World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
79
Citations
26480
World Ranking
4253
National Ranking
2083

Overview

Andrew N. Lane is affiliated with the University of Kentucky in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with a total of 112 publications, and Medicine, contributing 42 publications.

The scientist's work covers multiple subfields of study, including Molecular Biology, Cancer Research, Immunology, Oncology, and Spectroscopy. Within these areas, Lane focuses on topics such as Cancer, Hypoxia, and Metabolism; Metabolomics and Mass Spectrometry Studies; Epigenetics and DNA Methylation; Immune cells in cancer; Metabolism and Genetic Disorders; Immune Cell Function and Interaction; and Cancer-related Molecular Pathways.

Lane's recent scholarly papers demonstrate a focus on immune cell metabolism and cancer biology. Notable recent publications include:

  • Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase, 2020, Nature Communications
  • Inosine is an alternative carbon source for CD8+-T-cell function under glucose restriction, 2020, Nature Metabolism
  • Mitochondrial DNA alterations underlie an irreversible shift to aerobic glycolysis in fumarate hydratase-deficient renal cancer, 2021, Science Signaling
  • Asparagine restriction enhances CD8+ T cell metabolic fitness and antitumoral functionality through an NRF2-dependent stress response, 2023, Nature Metabolism
  • Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation, 2022, Science Immunology

Frequent publication venues for Lane include Cancer Research, Metabolites, bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, and Nature Metabolism. Cancer Research is the most frequent venue, with nine publications, followed by five each in Metabolites and bioRxiv, and three each in Nature Communications and Nature Metabolism.

Collaboration is a key component of Lane's work, with frequent co-authors including Teresa W.-M. Fan (43 co-authored papers), Richard M. Higashi (34 papers), Penghui Lin (20 papers), Teresa Cassel (15 papers), and Daniel R. Crooks (9 papers).

Best Publications

  • Proposed minimum reporting standards for chemical analysis

    Lloyd W. Sumner;Alexander Amberg;Dave Barrett;Michael H. Beale

  • Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells

    Anne Le;Andrew N. Lane;Max Hamaker;Sminu Bose

  • Stability and kinetics of G-quadruplex structures

    Andrew N. Lane;J. Brad Chaires;Robert D. Gray;John O. Trent

  • Regulation of mammalian nucleotide metabolism and biosynthesis

    Andrew N. Lane;Teresa W.-M. Fan

  • Metabolomics enables precision medicine: "A White Paper, Community Perspective"

    Richard D. Beger;Warwick Dunn;Michael A. Schmidt;Steven S. Gross

  • Altered regulation of metabolic pathways in human lung cancer discerned by 13C stable isotope-resolved metabolomics (SIRM)

    Teresa Wm Fan;Andrew N. Lane;Richard M. Higashi;Mohamed A Elahadi Farag

  • Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC.

    Wei Liu;Anne Le;Chad Hancock;Andrew N. Lane

  • Targeting lactate dehydrogenase-A inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor initiating cells

    Han Xie;Jun-ichi Hanai;Jian-Guo Ren;Lev Kats

  • Pyruvate carboxylase is critical for non–small-cell lung cancer proliferation

    Katherine Sellers;Matthew P. Fox;Michael Bousamra;Stephen P. Slone

  • Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth

    Brian Clem;Sucheta Telang;Amy Clem;Abdullah Yalcin

  • Targeting aspartate aminotransferase in breast cancer

    Joshua Marshall Thornburg;Kristin K Nelson;Brian F Clem;Andrew N Lane

  • Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase.

    Erika M. Palmieri;Marieli Gonzalez-Cotto;Walter A. Baseler;Luke C. Davies

  • Hydration is a major determinant of the G-quadruplex stability and conformation of the human telomere 3' sequence of d(AG3(TTAG3)3).

    M. Clarke Miller;Robert Buscaglia;Jonathan B. Chaires;Andrew N. Lane

  • Under normoxia, 2-deoxy-d-glucose elicits cell death in select tumor types not by inhibition of glycolysis but by interfering with N-linked glycosylation

    Metin Kurtoglu;Ningguo Gao;Jie Shang;Johnathan C. Maher

  • Structure-based profiling of metabolites and isotopomers by NMR

    Teresa W.-M. Fan;Andrew N. Lane

  • Nuclear targeting of 6-phosphofructo-2-kinase (PFKFB3) increases proliferation via cyclin-dependent kinases.

    Abdullah Yalcin;Abdullah Yalcin;Brian F. Clem;Alan Simmons;Andrew Lane

  • Control of Glutamine Metabolism By the Tumor Suppressor Rb

    Miriam R. Reynolds;Andrew N. Lane;Brian Robertson;Sharen Kemp

  • Comprehensive chemical profiling of gramineous plant root exudates using high-resolution NMR and MS

    Teresa W.-M. Fan;Andrew N. Lane;Moshe Shenker;John P. Bartley

  • Stable isotope-resolved metabolomics and applications for drug development

    Teresa W.-M. Fan;Pawel K. Lorkiewicz;Katherine Sellers;Hunter N.B. Moseley

  • Applications of NMR spectroscopy to systems biochemistry.

    Teresa W.-M. Fan;Andrew N. Lane

Frequent Co-Authors

Teresa W.-M. Fan
Teresa W.-M. Fan University of Kentucky
Richard M. Higashi
Richard M. Higashi University of Kentucky
Tom Brown
Tom Brown University of Oxford
Jun Yan
Jun Yan University of Louisville
W. Marston Linehan
W. Marston Linehan National Institutes of Health
John O. Trent
John O. Trent University of Louisville
Oleg Jardetzky
Oleg Jardetzky Stanford University
Jason Chesney
Jason Chesney University of Louisville
Tracey A. Rouault
Tracey A. Rouault National Institutes of Health
Afaf H. El-Sagheer
Afaf H. El-Sagheer University of Southampton

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Best Scientists Citing Andrew N. Lane

Trending Scientists

Recently Published Articles