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Neuroscience
USA
2026

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Neuroscience

D-Index
143
Citations
89088
World Ranking
182
National Ranking
118

Medicine

D-Index
143
Citations
89225
World Ranking
1490
National Ranking
866

Research.com Recognitions

  • 2026 - Research.com Neuroscience in United States Leader Award
  • 2025 - Research.com Neuroscience in United States Leader Award
  • 2017 - Rhoda and Bernard Sarnat International Prize in Mental Health, National Academy of Medicine
  • 2012 - Fellow, National Academy of Inventors
  • 2004 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1996 - Robert J. and Claire Pasarow Foundation Medical Research Award
  • 1994 - Fellow of the American Academy of Arts and Sciences
  • 1990 - Member of the National Academy of Medicine (NAM)

Overview

Joseph T. Coyle is affiliated with Harvard University in the United States. Their research spans several areas within neuroscience, biochemistry, genetics, and molecular biology, focusing particularly on cellular and molecular neuroscience, molecular biology, and biological psychiatry.

Their main research topics include:

  • Neuroscience and Neuropharmacology Research
  • Amino Acid Enzymes and Metabolism
  • Tryptophan and Brain Disorders
  • Epigenetics and DNA Methylation
  • Receptor Mechanisms and Signaling
  • Genetics and Neurodevelopmental Disorders
  • Neurotransmitter Receptor Influence on Behavior

Joseph T. Coyle has contributed several papers, with notable recent publications such as:

  • "Activated microglia cause metabolic disruptions in developmental cortical interneurons that persist in interneurons from individuals with schizophrenia," 2020, Nature Neuroscience
  • "Fifty Years of Research on Schizophrenia: The Ascendance of the Glutamatergic Synapse," 2020, American Journal of Psychiatry
  • "d-Serine, the Shape-Shifting NMDA Receptor Co-agonist," 2020, Neurochemical Research
  • "Postsynaptic Serine Racemase Regulates NMDA Receptor Function," 2020, Journal of Neuroscience
  • "Altered neural oscillations and behavior in a genetic mouse model of NMDA receptor hypofunction," 2021, Scientific Reports

Their frequent co-authors include Darrick T. Balu, Oluwarotimi Folorunso, Glenn Konopaske, Uwe Rudolph, and Ho-Jin Park.

Joseph T. Coyle's work has been published often in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Neuropsychopharmacology
  • Proceedings of the National Academy of Sciences
  • Molecular Psychiatry
  • Nature Neuroscience

Over the course of their career, Joseph T. Coyle has received multiple recognitions, including:

  • Rhoda and Bernard Sarnat International Prize in Mental Health, National Academy of Medicine, 2017
  • Fellow, National Academy of Inventors, 2012
  • Fellow of the American Association for the Advancement of Science (AAAS), 2004
  • Robert J. and Claire Pasarow Foundation Medical Research Award, 1996
  • Fellow of the American Academy of Arts and Sciences, 1994
  • Member of the National Academy of Medicine (NAM), 1990

Best Publications

  • Oxidative stress, glutamate, and neurodegenerative disorders

    Joseph T. Coyle;Pamela Puttfarcken

  • Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain.

    Peter J. Whitehouse;Donald L. Price;Robert G. Struble;Arthur W. Clark

  • Alzheimer's disease: a disorder of cortical cholinergic innervation

    Joseph T. Coyle;Donald L. Price;Mahlon R. DeLong

  • Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis

    Peter J. Whitehouse;Donald L. Price;Arthur W. Clark;Joseph T. Coyle

  • Oxidative Stress in Neurodegenerative Diseases

    N A Simonian;J T Coyle

  • Lesion of striatal neurones with kainic acid provides a model for Huntington's chorea.

    Joseph T. Coyle;Robert Schwarcz

  • Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia

    John E. Lisman;Joseph T. Coyle;Robert W. Green;Daniel C. Javitt

  • Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress

    Timothy H. Murphy;Masaomi Miyamoto;Antonio Sastre;Ronald L. Schnaar

  • The Emerging Role of Glutamate in the Pathophysiology and Treatment of Schizophrenia

    Donald C. Goff;Joseph T. Coyle

  • Neuropsychopharmacology : The Fifth Generation of Progress

    Kenneth L. Davis;Dennis S. Charney;Joseph T. Coyle;Charles B. Nemeroff

  • Glutamate and Schizophrenia: Beyond the Dopamine Hypothesis

    Joseph T. Coyle

  • Neurochemical aspects of the ontogenesis of gabanergic neurons in the rat brain

    J.T. Coyle;S.J. Enna

  • Catecholamines in fetal and newborn rat brain.

    J. T. Coyle;D. Henry

  • Neurobiology of schizophrenia.

    Christopher A. Ross;Russell L. Margolis;Sarah A.J. Reading;Mikhail Pletnikov

  • Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis

    Jeffrey D. Rothstein;Guochuan Tsai;Ralph W. Kuncl;Lora Clawson

  • D-serine added to antipsychotics for the treatment of schizophrenia

    Guochuan Tsai;Pinchen Yang;Li-Chen Chung;Nicholas Lange

  • Review of the toxicology of chlorpyrifos with an emphasis on human exposure and neurodevelopment.

    David L. Eaton;Robert B. Daroff;Herman Autrup;James Bridges

  • Glutamatergic Mechanisms in Schizophrenia

    Guochuan Tsai;Joseph T. Coyle

  • Immunocytochemical localization of N-acetyl-aspartate with monoclonal antibodies

    M.L. Simmons;C.G. Frondoza;J.T. Coyle

  • In situ injection of kainic acid: A new method for selectively lesioning neuronal cell bodies while sparing axons of passage

    Joseph T. Coyle;Mark E. Molliver;Michael J. Kuhar

Frequent Co-Authors

Donald L. Price
Donald L. Price Johns Hopkins University
Michael V. Johnston
Michael V. Johnston Kennedy Krieger Institute
Robert Schwarcz
Robert Schwarcz University of Maryland, Baltimore
Harvey S. Singer
Harvey S. Singer Johns Hopkins University School of Medicine
John D. Gearhart
John D. Gearhart University of Pennsylvania
Randy D. Blakely
Randy D. Blakely Florida Atlantic University
Michael B. Robinson
Michael B. Robinson Children's Hospital of Philadelphia
Solomon H. Snyder
Solomon H. Snyder Johns Hopkins University School of Medicine
Gianluigi Forloni
Gianluigi Forloni Mario Negri Institute for Pharmacological Research
Paul R. Sanberg
Paul R. Sanberg University of South Florida

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