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Neuroscience

D-Index
58
Citations
9755
World Ranking
4234
National Ranking
1910

Overview

Fred J. Helmstetter is affiliated with the University of Wisconsin-Milwaukee in the United States. Their research primarily spans the fields of Neuroscience and Biochemistry, Genetics and Molecular Biology, with a notable focus on Cellular and Molecular Neuroscience, Cognitive Neuroscience, Molecular Biology, Behavioral Neuroscience, and Genetics.

The scientist's work extensively covers topics related to Memory and Neural Mechanisms, Neuroscience and Neuropharmacology Research, Stress Responses and Cortisol, Genetics and Neurodevelopmental Disorders, Ubiquitin and Proteasome Pathways, Neuroendocrine Regulation and Behavior, and Receptor Mechanisms and Signaling.

Frequent collaborators include Sydney Trask, Nicole C. Ferrara, Shane E. Pullins, Brooke N. Dulka, and David S. Reis.

Helmstetter's recent published papers demonstrate a focus on memory encoding, fear discrimination learning, and the molecular mechanisms underlying memory and aging in various brain regions. Selected recent papers include:

  • The anterior retrosplenial cortex encodes event-related information and the posterior retrosplenial cortex encodes context-related information during memory formation, 2021, Neuropsychopharmacology
  • Decreased cued fear discrimination learning in female rats as a function of estrous phase, 2020, Learning & Memory
  • Age-Related Memory Impairment and Sex-Specific Alterations in Phosphorylation of the Rpt6 Proteasome Subunit and Polyubiquitination in the Basolateral Amygdala and Medial Prefrontal Cortex, 2021, Frontiers in Aging Neuroscience
  • Optogenetic inhibition of either the anterior or posterior retrosplenial cortex disrupts retrieval of a trace, but not delay, fear memory, 2021, Neurobiology of Learning and Memory
  • Unique roles for the anterior and posterior retrosplenial cortices in encoding and retrieval of memory for context, 2022, Cerebral Cortex

Helmstetter's publications appear frequently in journals such as Neurobiology of Learning and Memory, Learning & Memory, International Journal of Molecular Sciences, Neuropsychopharmacology, and Frontiers in Aging Neuroscience.

Best Publications

  • Neural substrates mediating human delay and trace fear conditioning

    David C. Knight;Dominic T. Cheng;Christine N. Smith;Elliot A. Stein;Elliot A. Stein

  • Effects of muscimol applied to the basolateral amygdala on acquisition and expression of contextual fear conditioning in rats.

    Fred J. Helmstetter;Patrick S. Bellgowan

  • Amygdala and hippocampal activity during acquisition and extinction of human fear conditioning

    David C. Knight;David C. Knight;Christine N. Smith;Christine N. Smith;Dominic T. Cheng;Elliot A. Stein;Elliot A. Stein

  • Translational control via the mammalian target of rapamycin pathway is critical for the formation and stability of long-term fear memory in amygdala neurons.

    Ryan G. Parsons;Georgette M. Gafford;Fred J. Helmstetter

  • The amygdala is essential for the expression of conditional hypoalgesia.

    Fred J. Helmstetter

  • Conditional analgesia, defensive freezing, and benzodiazepines.

    Michael S. Fanselow;Fred J. Helmstetter

  • Trace and contextual fear conditioning require neural activity and NMDA receptor-dependent transmission in the medial prefrontal cortex

    Marieke R. Gilmartin;Fred J. Helmstetter

  • Functional MRI of human amygdala activity during Pavlovian fear conditioning: Stimulus processing versus response expression

    Dominic T. Cheng;David C. Knight;David C. Knight;Christine N. Smith;Elliot A. Stein

  • Prefrontal cortical regulation of fear learning.

    Marieke R. Gilmartin;Marieke R. Gilmartin;Nicholas L. Balderston;Fred J. Helmstetter

  • Chronic stress selectively reduces hippocampal volume in rats: a longitudinal magnetic resonance imaging study.

    Taekwan Lee;Tim Jarome;Shi Jiang Li;Jeansok J. Kim

  • Acquisition of fear conditioning in rats requires the synthesis of mRNA in the amygdala.

    David J. Bailey;Jeansok J. Kim;William Sun;Richard F. Thompson

  • Activity Dependent Protein Degradation Is Critical for the Formation and Stability of Fear Memory in the Amygdala

    Timothy J. Jarome;Craig T. Werner;Janine L. Kwapis;Fred J. Helmstetter

  • Antinociception following opioid stimulation of the basolateral amygdala is expressed through the periaqueductal gray and rostral ventromedial medulla

    Fred J Helmstetter;Sheralee A Tershner;Laura H Poore;Patrick S.F Bellgowan

  • Human amygdala activity during the expression of fear responses.

    Dominic T. Cheng;David C. Knight;Christine N. Smith;Fred J. Helmstetter

  • Lesions of the amygdala block conditional hypoalgesia on the tail flick test.

    Fred J. Helmstetter;Patrick S. Bellgowan

  • Contribution of the amygdala to learning and performance of conditional fear.

    Fred J. Helmstetter

  • The ubiquitin-proteasome system as a critical regulator of synaptic plasticity and long-term memory formation.

    Timothy J. Jarome;Fred J. Helmstetter

  • Time-Dependent Expression of Arc and Zif268 after Acquisition of Fear Conditioning

    Mary E. Lonergan;Georgette M. Gafford;Timothy J. Jarome;Fred J. Helmstetter

  • Stress-induced hypoalgesia and defensive freezing are attenuated by application of diazepam to the amygdala.

    Fred J. Helmstetter

  • Functional MRI of human amygdala activity during Pavlovian fear conditioning: stimulus processing versus response expression.

    Unknown

  • Lesions of the periaqueductal gray and rostral ventromedial medulla disrupt antinociceptive but not cardiovascular aversive conditional responses

    Fred J. Helmstetter;Sheralee A. Tershner

Frequent Co-Authors

Michael S. Fanselow
Michael S. Fanselow University of California, Los Angeles
Patrick S.F. Bellgowan
Patrick S.F. Bellgowan National Institutes of Health
Elliot A. Stein
Elliot A. Stein National Institute on Drug Abuse
Christine L. Larson
Christine L. Larson University of Wisconsin–Milwaukee
Sylvain Baillet
Sylvain Baillet McGill University
Jeansok J. Kim
Jeansok J. Kim University of Washington
Brady A. Riedner
Brady A. Riedner University of Wisconsin–Madison
Jonathan D. Wallis
Jonathan D. Wallis University of California, Berkeley
Francisco Gonzalez-Lima
Francisco Gonzalez-Lima The University of Texas at Austin

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