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Immunology

D-Index
64
Citations
14247
World Ranking
2938
National Ranking
1381

Overview

Matthew F. Mescher is affiliated with the University of Minnesota in the United States. Their research primarily spans the fields of Medicine and Immunology and Microbiology, with specific focus on Oncology and Immunology as subfields of study.

Mescher's work emphasizes topics such as CAR-T cell therapy research, Cancer Immunotherapy and Biomarkers, and Immunotherapy and Immune Responses. These areas reflect an ongoing investigation into cellular therapies and immune system mechanisms relevant to cancer treatment.

Among recent publications, one notable paper is titled "Adoptive T Cell Therapy with IL-12-Preconditioned Low-Avidity T Cells Prevents Exhaustion and Results in Enhanced T Cell Activation, Enhanced Tumor Clearance, and Decreased Risk for Autoimmunity", published in 2020 in The Journal of Immunology. This paper has received citations indicating engagement from the scientific community. The venue The Journal of Immunology is also the most frequent publishing platform for their research.

Frequent coauthors collaborating with Mescher include:

  • Christopher Tucker
  • Jason S. Mitchell
  • Tijana Martinov
  • Brandon J. Burbach
  • Lalit K. Beura

This collaborative network supports work that integrates immunological approaches to cancer therapy and related biomarker studies. The coauthorship with these researchers suggests a multidisciplinary approach combining cellular immunology with translational oncology efforts.

There are no records of book publications or awards listed for Mescher up to this point. The scientist's profile is marked by a clear orientation toward research in immunotherapy with specific attention to therapeutic strategies targeting cancer and immune system regulation.

Best Publications

  • Inflammatory Cytokines Provide a Third Signal for Activation of Naive CD4 + and CD8 + T Cells

    Julie M. Curtsinger;Clint S. Schmidt;Anna Mondino;Debra C. Lins

  • Cutting Edge: Type I IFNs Provide a Third Signal to CD8 T Cells to Stimulate Clonal Expansion and Differentiation

    Julie M. Curtsinger;Javier O. Valenzuela;Pujya Agarwal;Debra Lins

  • Signals required for programming effector and memory development by CD8+ T cells.

    Matthew F. Mescher;Julie M Curtsinger;Pujya Agarwal;Kerry A. Casey

  • Inflammatory Cytokines as a Third Signal for T Cell Activation

    Julie M Curtsinger;Matthew F Mescher

  • Signal 3 Determines Tolerance versus Full Activation of Naive CD8 T Cells: Dissociating Proliferation and Development of Effector Function

    Julie M. Curtsinger;Debra C. Lins;Matthew F. Mescher

  • CD8 T Cell Clonal Expansion and Development of Effector Function Require Prolonged Exposure to Antigen, Costimulation, and Signal 3 Cytokine

    Julie M. Curtsinger;Christopher M. Johnson;Matthew F. Mescher

  • Purification and characterization of a prokaryotic glycoprotein from the cell envelope of Halobacterium salinarium.

    M F Mescher;J L Strominger

  • CTLA-4 blockade reverses CD8+ T cell tolerance to tumor by a CD4+ T cell- and IL-2-dependent mechanism.

    Protul Shrikant;Alexander Khoruts;Matthew F Mescher

  • Programming for CD8 T Cell Memory Development Requires IL-12 or Type I IFN

    Zhengguo Xiao;Kerry A. Casey;Stephen C. Jameson;Julie M. Curtsinger

  • The roles of IL-12 in providing a third signal for clonal expansion of naive CD8 T cells.

    Javier Valenzuela;Clint Schmidt;Clint Schmidt;Matthew F Mescher

  • Gene Regulation and Chromatin Remodeling by IL-12 and Type I IFN in Programming for CD8 T Cell Effector Function and Memory

    Pujya Agarwal;Arvind Raghavan;Sarada L. Nandiwada;Julie M. Curtsinger

  • Cytotoxic T lymphocyte mediated lysis without release of serine esterase.

    Hanne L. Ostergaard;Kevin P. Kane;Matthew F. Mescher;William R. Clark

  • CD8+ memory T cells (CD44high, Ly-6C+) are more sensitive than naive cells to (CD44low, Ly-6C-) to TCR/CD8 signaling in response to antigen.

    Julie M. Curtsinger;Debra C. Lins;Matthew F. Mescher

  • Actin-containing matrix associated with the plasma membrane of murine tumour and lymphoid cells.

    Matthew F. Mescher;Mimi J. L. Jose;Steven P. Balk

  • The Autoimmunity-Associated Gene PTPN22 Potentiates Toll-like Receptor-Driven, Type 1 Interferon-Dependent Immunity

    Yaya Wang;Iftach Shaked;Stephanie M. Stanford;Wenbo Zhou

  • CD8+ T Cells Become Nonresponsive (Anergic) Following Activation in the Presence of Costimulation

    Matthew J. Deeths;Ross M. Kedl;Matthew F. Mescher

  • Alloreactive T cells discriminate among a diverse set of endogenous peptides.

    William R. Heath;Kevin P. Kane;Matthew F. Mescher;Linda A. Sherman

  • Adjuvant Effect of IL-12: Conversion of Peptide Antigen Administration from Tolerizing to Immunizing for CD8+ T Cells In Vivo

    Clint S. Schmidt;Matthew F. Mescher

  • Control of Syngeneic Tumor Growth by Activation of CD8+ T Cells: Efficacy Is Limited by Migration Away from the Site and Induction of Nonresponsiveness

    Protul Shrikant;Matthew F. Mescher

  • Peptide antigen priming of naive, but not memory, CD8 T cells requires a third signal that can be provided by IL-12.

    Clint S. Schmidt;Matthew F. Mescher

Frequent Co-Authors

Steven J. Burakoff
Steven J. Burakoff Icahn School of Medicine at Mount Sinai
Zhengguo Xiao
Zhengguo Xiao University of Science and Technology of China
Linda A. Sherman
Linda A. Sherman Scripps Research Institute
Steven P. Balk
Steven P. Balk Beth Israel Deaconess Medical Center
Jaime F. Modiano
Jaime F. Modiano University of Minnesota
Yoji Shimizu
Yoji Shimizu University of Minnesota
Jack L. Strominger
Jack L. Strominger Harvard University
Stephen C. Jameson
Stephen C. Jameson University of Minnesota
Protul Shrikant
Protul Shrikant Mayo Clinic
Baruj Benacerraf
Baruj Benacerraf Harvard University

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