World's Best Scientists 2026 revealed!
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Best Scientists
2025
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Biology and Biochemistry
USA
2026

D-Index & Metrics

Best Scientists

D-Index
284
Citations
292625
World Ranking
21
National Ranking
15

Neuroscience

D-Index
286
Citations
293045
World Ranking
2
National Ranking
2

Biology and Biochemistry

D-Index
283
Citations
285393
World Ranking
2
National Ranking
1

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United States Leader Award
  • 2026 - Research.com Neuroscience in United States Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Biology and Biochemistry in United States Leader Award
  • 2025 - Research.com Neuroscience in United States Leader Award
  • 2023 - Research.com Biology and Biochemistry in United States Leader Award
  • 2023 - Research.com Medicine in United States Leader Award
  • 2022 - Research.com Biology and Biochemistry in United States Leader Award
  • 2014 - Warren Alpert Foundation Prize For seminal contributions to our understanding of neurotransmission and neurodegeneration.
  • 2013 - NAS Award in the Neurosciences, U.S. National Academy of Sciences For the elucidation of fundamental mechanisms of chemical signaling, including opiate receptors, NO signaling, and other neurotransmitter/receptor interactions.
  • 2012 - Fellow, National Academy of Inventors
  • 2007 - Albany Medical Center Prize in Medicine and Biomedical Research
  • 2006 - Perl-UNC Prize, University of North Carolina at Chapel Hill Identification of Opiate Receptors in the Brain.
  • 2003 - US President's National Medal of Science "For his major contributions to the understanding of neurotransmitters, their receptors in the nervous system, mechanisms of action of psychoactive drugs, and pathways of signal transduction in the brain.", Presented by President George W. Bush in a White House East Room ceremony on March 14, 2005.
  • 2001 - Rhoda and Bernard Sarnat International Prize in Mental Health, National Academy of Medicine
  • 2000 - Ralph W. Gerard Prize in Neuroscience, Society for Neuroscience
  • 1990 - Robert J. and Claire Pasarow Foundation Medical Research Award
  • 1988 - Member of the National Academy of Medicine (NAM)
  • 1985 - AMA Scientific Achievement Award, American Medical Association
  • 1982 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1980 - Member of the National Academy of Sciences
  • 1979 - Fellow of the American Academy of Arts and Sciences
  • 1978 - Albert Lasker Award for Basic Medical Research, Lasker Foundation

Overview

Solomon H. Snyder is affiliated with Johns Hopkins University School of Medicine in the United States and has made extensive contributions to the fields of biochemistry, genetics, molecular biology, and medicine. Their research spans various subfields including molecular biology, biochemistry, physiology, cellular and molecular neuroscience, and cell biology.

The main topics covered in their scientific work include:

  • Amino Acid Enzymes and Metabolism
  • Epigenetics and DNA Methylation
  • Heme Oxygenase-1 and Carbon Monoxide
  • Mitochondrial Function and Pathology
  • Autophagy in Disease and Therapy
  • Neurotransmitter Receptor Influence on Behavior
  • Neuroinflammation and Neurodegeneration Mechanisms

Their frequent collaborators include Bindu D. Paul, Evan R. Semenza, Chirag Vasavda, Adele M. Snowman, and Adarsha P. Malla.

Solomon H. Snyder's recent publications include the following papers:

  • "Signaling by cGAS-STING in Neurodegeneration, Neuroinflammation, and Aging," 2020, published in Trends in Neurosciences
  • "Redox imbalance links COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome," 2021, published in Proceedings of the National Academy of Sciences
  • "Effects of hydrogen sulfide on mitochondrial function and cellular bioenergetics," 2020, published in Redox Biology
  • "Hydrogen sulfide is neuroprotective in Alzheimer's disease by sulfhydrating GSK3β and inhibiting Tau hyperphosphorylation," 2021, published in Proceedings of the National Academy of Sciences
  • "D-cysteine is an endogenous regulator of neural progenitor cell dynamics in the mammalian brain," 2021, published in Proceedings of the National Academy of Sciences

The most frequent venues for their publications are:

  • Proceedings of the National Academy of Sciences
  • bioRxiv (Cold Spring Harbor Laboratory)
  • The FASEB Journal
  • Science Advances
  • iScience

Among various recognitions, Solomon H. Snyder has received multiple awards over the years, including:

  • Warren Alpert Foundation Prize, 2014, for seminal contributions to understanding neurotransmission and neurodegeneration
  • NAS Award in the Neurosciences from the U.S. National Academy of Sciences, 2013, for elucidation of fundamental mechanisms of chemical signaling
  • Fellow of the National Academy of Inventors, 2012
  • Albany Medical Center Prize in Medicine and Biomedical Research, 2007
  • Perl-UNC Prize for identification of opiate receptors in the brain, 2006
  • US President's National Medal of Science, 2003, awarded for major contributions to understanding neurotransmitters, receptors, psychoactive drug mechanisms, and brain signal transduction
  • Rhoda and Bernard Sarnat International Prize in Mental Health from the National Academy of Medicine, 2001
  • Ralph W. Gerard Prize in Neuroscience from the Society for Neuroscience, 2000
  • Robert J. and Claire Pasarow Foundation Medical Research Award, 1990
  • Member of the National Academy of Medicine, 1988
  • AMA Scientific Achievement Award from the American Medical Association, 1985
  • Fellow of the American Association for the Advancement of Science (AAAS), 1982
  • Member of the National Academy of Sciences, 1980
  • Fellow of the American Academy of Arts and Sciences, 1979
  • Albert Lasker Award for Basic Medical Research, 1978

Best Publications

  • Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

    David S. Bredt;Solomon H. Snyder

  • Handbook of psychopharmacology

    Leslie L. Iversen;Susan D. Iversen;Solomon H. Snyder

  • Localization of nitric oxide synthase indicating a neural role for nitric oxide

    David S. Bredt;Paul M. Hwang;Solomon H. Snyder

  • Opiate Receptor: Demonstration in Nervous Tissue

    Candace B. Pert;Solomon H. Snyder

  • Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase.

    David S. Bredt;Paul M. Hwang;Charles E. Glatt;Charles Lowenstein

  • Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs.

    I Creese;D R Burt;S H Snyder

  • Nitric oxide: a physiologic messenger molecule.

    D. S. Bredt;Solomon H Snyder

  • Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

    Valina L. Dawson;Ted M. Dawson;Edythe D. London;David S. Bredt

  • H2S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine γ-Lyase

    Guangdong Yang;Guangdong Yang;Lingyun Wu;Bo Jiang;Wei Yang

  • Nitric oxide, a novel neuronal messenger.

    David S. Bredt;Solomon H. Snyder

  • Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues.

    Ted M. Dawson;David S. Bredt;Majid Fotuhi;Paul M. Hwang

  • Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum

    David S. Bredt;Solomon H. Snyder

  • Carbon monoxide: a putative neural messenger.

    Ajay Verma;David J. Hirsch;Charles E. Glatt;Gabriele V. Ronnett

  • RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs.

    David M. Sabatini;Hediye Erdjument-Bromage;Mary Lui;Paul Tempst

  • Multiple Serotonin Receptors: Differential Binding of [3H]5-Hydroxytryptamine, [3H]Lysergic Acid Diethylamide and [3H]Spiroperidol

    Stephen J. Peroutka;Solomon H. Snyder

  • Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity.

    Jonathan A. Javitch;Robert J. D'Amato;Stephen M. Strittmatter;Solomon H. Snyder

  • Protein S-nitrosylation: a physiological signal for neuronal nitric oxide.

    Samie R. Jaffrey;Hediye Erdjument-Bromage;Christopher D. Ferris;Paul Tempst

  • Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase

    David S. Bredt;Charles E. Glatt;Paul M. Hwang;Majid Fotuhi

  • Muscarinic Cholinergic Binding in Rat Brain

    Henry I. Yamamura;Solomon H. Snyder

  • Antischizophrenic drugs: chronic treatment elevates dopamine receptor binding in brain

    David R. Burt;I. A.N. Creese;Solomon H. Snyder

  • Targeted disruption of the neuronal nitric oxide synthase gene

    Paul L. Huang;Ted M. Dawson;David S. Bredt;Solomon H. Snyder

Frequent Co-Authors

Ted M. Dawson
Ted M. Dawson Johns Hopkins University School of Medicine
David S. Bredt
David S. Bredt Johnson & Johnson (United States)
Michael J. Kuhar
Michael J. Kuhar Emory University
Akira Sawa
Akira Sawa Johns Hopkins University
Seth Blackshaw
Seth Blackshaw Johns Hopkins University School of Medicine
Christopher A. Ross
Christopher A. Ross Johns Hopkins University School of Medicine
Valina L. Dawson
Valina L. Dawson Johns Hopkins University School of Medicine
Julius Axelrod
Julius Axelrod National Institutes of Health
Leslie L. Iversen
Leslie L. Iversen University of Oxford

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