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Genetics

D-Index
45
Citations
28272
World Ranking
4186
National Ranking
2

Overview

Heike Fiegler is affiliated with the Cyprus Institute of Neurology and Genetics in Cyprus. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with focused subfields including Infectious Diseases, Molecular Biology, Biomedical Engineering, Radiology, Nuclear Medicine and Imaging, and Cancer Research.

The scientist's work concentrates on topics related to SARS-CoV-2 and COVID-19 research, encompassing COVID-19 clinical research studies and SARS-CoV-2 detection and testing. Additional areas of study include monoclonal and polyclonal antibodies research, microfluidic and bio-sensing technologies, single-cell and spatial transcriptomics, as well as cancer genomics and diagnostics.

Frequent coauthors collaborating with Heike Fiegler include Sebastian Fiedler, Tuomas P. J. Knowles, Viola Denninger, Alison Ilsley, and Matthias M. Schneider. The common venues for publishing their research consist of bioRxiv (Cold Spring Harbor Laboratory), ACS Infectious Diseases, Life Science Alliance, Scientific Reports, and ACS Nano.

Selected recent papers authored or coauthored by Heike Fiegler include:

  • Antibody Affinity Governs the Inhibition of SARS-CoV-2 Spike/ACE2 Binding in Patient Serum, 2021, ACS Infectious Diseases
  • Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasma, 2021, Life Science Alliance
  • A flexible microfluidic system for single-cell transcriptome profiling elucidates phased transcriptional regulators of cell cycle, 2021, Scientific Reports
  • α-Synuclein Oligomers Displace Monomeric α-Synuclein from Lipid Membranes, 2024, ACS Nano
  • Microfluidic Antibody Affinity Profiling Reveals the Role of Memory Reactivation and Cross-Reactivity in the Defense Against SARS-CoV-2, 2022, ACS Infectious Diseases

Best Publications

  • Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

    Ewan Birney;John A. Stamatoyannopoulos;Anindya Dutta;Roderic Guigó

  • Global variation in copy number in the human genome

    Richard Redon;Shumpei Ishikawa;Karen R. Fitch;Lars Feuk

  • The ENCODE (ENCyclopedia of DNA elements) Project

    E. A. Feingold;P. J. Good;M. S. Guyer;S. Kamholz

  • A DNA damage checkpoint response in telomere-initiated senescence

    Fabrizio d'Adda di Fagagna;Philip M. Reaper;Lorena Clay-Farrace;Heike Fiegler

  • Diet and the evolution of human amylase gene copy number variation.

    George H Perry;Nathaniel J. Dominy;Katrina G Claw;Arthur S. Lee

  • Microarray based comparative genomic hybridisation (array-CGH) detects submicroscopic chromosomal deletions and duplications in patients with learning disability/mental retardation and dysmorphic features

    C Shaw-Smith;R Redon;L Rickman;M Rio

  • Chromatin Architecture of the Human Genome: Gene-Rich Domains Are Enriched in Open Chromatin Fibers

    Nick Gilbert;Shelagh Boyle;Heike Fiegler;Kathryn Woodfine

  • DNA microarrays for comparative genomic hybridization based on DOP-PCR amplification of BAC and PAC clones

    Heike Fiegler;Philippa Carr;Eleanor J Douglas;Deborah C Burford

  • An integrated resource for genome-wide identification and analysis of human tissue-specific differentially methylated regions (tDMRs)

    Vardhman K. Rakyan;Thomas A. Down;Natalie P. Thorne;Paul Flicek

  • Replication timing of the human genome

    Kathryn Woodfine;Heike Fiegler;David M. Beare;John E. Collins

  • Germline rates of de novo meiotic deletions and duplications causing several genomic disorders

    Daniel J Turner;Marcos Miretti;Diana Rajan;Heike Fiegler

  • Genomic and Protein Expression Profiling Identifies CDK6 As Novel Independent Prognostic Marker in Medulloblastoma

    Frank Mendrzyk;Bernhard Radlwimmer;Stefan Joos;Felix Kokocinski

  • Array-CGH detection of micro rearrangements in mentally retarded individuals: clinical significance of imbalances present both in affected children and normal parents

    Carla Rosenberg;Carla Rosenberg;J. Knijnenburg;E. Bakker;A. M. Vianna-Morgante

  • The complex nature of constitutional de novo apparently balanced translocations in patients presenting with abnormal phenotypes

    S M Gribble;E Prigmore;D C Burford;K M Porter

  • Radial chromatin positioning is shaped by local gene density, not by gene expression

    Katrin Küpper;Alexandra C Kölbl;Dorothee Biener;Sandra Dittrich

  • Array Comparative Genomic Hybridization Analysis of Colorectal Cancer Cell Lines and Primary Carcinomas

    Eleanor J. Douglas;Heike Fiegler;Andrew Rowan;Sarah Halford

  • Guidelines for molecular karyotyping in constitutional genetic diagnosis.

    Joris Robert Vermeesch;Heike Fiegler;Nicole de Leeuw;Karoly Szuhai

  • High resolution array-CGH analysis of single cells

    Heike Fiegler;Jochen B. Geigl;Sabine Langer;Diane Rigler

  • Prenatal detection of unbalanced chromosomal rearrangements by array CGH

    Lisa Rickman;Heike Fiegler;Charles Shaw-Smith;Richard Nash

  • Accurate and reliable high-throughput detection of copy number variation in the human genome

    Heike Fiegler;Richard Redon;Dan Andrews;Carol Scott

Frequent Co-Authors

Nigel P. Carter
Nigel P. Carter Wellcome Sanger Institute
Ian Tomlinson
Ian Tomlinson University of Oxford
Ian Dunham
Ian Dunham European Bioinformatics Institute
Richard Redon
Richard Redon University of Nantes
Cordelia Langford
Cordelia Langford Wellcome Sanger Institute
Matthew E. Hurles
Matthew E. Hurles Wellcome Sanger Institute
Michael R. Speicher
Michael R. Speicher Medical University of Graz
Andrew J. Mungall
Andrew J. Mungall BC Cancer Agency
Emmanouil T. Dermitzakis
Emmanouil T. Dermitzakis University of Geneva
Eric S. Lander
Eric S. Lander Broad Institute

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