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Biology and Biochemistry

D-Index
66
Citations
17535
World Ranking
8578
National Ranking
3854

Overview

Yoji Shimizu is affiliated with the University of Minnesota in the United States. Their research primarily spans the fields of Medicine and Immunology and Microbiology, with a focus on subfields including Immunology, Oncology, Hematology, Psychiatry and Mental Health, and Molecular Biology.

The scientist's work covers various topics related to immune system function and cancer treatment, including Cancer Immunotherapy and Biomarkers, Immunotherapy and Immune Responses, Immune Cell Function and Interaction, T-cell and B-cell Immunology, Hematopoietic Stem Cell Transplantation, Cancer, Stress, Anesthesia, and Immune Response, as well as vaccines and immunoinformatics approaches.

Yoji Shimizu has contributed to several publications, including the following recent papers:

  • Irreversible electroporation augments checkpoint immunotherapy in prostate cancer and promotes tumor antigen-specific tissue-resident memory CD8+ T cells, 2021, Nature Communications
  • Notch signaling drives intestinal graft-versus-host disease in mice and nonhuman primates, 2023, Science Translational Medicine
  • Faculty Opinions recommendation of MHC-II neoantigens shape tumour immunity and response to immunotherapy., 2020, Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • Faculty Opinions recommendation of Tissue-resident memory CD8+ T cells amplify anti-tumor immunity by triggering antigen spreading through dendritic cells., 2020, Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • Evolutionarily conserved effects of Notch signaling drive intestinal graft-versus-host disease in mice and non-human primates, 2022, bioRxiv (Cold Spring Harbor Laboratory)

Frequent publication venues for Shimizu include:

  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • Nature Communications
  • Science Translational Medicine
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Zen Nihon Shinkyu Gakkai zasshi (Journal of the Japan Society of Acupuncture and Moxibustion)

Collaborators frequently working with Shimizu include:

  • Brandon J. Burbach
  • Stephen O'Flanagan
  • Qi Shao
  • Samira M. Azarin
  • Victor Tkachev

The scientist's research is centered on immune mechanisms relevant to cancer therapy and transplantation medicine, particularly focusing on T-cell immunity and the modulation of immune responses in disease contexts.

Best Publications

  • The LFA-1 ligand ICAM-1 provides an important costimulatory signal for T cell receptor-mediated activation of resting T cells.

    G A Van Seventer;Y Shimizu;K J Horgan;S Shaw

  • Lymphocyte interactions with endothelial cells.

    Yoji Shimizu;Walter Newman;Yoshiya Tanaka;Stephen Shaw

  • Regulated expression and binding of three VLA (β1) integrin receptors on T cells

    Yoji Shimizu;Gijs A. Van Seventer;Kevin J. Horgan;Stephen Shaw

  • Activation-independent binding of human memory T cells to adhesion molecule ELAM-1

    Yoji Shimizu;Stephen Shaw;Norma Graber;T. Venkat Gopal

  • Costimulation of proliferative responses of resting CD4+ T cells by the interaction of VLA-4 and VLA-5 with fibronectin or VLA-6 with laminin.

    Y Shimizu;G A van Seventer;K J Horgan;S Shaw

  • CD31 expressed on distinctive T cell subsets is a preferential amplifier of beta 1 integrin-mediated adhesion.

    Y Tanaka;S M Albelda;K J Horgan;G A van Seventer

  • Four molecular pathways of T cell adhesion to endothelial cells: Roles of LFA-1, VCAM-1, and ELAM-1 and changes in pathway hierarchy under different activation conditions

    Y Shimizu;W Newman;T V Gopal;K J Horgan

  • Roles of adhesion molecules in T-cell recognition: fundamental similarities between four integrins on resting human T cells (LFA-1, VLA-4, VLA-5, VLA-6) in expression, binding, and costimulation.

    Yoji Shimizu;Gijs A. Van Seventer;Kevin J. Horgan;Stephen Shaw

  • Lymphocyte interactions with extracellular matrix.

    Yoji Shimizu;Stephen Shaw

  • Analysis of T cell stimulation by superantigen plus major histocompatibility complex class II molecules or by CD3 monoclonal antibody: costimulation by purified adhesion ligands VCAM-1, ICAM-1, but not ELAM-1.

    G A van Seventer;W Newman;Y Shimizu;T B Nutman

  • Dual role of the CD44 molecule in T cell adhesion and activation.

    Y Shimizu;G A Van Seventer;R Siraganian;L Wahl

  • Coupling of the TCR to integrin activation by Slap-130/Fyb.

    Erik J. Peterson;Melody L. Woods;Sally A. Dmowski;Geo Derimanov

  • Adhesion through the LFA-1 (CD11a/CD18)-ICAM-1 (CD54) and the VLA-4 (CD49d)-VCAM-1 (CD106) pathways prevents apoptosis of germinal center B cells.

    G. Koopman;R. M. J. Keehnen;E. Lindhout;W. Newman

  • Production of human cells expressing individual transferred HLA-A,-B,-C genes using an HLA-A,-B,-C null human cell line.

    Y Shimizu;R DeMars

  • Natural killer (NK) cells as a responder to interleukin 2 (IL 2). II. IL 2-induced interferon gamma production.

    K Handa;R Suzuki;H Matsui;Y Shimizu

  • β-Actin specifically controls cell growth, migration, and the G-actin pool

    Tina M. Bunnell;Brandon J. Burbach;Yoji Shimizu;James M. Ervasti

  • LFA-3, CD44, and CD45: physiologic triggers of human monocyte TNF and IL-1 release.

    D S A Webb;Y Shimizu;G A Van Seventer;S Shaw

  • Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse.

    Timothy S. Gomez;Karan Kumar;Ricardo B. Medeiros;Yoji Shimizu

  • HLA-E. A novel HLA class I gene expressed in resting T lymphocytes.

    B H Koller;D E Geraghty;Y Shimizu;R DeMars

  • Integrins and T Cell–Mediated Immunity

    Jonathan T. Pribila;Angie C. Quale;Kristen L. Mueller;Yoji Shimizu

Frequent Co-Authors

Stephen Shaw
Stephen Shaw National Institutes of Health
Robert DeMars
Robert DeMars University of Wisconsin–Madison
Brian J. Nickoloff
Brian J. Nickoloff Loyola University Chicago
Laurence A. Turka
Laurence A. Turka Harvard University
Matthew F. Mescher
Matthew F. Mescher University of Minnesota
Yoshiya Tanaka
Yoshiya Tanaka University of Occupational and Environmental Health Japan
Beverly H. Koller
Beverly H. Koller University of North Carolina at Chapel Hill
Craig B. Thompson
Craig B. Thompson Memorial Sloan Kettering Cancer Center
Harry T. Orr
Harry T. Orr University of Minnesota

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