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Immunology

D-Index
59
Citations
15638
World Ranking
3399
National Ranking
1576

Overview

David A. Hildeman is affiliated with Cincinnati Children's Hospital Medical Center in the United States. Their research spans significant areas within medicine, particularly focusing on immunology and microbiology. Their work includes extensive contributions to subfields such as immunology, molecular biology, transplantation, oncology, and epidemiology.

The scientist's research addresses various topics, including immune cell function and interaction, T-cell and B-cell immunology, renal transplantation outcomes and treatments, systemic lupus erythematosus research, immunotherapy and immune responses, liver diseases and immunity, and atherosclerosis and cardiovascular diseases.

Frequent coauthors collaborating with David A. Hildeman include E. Steve Woodle, Claire Chougnet, Tiffany Shi, Krishna M. Roskin, and Emily R. Miraldi.

Their work has been published across several prominent venues, with a majority of publications appearing in bioRxiv (Cold Spring Harbor Laboratory), followed by American Journal of Transplantation, The Journal of Immunology, Science Advances, and Frontiers in Immunology.

Among recent papers authored by or involving David A. Hildeman are:

  • Apoptotic cell death in disease-Current understanding of the NCCD 2023 (2023), published in Cell Death and Differentiation
  • IL-10-producing Tfh cells accumulate with age and link inflammation with age-related immune suppression (2020), published in Science Advances
  • Naturally-aged microglia exhibit phagocytic dysfunction accompanied by gene expression changes reflective of underlying neurologic disease (2022), published in Scientific Reports
  • Single-cell transcriptomic analysis of renal allograft rejection reveals insights into intragraft TCR clonality (2023), published in Journal of Clinical Investigation
  • Farnesoid X receptor antagonizes macrophage-dependent licensing of effector T lymphocytes and progression of sclerosing cholangitis (2022), published in Science Translational Medicine

Best Publications

  • Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling

    Laura A. Sena;Sha Li;Amit Jairaman;Murali Prakriya

  • An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder.

    Michael B. Jordan;David Hildeman;John Kappler;Philippa Marrack

  • The immune cell landscape in kidneys of patients with lupus nephritis

    Arnon Arazi;Deepak A Rao;Celine C Berthier;Anne Davidson

  • Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim.

    David A Hildeman;Yanan Zhu;Thomas C Mitchell;Philippe Bouillet

  • Reactive Oxygen Species Regulate Activation-Induced T Cell Apoptosis

    David A Hildeman;Tom Mitchell;T.Kent Teague;Peter Henson

  • Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils

    Shyra J. Gardai;David A. Hildeman;Steve K. Frankel;Ben B. Whitlock

  • T cells compete for access to antigen-bearing antigen-presenting cells

    Ross M. Kedl;William A. Rees;David A. Hildeman;Brian Schaefer

  • Functional Regulatory T Cells Accumulate in Aged Hosts and Promote Chronic Infectious Disease Reactivation

    Celine S. Lages;Isabelle Suffia;Paula A. Velilla;Bin Huang

  • IL-7 Promotes T Cell Viability, Trafficking, and Functionality and Improves Survival in Sepsis

    Jacqueline Unsinger;Margaret McGlynn;Kevin R. Kasten;Kevin R. Kasten;Andrew S. Hoekzema

  • Homeostasis of alpha beta TCR+ T cells.

    Philippa Marrack;Jeremy Bender;David Hildeman;Michael Jordan

  • Nonredundant Roles for B Cell-Derived IL-10 in Immune Counter-Regulation

    Rajat Madan;Filiz Demircik;Sangeetha Surianarayanan;Jessica L. Allen

  • Molecular mechanisms of activated T cell death in vivo

    David A Hildeman;Yanan Zhu;Thomas C Mitchell;Thomas C Mitchell;John Kappler

  • Control of Bcl-2 expression by reactive oxygen species

    David A. Hildeman;Thomas Mitchell;Bruce Aronow;Sara Wojciechowski

  • C5a negatively regulates toll-like receptor 4-induced immune responses.

    Heiko Hawlisch;Yasmine Belkaid;Ralf Baelder;David Hildeman

  • Immunological adjuvants promote activated T cell survival via induction of Bcl-3.

    Thomas C. Mitchell;Thomas C. Mitchell;David Hildeman;Ross M. Kedl;T. Kent Teague;T. Kent Teague

  • Activation changes the spectrum but not the diversity of genes expressed by T cells.

    T. Kent Teague;David Hildeman;Ross M. Kedl;Tom Mitchell

  • Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis.

    Sara Wojciechowski;Pulak Tripathi;Tristan Bourdeau;Luis Acero

  • Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3 + regulatory T cells

    Wim Pierson;Bénédicte Cauwe;Antonia Policheni;Antonia Policheni;Susan M Schlenner

  • Etoposide Selectively Ablates Activated T Cells To Control the Immunoregulatory Disorder Hemophagocytic Lymphohistiocytosis

    Theodore S. Johnson;Catherine E. Terrell;Scott H. Millen;Jonathan D. Katz

  • T cell apoptosis and reactive oxygen species

    David A. Hildeman;Thomas Mitchell;John Kappler;Philippa Marrack

Frequent Co-Authors

Philippa Marrack
Philippa Marrack National Jewish Health
Claire A. Chougnet
Claire A. Chougnet Cincinnati Children's Hospital Medical Center
John W. Kappler
John W. Kappler National Jewish Health
Michael B. Jordan
Michael B. Jordan Cincinnati Children's Hospital Medical Center
Fred D. Finkelman
Fred D. Finkelman University of Cincinnati
H. Leighton Grimes
H. Leighton Grimes Cincinnati Children's Hospital Medical Center
Charles C. Caldwell
Charles C. Caldwell University of Cincinnati
E. Steve Woodle
E. Steve Woodle University of Cincinnati Medical Center
Kasper Hoebe
Kasper Hoebe Johnson & Johnson (United States)
Suzanne C. Morris
Suzanne C. Morris University of Cincinnati Medical Center

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