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Chemistry

D-Index
44
Citations
7404
World Ranking
16818
National Ranking
925

Overview

Afaf H. El-Sagheer is affiliated with the University of Southampton in the United Kingdom. Their research primarily spans the field of Biochemistry, Genetics and Molecular Biology, with a focus on subfields such as Molecular Biology, Organic Chemistry, Materials Chemistry, Genetics, and Electrical and Electronic Engineering.

Their main research topics include:

  • Advanced biosensing and bioanalysis techniques
  • RNA Interference and Gene Delivery
  • DNA and Nucleic Acid Chemistry
  • Click Chemistry and Applications
  • RNA and protein synthesis mechanisms
  • Genomics and Chromatin Dynamics
  • RNA modifications and cancer

Recent significant papers authored or co-authored by Afaf H. El-Sagheer include:

  • "A Hitchhiker's Guide to Click-Chemistry with Nucleic Acids" (2021), published in Chemical Reviews
  • "Dynamics of the 4D genome during in vivo lineage specification and differentiation" (2020), published in Nature Communications
  • "DNA Gold Nanoparticle Motors Demonstrate Processive Motion with Bursts of Speed Up to 50 nm Per Second" (2021), published in ACS Nano
  • "High-resolution targeted 3C interrogation of cis-regulatory element organization at genome-wide scale" (2021), published in Nature Communications
  • "Expanding the chemical functionality of DNA nanomaterials generated by rolling circle amplification" (2021), published in Nucleic Acids Research

Afaf H. El-Sagheer frequently publishes in the following venues:

  • Journal of the American Chemical Society
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Nucleic Acids Research
  • Angewandte Chemie International Edition

Their collaborative network includes regular co-authors such as Tom Brown, Arun Shivalingam, Ysobel R. Baker, Antonios G. Kanaras, and Matthew J. A. Wood.

Best Publications

  • Click chemistry with DNA

    Afaf H. El-Sagheer;Afaf H. El-Sagheer;Tom Brown

  • A Hitchhiker's Guide to Click-Chemistry with Nucleic Acids.

    Nicolò Zuin Fantoni;Afaf H. El-Sagheer;Afaf H. El-Sagheer;Tom Brown

  • Template-directed oligonucleotide strand ligation, covalent intramolecular DNA circularization and catenation using click chemistry.

    Ravindra Kumar;Afaf El-Sagheer;John Tumpane;Per Lincoln

  • Click Nucleic Acid Ligation: Applications in Biology and Nanotechnology

    Afaf H. El-Sagheer;Tom Brown

  • Nucleic acid base analog fret-pair facilitating detailed structural measurements in nucleic acid containing systems

    Karl Börjesson;Søren Preus;Afaf H. El-Sagheer;Tom Brown

  • Highly Sensitive DNA Sensor Based on Upconversion Nanoparticles and Graphene Oxide

    P. Alonso-Cristobal;P. Vilela;A. El-Sagheer;E. Lopez-Cabarcos

  • Biocompatible artificial DNA linker that is read through by DNA polymerases and is functional in Escherichia coli

    Afaf H. El-Sagheer;A. Pia Sanzone;Rachel Gao;Ali Tavassoli

  • New strategy for the synthesis of chemically modified RNA constructs exemplified by hairpin and hammerhead ribozymes

    Afaf H. El-Sagheer;Tom Brown

  • An autonomous molecular assembler for programmable chemical synthesis

    Wenjing Meng;Richard A. Muscat;Mireya L. McKee;Phillip J. Milnes

  • Synthesis and Polymerase Chain Reaction Amplification of DNA Strands Containing an Unnatural Triazole Linkage

    Afaf H El-Sagheer;Tom Brown

  • Fast copper-free click DNA ligation by the ring-strain promoted alkyne-azide cycloaddition reaction.

    Montserrat Shelbourne;Xiong Chen;Tom Brown;Afaf H. El-Sagheer;Afaf H. El-Sagheer

  • Multiplexed mRNA Sensing and Combinatorial-Targeted Drug Delivery Using DNA-Gold Nanoparticle Dimers.

    Maria Eleni Kyriazi;Davide Giust;Afaf H. El-Sagheer;Afaf H. El-Sagheer;Peter M. Lackie

  • Rapid and Efficient DNA Strand Cross-Linking by Click Chemistry

    Petr Kočalka;Afaf H. El-Sagheer;Tom Brown

  • Graphene Oxide-Upconversion Nanoparticle Based Optical Sensors for Targeted Detection of mRNA Biomarkers Present in Alzheimer's Disease and Prostate Cancer.

    Patrick Vilela;Afaf El-Sagheer;Afaf El-Sagheer;Timothy M. Millar;Tom Brown

  • Synthesis of Trifluoromethylnaphthalenes

    John M Mellor;Afaf H El-Sagheer;El-Sayed H El-Tamany;Reda N Metwally

  • Dynamics of the 4D genome during in vivo lineage specification and differentiation.

    A M Oudelaar;R A Beagrie;M Gosden;S de Ornellas

  • Tension induces a base-paired overstretched DNA conformation

    Niklas Bosaeus;Afaf H. El-Sagheer;Tom Brown;Steven B. Smith

  • Graphene Oxide–Upconversion Nanoparticle Based Portable Sensors for Assessing Nutritional Deficiencies in Crops

    Davide Giust;María Isabel Lucío;Afaf H. El-Sagheer;Afaf H. El-Sagheer;Tom Brown

  • Transcription of Click‐Linked DNA in Human Cells

    CN Birts;AP Sanzone;AH El-Sagheer;AH El-Sagheer;JP Blaydes

  • Assembly of a biocompatible triazole-linked gene by one-pot click-DNA ligation

    Mikiembo Kukwikila;Nittaya Gale;Afaf H. El-Sagheer;Afaf H. El-Sagheer;Tom Brown

  • Structural insights into how 5-hydroxymethylation influences transcription factor binding.

    Lukas Lercher;Michael A. McDonough;Afaf H. El-Sagheer;Armin Thalhammer

Frequent Co-Authors

Tom Brown
Tom Brown University of Oxford
Otto L. Muskens
Otto L. Muskens University of Southampton
Bengt Nordén
Bengt Nordén Chalmers University of Technology
James Hughes
James Hughes Emory University
Christopher J. Schofield
Christopher J. Schofield University of Oxford
Richard O.C. Oreffo
Richard O.C. Oreffo University of Southampton
Veronica J. Buckle
Veronica J. Buckle University of Oxford
Thomas M. Brown
Thomas M. Brown University of Rome Tor Vergata
Bo Albinsson
Bo Albinsson Chalmers University of Technology
Michel Arthur
Michel Arthur Centre de Recherche des Cordeliers

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