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Chemistry

D-Index
73
Citations
20110
World Ranking
4930
National Ranking
1543

Overview

Barbara S. Slusher is affiliated with Johns Hopkins University School of Medicine in the United States. Their research spans multiple disciplines, primarily within biochemistry, genetics, and molecular biology, alongside medicine. The body of their work includes a significant focus on molecular biology, neurology, immunology, physiology, and cancer research.

The main scientific topics addressed in their research include cancer, hypoxia, and metabolism; neuroinflammation and neurodegeneration mechanisms; extracellular vesicles in disease; immune cells in cancer; epigenetics and DNA methylation; sphingolipid metabolism and signaling; and cancer research and treatments.

Slusher's publications appear frequently in prominent venues where they have contributed extensively. The most common journals and platforms include bioRxiv (Cold Spring Harbor Laboratory), the Journal of Medicinal Chemistry, Cancer Research, Gastroenterology, and Neurotherapeutics.

Frequent collaborators in the research by Slusher include Rana Rais, Ajit G. Thomas, Jesse Alt, Takashi Tsukamoto, and Lukáš Tenora. These coauthors have contributed to multiple projects alongside Slusher, signaling sustained collaborative relationships.

Among recent scientific papers associated with Barbara S. Slusher are the following:

  • "Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells" (2020, Journal of Clinical Investigation)
  • "Characterization of extracellular vesicles and synthetic nanoparticles with four orthogonal single-particle analysis platforms" (2021, Journal of Extracellular Vesicles)
  • "Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug" (2022, Science Advances)
  • "Targeting Glutamine Metabolism to Enhance Immunoprevention of EGFR-Driven Lung Cancer" (2022, Advanced Science)
  • "Phosphonates and Phosphonate Prodrugs in Medicinal Chemistry: Past Successes and Future Prospects" (2022, Frontiers in Chemistry)

Best Publications

  • Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

    Scott J Dixon;Darpan N Patel;Matthew Welsch;Rachid Skouta

  • Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells

    Anne Le;Andrew N. Lane;Max Hamaker;Sminu Bose

  • Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

    Robert D. Leone;Liang Zhao;Judson M. Englert;Im Meng Sun

  • Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1.

    Meghan J. Seltzer;Bryson D. Bennett;Avadhut D. Joshi;Ping Gao

  • Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis

    Yan Xiang;Zachary E. Stine;Jinsong Xia;Yunqi Lu

  • Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells

    Min Hee Oh;Im Hong Sun;Liang Zhao;Robert D. Leone

  • Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury.

    Barbara S. Slusher;James J. Vornov;Ajit G. Thomas;Patricia D. Hurn

  • Biodistribution, Tumor Detection, and Radiation Dosimetry of 18F-DCFBC, a Low-Molecular-Weight Inhibitor of Prostate-Specific Membrane Antigen, in Patients with Metastatic Prostate Cancer

    Steve Y. Cho;Kenneth L. Gage;Ronnie C. Mease;Srinivasan Senthamizhchelvan

  • Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer.

    Jeroen R Mesters;Cyril Barinka;Weixing Li;Takashi Tsukamoto

  • Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase N-acetylated α-linked acidic dipeptidase

    Paul F. Jackson;Derek C. Cole;Barbara S. Slusher;Susan L. Stetz

  • Palonosetron exhibits unique molecular interactions with the 5-HT3 receptor.

    Camilo Rojas;Marigo Stathis;Ajit G. Thomas;Edward B. Massuda

  • Glutamate Carboxypeptidase II in Diagnosis and Treatment of Neurologic Disorders and Prostate Cancer

    C. Bařinka;C. Rojas;B. Slusher;M. Pomper

  • Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors.

    Krupa Shukla;Dana V. Ferraris;Ajit G. Thomas;Marigo Stathis

  • Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer

    Amira Elgogary;Qingguo Xu;Brad Poore;Jesse Alt

  • We're Not "DON" Yet: Optimal Dosing and Prodrug Delivery of 6-Diazo-5-oxo-L-norleucine.

    Kathryn M. Lemberg;James J. Vornov;James J. Vornov;Rana Rais;Barbara S. Slusher

  • Palonosetron triggers 5-HT3 receptor internalization and causes prolonged inhibition of receptor function

    Camilo Rojas;Ajit G. Thomas;Jesse Alt;Marigo Stathis

  • Characterization of extracellular vesicles and synthetic nanoparticles with four orthogonal single‐particle analysis platforms

    Tanina Arab;Emily R. Mallick;Yiyao Huang;Liang Dong

  • Molecular mechanisms of 5-HT3 and NK1 receptor antagonists in prevention of emesis

    Camilo Rojas;Mithun Raje;Takashi Tsukamoto;Barbara S. Slusher

  • Immunocytochemical localization of the N-acetyl-aspartyl-glutamate (NAAG) hydrolyzing enzyme N-acetylated α-linked acidic dipeptidase (NAALADase)

    Barbara Stauch Slusher;Guochuan Tsai;Grace Yoo;Joseph T. Coyle

  • Rat brain N-acetylated alpha-linked acidic dipeptidase activity. Purification and immunologic characterization.

    B S Slusher;M B Robinson;G Tsai;M L Simmons

  • In vitro and In vivo Radiosensitization of Glioblastoma Cells by the Poly (ADP-Ribose) Polymerase Inhibitor E7016

    Andrea L. Russo;Hyuk-Chan Kwon;William E. Burgan;William E. Burgan;Donna Carter;Donna Carter

Frequent Co-Authors

Jonathan D. Powell
Jonathan D. Powell Johns Hopkins University School of Medicine
Norman J. Haughey
Norman J. Haughey Tulane University
Charles G. Eberhart
Charles G. Eberhart Johns Hopkins University School of Medicine
Jan Konvalinka
Jan Konvalinka Czech Academy of Sciences
Amy Hauck Newman
Amy Hauck Newman National Institutes of Health
Martin G. Pomper
Martin G. Pomper Johns Hopkins University School of Medicine
David J. Volsky
David J. Volsky Icahn School of Medicine at Mount Sinai
Joseph T. Coyle
Joseph T. Coyle Harvard University
Guido Cavaletti
Guido Cavaletti University of Milano-Bicocca
Zheng-Xiong Xi
Zheng-Xiong Xi National Institutes of Health

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