Experimental Medicine
"HDAC3 Mediates the Inflammatory Response and LPS Tolerance in Human Monocytes and Macrophages," 2020, Frontiers in Immunology

The scientist frequently publishes in several venues, including bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Frontiers in Immunology, Annals of the Rheumatic Diseases, and Zenodo (CERN European Organization for Nuclear Research).

David F. Tough has collaborated frequently with several co-authors, notably:

Rab K. Prinjha
Nicola Harker
Wouter J. de Jonge
Gosia Trynka
Mohammed Ghiboub

Best Publications

Potent and Selective Stimulation of Memory-Phenotype CD8+ T Cells In Vivo by IL-15

Xiaohong Zhang;Siquan Sun;Inkyu Hwang;David F Tough

1560
Citations
Induction of Bystander T Cell Proliferation by Viruses and Type I Interferon in Vivo

David F. Tough;Persephone Borrow;Jonathan Sprent

1351
Citations
Type i interferons potently enhance humoral immunity and can promote isotype switching by stimulating dendritic cells in vivo.

Agnes Le Bon;Giovanna Schiavoni;Giuseppina D'Agostino;Ion Gresser

1208
Citations
Turnover of naive- and memory-phenotype T cells.

David F. Tough;Jonathan Sprent

1104
Citations
Cross-priming of CD8 + T cells stimulated by virus-induced type I interferon

Agnes Le Bon;Nathalie Etchart;Nathalie Etchart;Cornelia Rossmann;Miranda Ashton

1022
Citations
Links between innate and adaptive immunity via type I interferon

Agnes Le Bon;David F Tough

851
Citations
Type I interferons produced by dendritic cells promote their phenotypic and functional activation.

Maria Montoya;Giovanna Schiavoni;Fabrizio Mattei;Ion Gresser

688
Citations
Initial T cell frequency dictates memory CD8+ T cell lineage commitment.

Amanda L Marzo;Kimberly D Klonowski;Agnes Le Bon;Persephone Borrow

576
Citations
IL-15 is expressed by dendritic cells in response to type I IFN, double-stranded RNA, or lipopolysaccharide and promotes dendritic cell activation.

Fabrizio Mattei;Giovanna Schiavoni;Filippo Belardelli;David F. Tough

571
Citations
Developmental kinetics and lifespan of dendritic cells in mouse lymphoid organs.

Arun T. Kamath;Sandrine Henri;Frank Battye;David F. Tough

558
Citations
Lymphocyte life-span and memory

Jonathan Sprent;David F. Tough

554
Citations
The development, maturation, and turnover rate of mouse spleen dendritic cell populations

Arun T. Kamath;Joanne Pooley;Meredith A. O’Keeffe;David Vremec

509
Citations
Type I Interferon-mediated Stimulation of T Cells by CpG DNA

Siquan Sun;Xiaohong Zhang;David F. Tough;Jonathan Sprent

476
Citations
IL-15 Promotes the Survival of Naive and Memory Phenotype CD8+ T Cells

Marion Berard;Katja Brandt;Silvia Bulfone-Paus;David F. Tough

446
Citations
Cutting edge: enhancement of antibody responses through direct stimulation of B and T cells by type I IFN.

Agnes Le Bon;Clare Thompson;Elisabeth Kamphuis;Vanessa Durand

444
Citations
In vivo kinetics of human natural killer cells: the effects of ageing and acute and chronic viral infection

Yan Zhang;Diana L. Wallace;Catherine M. De Lara;Hala Ghattas

422
Citations
T Cell Stimulation In Vivo by Lipopolysaccharide (LPS)

David F. Tough;Siquan Sun;Jonathan Sprent

406
Citations
Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation

Omer Gilan;Omer Gilan;Inmaculada Rioja;Kathy Knezevic;Matthew J. Bell

402
Citations
Direct stimulation of T cells by type I IFN enhances the CD8+ T cell response during cross-priming.

Agnes Le Bon;Vanessa Durand;Elisabeth Kamphuis;Clare Thompson

391
Citations
Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines

Eddie Cano-Gamez;Blagoje Soskic;Theodoros I. Roumeliotis;Ernest So

310
Citations
T cell death and memory.

Jonathan Sprent;David F. Tough

284
Citations

Frequent Co-Authors

Jonathan Sprent Garvan Institute of Medical Research

Rab K. Prinjha GlaxoSmithKline (United Kingdom)

Jagadeesh Bayry Indian Institute of Technology Palakkad

Filippo Belardelli National Research Council (CNR)

Persephone Borrow University of Oxford

Peter C. L. Beverley Jenner Institute

Srini V. Kaveri Centre national de la recherche scientifique, CNRS

Paul P. Tak GlaxoSmithKline (United Kingdom)

Becca Asquith Imperial College London

George E. Griffin St George's, University of London

External Links

Personal website of David F. Tough

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