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Neuroscience

D-Index
38
Citations
7128
World Ranking
8503
National Ranking
3623

Overview

Alena Savonenko is affiliated with Johns Hopkins University School of Medicine in the United States. Their research spans multiple disciplines within medicine and neuroscience, focusing particularly on neurodegenerative diseases and cognitive impairments.

The primary fields of study for Savonenko include Medicine, Neuroscience, and Biochemistry, Genetics and Molecular Biology. Their work is further specialized within subfields such as Physiology, Molecular Biology, Cognitive Neuroscience, Genetics, and Psychiatry and Mental Health.

The main topics covered by Savonenko's research reflect a focus on neurodegenerative and neurodevelopmental disorders. These topics include Alzheimer's disease research and treatments, dementia and cognitive impairment research, genetics and neurodevelopmental disorders, functional brain connectivity studies, tryptophan and brain disorders, memory and neural mechanisms, and phosphodiesterase function and regulation.

Co-authors who frequently collaborate with Savonenko are Paul F. Worley, Gwenn S. Smith, Hiroto Kuwabara, Michael A. Kraut, and Neda F Gould, each having co-authored six publications.

Publication venues where Savonenko's work has appeared most often include Biological Psychiatry, Neurobiology of Aging, and bioRxiv (Cold Spring Harbor Laboratory) with two publications each. Other frequent publication venues are eLife and Science Advances.

Recent papers authored or co-authored by Alena Savonenko include:

  • A non-mosaic transchromosomic mouse model of Down syndrome carrying the long arm of human chromosome 21 (2020), published in eLife
  • A biomarker-authenticated model of schizophrenia implicating NPTX2 loss of function (2021), published in Science Advances
  • Positron emission tomography imaging of serotonin degeneration and beta-amyloid deposition in late-life depression evaluated with multi-modal partial least squares (2021), published in Translational Psychiatry
  • Regional amyloid correlates of cognitive performance in ageing and mild cognitive impairment (2022), published in Brain Communications
  • Serotonin Degeneration and Amyloid-β Deposition in Mild Cognitive Impairment: Relationship to Cognitive Deficits (2023), published in Journal of Alzheimer s Disease

Best Publications

  • BACE1, a Major Determinant of Selective Vulnerability of the Brain to Amyloid-β Amyloidogenesis, is Essential for Cognitive, Emotional, and Synaptic Functions

    Fiona M. Laird;Huaibin Cai;Alena V. Savonenko;Mohamed H. Farah

  • Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease.

    Joanna L. Jankowsky;Joanna L. Jankowsky;Tatiana Melnikova;Daniel J. Fadale;Guilian M. Xu

  • Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: Relationships to β-amyloid deposition and neurotransmitter abnormalities

    Alena Savonenko;Guilian M. Xu;Tatiana Melnikova;Johanna L. Morton

  • Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice

    A. V. Savonenko;T. Melnikova;F. M. Laird;K.-A. Stewart

  • NPTX2 and cognitive dysfunction in Alzheimer’s Disease

    Mei Fang Xiao;Desheng Xu;Michael T. Craig;Kenneth A. Pelkey

  • Persistent Amyloidosis following Suppression of Aβ Production in a Transgenic Model of Alzheimer Disease

    Joanna L Jankowsky;Joanna L Jankowsky;Hilda H Slunt;Hilda H Slunt;Victoria Gonzales;Alena V Savonenko

  • A Mouse Model of Blast Injury to Brain: Initial Pathological, Neuropathological, and Behavioral Characterization

    Vassilis E. Koliatsos;Ibolja Cernak;Leyan Xu;Yeajin Song

  • Age-dependent cognitive deficits and neuronal apoptosis in cyclooxygenase-2 transgenic mice

    Katrin I. Andreasson;Alena Savonenko;Sveta Vidensky;Joseph J. Goellner

  • Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease.

    Ying Liu;Mi Jeong Yoo;Alena Savonenko;Wanda Stirling

  • Effectiveness of Estrogen Replacement in Restoration of Cognitive Function after Long-Term Estrogen Withdrawal in Aging Rats

    Alicja L. Markowska;Alena V. Savonenko

  • Morphometry of the human substantia nigra in ageing and Parkinson's disease.

    Richard O’Brien;Alena V. Savonenko;Susan M. Resnick

  • PET imaging of microglia by targeting macrophage colony-stimulating factor 1 receptor (CSF1R).

    Andrew G. Horti;Ravi Naik;Catherine A. Foss;Il Minn

  • The cognitive effects of ovariectomy and estrogen replacement are modulated by aging

    A.V Savonenko;A.L Markowska

  • Retraction Notice to: Enhanced Polyubiquitination of Shank3 and NMDA Receptor in a Mouse Model of Autism

    M. Ali Ali Bangash;Joo Min Park;Tatiana Melnikova;Dehua Wang

  • Cycloxygenase-2 activity promotes cognitive deficits but not increased amyloid burden in a model of Alzheimer's disease in a sex-dimorphic pattern.

    T. Melnikova;A. Savonenko;Q. Wang;X. Liang

  • Synthesis and biodistribution of [11C]A-836339, a new potential radioligand for PET imaging of cannabinoid type 2 receptors (CB2)

    Andrew Horti;Yongjun Gao;Hayden T. Ravert;Paige Finley

  • Nuclear-targeting of mutant huntingtin fragments produces Huntington's disease-like phenotypes in transgenic mice

    Gabriele Schilling;Alena V. Savonenko;Alexandra Klevytska;Johanna L. Morton

  • Normal cognitive behavior in two distinct congenic lines of transgenic mice hyperexpressing mutant APPSWE

    Alena V Savonenko;Guilian M Xu;Donald L Price;David R Borchelt

  • Cannabinoid CB2 Receptors in a Mouse Model of Aβ Amyloidosis: Immunohistochemical Analysis and Suitability as a PET Biomarker of Neuroinflammation.

    Alena V. Savonenko;Tatiana Melnikova;Yuchuan Wang;Hayden Ravert

  • Environmental, pharmacological, and genetic modulation of the HD phenotype in transgenic mice

    Gabriele Schilling;Alena V. Savonenko;Michael L. Coonfield;Johanna L. Morton

  • Molecular imaging of serotonin degeneration in mild cognitive impairment.

    Gwenn S. Smith;Frederick S. Barrett;Jin Hui Joo;Najlla Nassery

Frequent Co-Authors

Paul F. Worley
Paul F. Worley Johns Hopkins University School of Medicine
Alicja L. Markowska
Alicja L. Markowska National Institute on Aging
Roger H. Reeves
Roger H. Reeves Johns Hopkins University School of Medicine
Michael A. Kraut
Michael A. Kraut Johns Hopkins University School of Medicine
Mitsuo Oshimura
Mitsuo Oshimura Tottori University
David J. Linden
David J. Linden Johns Hopkins University School of Medicine
Katrin Andreasson
Katrin Andreasson Stanford University
Kenneth A. Pelkey
Kenneth A. Pelkey National Institutes of Health
Huaibin Cai
Huaibin Cai National Institutes of Health
Susan M. Resnick
Susan M. Resnick National Institutes of Health

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