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Neuroscience

D-Index
76
Citations
22899
World Ranking
1904
National Ranking
913

Research.com Recognitions

  • 2009 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1993 - Fellow of Alfred P. Sloan Foundation

Overview

David J. Linden is affiliated with Johns Hopkins University School of Medicine in the United States. Their research spans multiple areas within neuroscience and molecular biology, focusing on topics such as nerve injury and regeneration, neuroendocrine regulation and behavior, receptor mechanisms and signaling, and neuroscience and neuropharmacology research.

The scientist has contributed to studies in the following areas:

  • Nerve injury and regeneration
  • Neuroendocrine regulation and behavior
  • Receptor Mechanisms and Signaling
  • Neuroscience and Neuropharmacology Research
  • Neurotransmitter Receptor Influence on Behavior
  • PI3K/AKT/mTOR signaling in cancer
  • Phosphodiesterase function and regulation

Their publication record covers a range of journals and venues:

  • eNeuro
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Biological Psychiatry
  • Neuron
  • European Neuropsychopharmacology

They have published several recent papers, including:

  • "Persistently Elevated mTOR Complex 1-S6 Kinase 1 Disrupts DARPP-32-Dependent D1 Dopamine Receptor Signaling and Behaviors," 2020, Biological Psychiatry
  • "The Lateral Habenula Is Necessary for Maternal Behavior in the Naturally Parturient Primiparous Mouse Dam," 2024, eNeuro
  • "Chronic Treatment with Serotonin Selective Reuptake Inhibitors Does Not Affect Regrowth of Serotonin Axons Following Amphetamine Injury in the Mouse Forebrain," 2024, eNeuro
  • "A life in science, ending soon," 2022, Neuron
  • "The lateral habenula is required for maternal behavior in the mouse dam," 2024, bioRxiv (Cold Spring Harbor Laboratory)

Frequent collaborators in their work include Jessie Benedict, Robert H. Cudmore, Diarra Oden, Aleah Spruell, and Patrick Cooke.

Their main fields of study are grouped under Neuroscience and Biochemistry, Genetics and Molecular Biology, with subfields including Cellular and Molecular Neuroscience, Molecular Biology, Social Psychology, Genetics, and Neurology.

Awards received include election as a Fellow of the American Association for the Advancement of Science (AAAS) in 2009, and as a Fellow of the Alfred P. Sloan Foundation in 1993.

Best Publications

  • d-Serine is an endogenous ligand for the glycine site of the N-methyl-d-aspartate receptor

    Jean Pierre Mothet;Angèle T. Parent;Angèle T. Parent;Herman Wolosker;Roscoe O. Brady

  • The other side of the engram: experience-driven changes in neuronal intrinsic excitability.

    Wei Zhang;David J. Linden

  • Homer Binds a Novel Proline-Rich Motif and Links Group 1 Metabotropic Glutamate Receptors with IP3 Receptors

    Jian Cheng Tu;Bo Xiao;Joseph P. Yuan;Anthony A. Lanahan

  • Translocation of protein kinase C activity may mediate hippocampal long-term potentiation.

    Raymond F. Akers;David M. Lovinger;Patricia A. Colley;David J. Linden

  • Beyond parallel fiber LTD: the diversity of synaptic and non-synaptic plasticity in the cerebellum.

    Christian Hansel;David J. Linden;Egidio D'Angelo;Egidio D'Angelo

  • Neurodegeneration in Lurcher mice caused by mutation in δ2 glutamate receptor gene

    Jian Zuo;Philip L. De Jager;Kanji A. Takahashi;Weining Jiang

  • Elongation Factor 2 and Fragile X Mental Retardation Protein Control the Dynamic Translation of Arc/Arg3.1 Essential for mGluR-LTD

    Sungjin Park;Joo Min Park;Sangmok Kim;Jin Ah Kim

  • Expression of Cerebellar Long-Term Depression Requires Postsynaptic Clathrin-Mediated Endocytosis

    Yu Tian Wang;David J. Linden

  • Long-term synaptic depression in the mammalian brain

    David J. Linden

  • LONG-TERM SYNAPTIC DEPRESSION

    David J. Linden;John A. Connor

  • A long-term depression of AMPA currents in cultured cerebellar Purkinje neurons.

    David J. Linden;Michael H. Dickinson;Michelle Smeyne;John A. Connor

  • Cerebellar long-term depression requires PKC-regulated interactions between GluR2/3 and PDZ domain-containing proteins.

    Jun Xia;Hee Jung Chung;Cornelia Wihler;Richard L Huganir

  • Expression of a Protein Kinase C Inhibitor in Purkinje Cells Blocks Cerebellar LTD and Adaptation of the Vestibulo-Ocular Reflex

    Chris I. De Zeeuw;Christian Hansel;Feng Bian;Sebastiaan K.E. Koekkoek

  • Participation of postsynaptic PKC in cerebellar long-term depression in culture.

    David J. Linden;John A. Connor

  • Activation of the TRPC1 cation channel by metabotropic glutamate receptor mGluR1.

    Sang Jeong Kim;Sang Jeong Kim;Yu Shin Kim;Joseph P. Yuan;Ronald S. Petralia

  • Requirement of AMPA Receptor GluR2 Phosphorylation for Cerebellar Long-Term Depression

    Hee Jung Chung;Jordan P. Steinberg;Richard L. Huganir;David J. Linden

  • The role of protein kinase C in long-term potentiation: a testable model

    David J. Linden;Aryeh Routtenberg

  • Regulation of the rebound depolarization and spontaneous firing patterns of deep nuclear neurons in slices of rat cerebellum.

    Carlos D. Aizenman;David J. Linden

  • Narp regulates homeostatic scaling of excitatory synapses on parvalbumin-expressing interneurons.

    Michael C Chang;Joo Min Park;Kenneth A Pelkey;Heidi L Grabenstatter

  • Reevaluating the Role of LTD in Cerebellar Motor Learning

    Martijn Schonewille;Zhenyu Gao;Henk Jan Boele;Maria F. Vinueza Veloz

  • Targeted In Vivo Mutations of the AMPA Receptor Subunit GluR2 and Its Interacting Protein PICK1 Eliminate Cerebellar Long-Term Depression

    Jordan P. Steinberg;Kogo Takamiya;Ying Shen;Jun Xia

Frequent Co-Authors

Richard L. Huganir
Richard L. Huganir Johns Hopkins University School of Medicine
Paul F. Worley
Paul F. Worley Johns Hopkins University School of Medicine
Aryeh Routtenberg
Aryeh Routtenberg Northwestern University
Christian Hansel
Christian Hansel University of Chicago
Chris I. De Zeeuw
Chris I. De Zeeuw Erasmus University Rotterdam
John A. Connor
John A. Connor University of New Mexico
Mikhail V. Pletnikov
Mikhail V. Pletnikov Johns Hopkins University
Ronald S. Petralia
Ronald S. Petralia National Institutes of Health
David D. Ginty
David D. Ginty Howard Hughes Medical Institute
Alena Savonenko
Alena Savonenko Johns Hopkins University School of Medicine

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