Paul S. Hoffman

Overview

Best Publications

• Metronidazole resistance in Helicobacter pylori is due to null mutations in a gene (rdxA) that encodes an oxygen‐insensitive NADPH nitroreductase

  Goodwin A;Kersulyte D;Sisson G;Veldhuyzen van Zanten Sj

  513
  Citations

• Surface-associated hsp60 chaperonin of Legionella pneumophila mediates invasion in a HeLa cell model.

  Rafael A. Garduño;Elizabeth Garduño;Paul S. Hoffman

  309
  Citations

• Antiparasitic drug nitazoxanide inhibits the pyruvate oxidoreductases of Helicobacter pylori, selected anaerobic bacteria and parasites, and Campylobacter jejuni

  Paul S. Hoffman;Gary Sisson;Matthew A. Croxen;Kevin Welch

  289
  Citations

• Essential Thioredoxin-Dependent Peroxiredoxin System from Helicobacter pylori: Genetic and Kinetic Characterization

  Laura M. S. Baker;Ausra Raudonikiene;Paul S. Hoffman;Leslie B. Poole

  265
  Citations

• Treatment of intestinal parasitic infections: a review of nitazoxanide

  Herbert M Gilles;Paul S Hoffman

  222
  Citations

• The Helicobacter pylori chemotaxis receptor TlpB (HP0103) is required for pH taxis and for colonization of the gastric mucosa.

  Matthew A. Croxen;Gary Sisson;Roberto Melano;Paul S. Hoffman

  222
  Citations

• Intracellular Growth of Legionella pneumophila Gives Rise to a Differentiated Form Dissimilar to Stationary-Phase Forms

  Rafael A. Garduño;Elizabeth Garduño;Margot Hiltz;Paul S. Hoffman

  218
  Citations

• Enzymes Associated with Reductive Activation and Action of Nitazoxanide, Nitrofurans, and Metronidazole in Helicobacter pylori

  Gary Sisson;Avery Goodwin;Ausra Raudonikiene;Nicky J. Hughes

  217
  Citations

• Acidic pH changes receptor binding specificity of Helicobacter pylori: a binary adhesion model in which surface heat shock (stress) proteins mediate sulfatide recognition in gastric colonization.

  M Huesca;S Borgia;P Hoffman;C A Lingwood

  197
  Citations

• Systematic Identification of Selective Essential Genes in Helicobacter pylori by Genome Prioritization and Allelic Replacement Mutagenesis

  Alison F. Chalker;Heather W. Minehart;Nicky J. Hughes;Kristin K. Koretke

  195
  Citations

• Sequential Inactivation of rdxA (HP0954) and frxA (HP0642) Nitroreductase Genes Causes Moderate and High-Level Metronidazole Resistance in Helicobacter pylori

  Jy Jeong;AK Mukhopadhyay;D Dailidiene;Y Wang

  178
  Citations

• Metronidazole activation is mutagenic and causes DNA fragmentation in Helicobacter pylori and in Escherichia coli containing a cloned H. pylori RdxA(+) (Nitroreductase) gene.

  Gary Sisson;Jin-Yong Jeong;Avery Goodwin;Louis Bryden

  174
  Citations

• Metabolic activities of metronidazole-sensitive and -resistant strains of Helicobacter pylori: repression of pyruvate oxidoreductase and expression of isocitrate lyase activity correlate with resistance.

  P. S. Hoffman;A. Goodwin;J. Johnsen;K. Magee

  174
  Citations

• Immunolocalization of Hsp60 in Legionella pneumophila

  Rafael A. Garduño;Gary Faulkner;Mary A. Trevors;Neeraj Vats

  162
  Citations

• Flavodoxin:Quinone Reductase (FqrB): a Redox Partner of Pyruvate:Ferredoxin Oxidoreductase That Reversibly Couples Pyruvate Oxidation to NADPH Production in Helicobacter pylori and Campylobacter jejuni

  Martin St. Maurice;Nunilo Cremades;Matthew A. Croxen;Gary Sisson

  150
  Citations

• Persistent G. lamblia impairs growth in a murine malnutrition model.

  Luther A. Bartelt;James Roche;Glynis Kolling;David Bolick

  126
  Citations

• Germination and Amplification of Anthrax Spores by Soil-Dwelling Amoebas

  Rafik Dey;Paul S. Hoffman;Ian J. Glomski

  123
  Citations

• Elevated levels of Legionella pneumophila stress protein Hsp60 early in infection of human monocytes and L929 cells correlate with virulence.

  R C Fernandez;S M Logan;S H Lee;P S Hoffman

  122
  Citations

• Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer.

  Yi Qu;Yi Qu;Yi Qu;Jan Roger Olsen;Xing Yuan;Phil F Cheng

  120
  Citations

• Roles of FrxA and RdxA nitroreductases of Helicobacter pylori in susceptibility and resistance to metronidazole.

  Jin-Yong Jeong;Asish K. Mukhopadhyay;Junko K. Akada;Daiva Dailidiene

  119
  Citations