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Immunology

D-Index
56
Citations
15446
World Ranking
3681
National Ranking
1696

Overview

Ross M. Kedl is affiliated with the University of Colorado Boulder in the United States. Their research primarily spans the fields of Immunology and Microbiology, with substantial contributions also to Medicine. Within these domains, they have focused on Immunology, Infectious Diseases, Oncology, Molecular Biology, and Pulmonary and Respiratory Medicine.

Their work addresses a range of topics including Immune Cell Function and Interaction, T-cell and B-cell Immunology, Immunotherapy and Immune Responses, SARS-CoV-2 and COVID-19 Research, CAR-T cell therapy research, Cancer Immunotherapy and Biomarkers, and IL-33, ST2, and ILC Pathways.

Kedl has contributed to multiple recent papers such as:

  • Elective nodal irradiation mitigates local and systemic immunity generated by combination radiation and immunotherapy in head and neck tumors (2022, Nature Communications)
  • Cytotoxic innate lymphoid cells sense cancer cell-expressed interleukin-15 to suppress human and murine malignancies (2022, Nature Immunology)
  • Simultaneous targeting of PD-1 and IL-2Rβγ with radiation therapy inhibits pancreatic cancer growth and metastasis (2023, Cancer Cell)
  • Chemokine Signatures of Pathogen-Specific T Cells I: Effector T Cells (2020, The Journal of Immunology)
  • B cells promote CD8 T cell primary and memory responses to subunit vaccines (2021, Cell Reports)

Their frequent co-authors include Christopher A. Hunter, Jared Klarquist, David A. Christian, Anthony T. Phan, and Elena W.Y. Hsieh.

Kedl's research has been published extensively in venues such as The Journal of Immunology, bioRxiv (Cold Spring Harbor Laboratory), Nature Immunology, Cell Reports, and Nature Communications.

Best Publications

  • Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude.

    James J. Moon;H. Hamlet Chu;Marion Pepper;Stephen J. McSorley

  • Inflammatory Cytokines Provide a Third Signal for Activation of Naive CD4 + and CD8 + T Cells

    Julie M. Curtsinger;Clint S. Schmidt;Anna Mondino;Debra C. Lins

  • Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8.

    Keith B. Gorden;Kevin S. Gorski;Sheila J. Gibson;Ross M. Kedl

  • T cell responses: naïve to memory and everything in between

    Nathan D. Pennock;Jason T. White;Eric W. Cross;Elizabeth E. Cheney

  • T cells compete for access to antigen-bearing antigen-presenting cells

    Ross M. Kedl;William A. Rees;David A. Hildeman;Brian Schaefer

  • Plasmacytoid dendritic cells produce cytokines and mature in response to the TLR7 agonists, imiquimod and resiquimod

    Sheila J Gibson;Jana M Lindh;Tony R Riter;Raymond M Gleason

  • The antigen-specific CD8+ T cell repertoire in unimmunized mice includes memory phenotype cells bearing markers of homeostatic expansion.

    Catherine Haluszczak;Adovi D. Akue;Sara E. Hamilton;Lisa D.S. Johnson

  • Observation of antigen-dependent CD8+ T-cell/ dendritic cell interactions in vivo.

    Brian C. Schaefer;Michele L. Schaefer;John W. Kappler;John W. Kappler;Philippa Marrack;Philippa Marrack

  • Combined TLR and CD40 Triggering Induces Potent CD8+ T Cell Expansion with Variable Dependence on Type I IFN

    Cory L. Ahonen;Christie L. Doxsee;Sean M. McGurran;Tony R. Riter

  • HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates

    Ulrike Wille-Reece;Barbara J. Flynn;Karin Loré;Richard A. Koup

  • Mechanism of T cell tolerance induction by murine hepatic Kupffer cells.

    Qiang You;Linling Cheng;Ross M. Kedl;Changqing Ju

  • CD103+ pulmonary dendritic cells preferentially acquire and present apoptotic cell–associated antigen

    A. Nicole Desch;Gwendalyn J. Randolph;Kenneth M Murphy;Emmanuel L Gautier

  • Toll-like receptor agonists influence the magnitude and quality of memory T cell responses after prime-boost immunization in nonhuman primates

    Ulrike Wille-Reece;Barbara J. Flynn;Karin Loré;Richard A. Koup

  • An inverse relationship between T cell receptor affinity and antigen dose during CD4(+) T cell responses in vivo and in vitro.

    William Rees;Jeremy Bender;T. Kent Teague;Ross M. Kedl

  • Efficient immunization and cross-priming by vaccine adjuvants containing TLR3 or TLR9 agonists complexed to cationic liposomes.

    Karen Zaks;Michael Jordan;Amanda Guth;Karen Sellins

  • Immunological adjuvants promote activated T cell survival via induction of Bcl-3.

    Thomas C. Mitchell;Thomas C. Mitchell;David Hildeman;Ross M. Kedl;T. Kent Teague;T. Kent Teague

  • T cells down-modulate peptide-MHC complexes on APCs in vivo.

    Ross M Kedl;Brian C Schaefer;John W Kappler;Philippa Marrack

  • Activation changes the spectrum but not the diversity of genes expressed by T cells.

    T. Kent Teague;David Hildeman;Ross M. Kedl;Tom Mitchell

  • Epitope dominance, competition and T cell affinity maturation.

    Ross M Kedl;John W Kappler;Philippa Marrack

  • Polyethylenimine-based siRNA nanocomplexes reprogram tumor-associated dendritic cells via TLR5 to elicit therapeutic antitumor immunity

    Juan R. Cubillos-Ruiz;Xavier Engle;Uciane K. Scarlett;Diana Martinez

  • Mechanism of T Cell Tolerance Induction by Murine Hepatic

    Qiang You;Linling Cheng;Ross M. Kedl;Cynthia Ju

Frequent Co-Authors

Philippa Marrack
Philippa Marrack National Jewish Health
John W. Kappler
John W. Kappler National Jewish Health
Claudia Jakubzick
Claudia Jakubzick Dartmouth College
Christopher A. Hunter
Christopher A. Hunter University of Pennsylvania
Karin Loré
Karin Loré Karolinska Institute
Robert A. Seder
Robert A. Seder National Institute of Allergy and Infectious Diseases
Steven W. Dow
Steven W. Dow Colorado State University
David A. Hildeman
David A. Hildeman Cincinnati Children's Hospital Medical Center
Kenneth M. Murphy
Kenneth M. Murphy Washington University in St. Louis
Peter M. Henson
Peter M. Henson National Jewish Health

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