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Immunology

D-Index
68
Citations
23199
World Ranking
2552
National Ranking
223

Overview

David F. Tough is affiliated with GlaxoSmithKline in the United Kingdom. Their research primarily spans the fields of Immunology and Microbiology, Biochemistry, Genetics and Molecular Biology, and Medicine.

The scientist's work is concentrated in several subfields, including Immunology, Molecular Biology, Rheumatology, Pathology and Forensic Medicine, and Virology. Their research topics cover:

  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Protein Degradation and Inhibitors
  • Single-cell and spatial transcriptomics
  • Immune cells in cancer
  • Histone Deacetylase Inhibitors Research
  • Immunotherapy and Immune Responses

Recent notable publications authored or co-authored by David F. Tough include:

  • "Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation," 2020, Science
  • "Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines," 2020, Nature Communications
  • "Immune disease risk variants regulate gene expression dynamics during CD4+ T cell activation," 2022, Nature Genetics
  • "BACH2 drives quiescence and maintenance of resting Treg cells to promote homeostasis and cancer immunosuppression," 2020, The Journal of Experimental Medicine
  • "HDAC3 Mediates the Inflammatory Response and LPS Tolerance in Human Monocytes and Macrophages," 2020, Frontiers in Immunology

The scientist frequently publishes in several venues, including bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Frontiers in Immunology, Annals of the Rheumatic Diseases, and Zenodo (CERN European Organization for Nuclear Research).

David F. Tough has collaborated frequently with several co-authors, notably:

  • Rab K. Prinjha
  • Nicola Harker
  • Wouter J. de Jonge
  • Gosia Trynka
  • Mohammed Ghiboub

Best Publications

  • Potent and Selective Stimulation of Memory-Phenotype CD8+ T Cells In Vivo by IL-15

    Xiaohong Zhang;Siquan Sun;Inkyu Hwang;David F Tough

  • Induction of Bystander T Cell Proliferation by Viruses and Type I Interferon in Vivo

    David F. Tough;Persephone Borrow;Jonathan Sprent

  • Type i interferons potently enhance humoral immunity and can promote isotype switching by stimulating dendritic cells in vivo.

    Agnes Le Bon;Giovanna Schiavoni;Giuseppina D'Agostino;Ion Gresser

  • Turnover of naive- and memory-phenotype T cells.

    David F. Tough;Jonathan Sprent

  • Cross-priming of CD8 + T cells stimulated by virus-induced type I interferon

    Agnes Le Bon;Nathalie Etchart;Nathalie Etchart;Cornelia Rossmann;Miranda Ashton

  • Links between innate and adaptive immunity via type I interferon

    Agnes Le Bon;David F Tough

  • Type I interferons produced by dendritic cells promote their phenotypic and functional activation.

    Maria Montoya;Giovanna Schiavoni;Fabrizio Mattei;Ion Gresser

  • Initial T cell frequency dictates memory CD8+ T cell lineage commitment.

    Amanda L Marzo;Kimberly D Klonowski;Agnes Le Bon;Persephone Borrow

  • IL-15 is expressed by dendritic cells in response to type I IFN, double-stranded RNA, or lipopolysaccharide and promotes dendritic cell activation.

    Fabrizio Mattei;Giovanna Schiavoni;Filippo Belardelli;David F. Tough

  • Developmental kinetics and lifespan of dendritic cells in mouse lymphoid organs.

    Arun T. Kamath;Sandrine Henri;Frank Battye;David F. Tough

  • Lymphocyte life-span and memory

    Jonathan Sprent;David F. Tough

  • The development, maturation, and turnover rate of mouse spleen dendritic cell populations

    Arun T. Kamath;Joanne Pooley;Meredith A. O’Keeffe;David Vremec

  • Type I Interferon-mediated Stimulation of T Cells by CpG DNA

    Siquan Sun;Xiaohong Zhang;David F. Tough;Jonathan Sprent

  • IL-15 Promotes the Survival of Naive and Memory Phenotype CD8+ T Cells

    Marion Berard;Katja Brandt;Silvia Bulfone-Paus;David F. Tough

  • Cutting edge: enhancement of antibody responses through direct stimulation of B and T cells by type I IFN.

    Agnes Le Bon;Clare Thompson;Elisabeth Kamphuis;Vanessa Durand

  • In vivo kinetics of human natural killer cells: the effects of ageing and acute and chronic viral infection

    Yan Zhang;Diana L. Wallace;Catherine M. De Lara;Hala Ghattas

  • T Cell Stimulation In Vivo by Lipopolysaccharide (LPS)

    David F. Tough;Siquan Sun;Jonathan Sprent

  • Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation

    Omer Gilan;Omer Gilan;Inmaculada Rioja;Kathy Knezevic;Matthew J. Bell

  • Direct stimulation of T cells by type I IFN enhances the CD8+ T cell response during cross-priming.

    Agnes Le Bon;Vanessa Durand;Elisabeth Kamphuis;Clare Thompson

  • Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines

    Eddie Cano-Gamez;Blagoje Soskic;Theodoros I. Roumeliotis;Ernest So

  • T cell death and memory.

    Jonathan Sprent;David F. Tough

Frequent Co-Authors

Jonathan Sprent
Jonathan Sprent Garvan Institute of Medical Research
Rab K. Prinjha
Rab K. Prinjha GlaxoSmithKline (United Kingdom)
Jagadeesh Bayry
Jagadeesh Bayry Indian Institute of Technology Palakkad
Filippo Belardelli
Filippo Belardelli National Research Council (CNR)
Persephone Borrow
Persephone Borrow University of Oxford
Peter C. L. Beverley
Peter C. L. Beverley Jenner Institute
Srini V. Kaveri
Srini V. Kaveri Centre national de la recherche scientifique, CNRS
Paul P. Tak
Paul P. Tak GlaxoSmithKline (United Kingdom)
Becca Asquith
Becca Asquith Imperial College London
George E. Griffin
George E. Griffin St George's, University of London

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