Her main research concerns DNA, Oligonucleotide, Combinatorial chemistry, Base pair and Click chemistry. Her DNA study frequently draws parallels with other fields, such as Ligation. Her Oligonucleotide study combines topics in areas such as Yield, Nucleic acid thermodynamics, Nucleic acid and Biophysical chemistry.
In her research on the topic of Nucleic acid, Nucleobase and Base analog is strongly related with Organic chemistry. Her Combinatorial chemistry research is multidisciplinary, relying on both Nanotechnology, Hammerhead ribozyme, Chemical ligation, Stem-loop and A-DNA. Afaf H. El-Sagheer interconnects RNA, Hairpin ribozyme, Uracil and VS ribozyme in the investigation of issues within Click chemistry.
DNA, Oligonucleotide, Combinatorial chemistry, Biochemistry and Nanotechnology are her primary areas of study. Afaf H. El-Sagheer has included themes like Biophysics, Nucleic acid, Click chemistry and Stereochemistry in her DNA study. Her work in the fields of Oligonucleotide, such as Phosphoramidite, overlaps with other areas such as Alkyne.
Her research in Combinatorial chemistry intersects with topics in Yield, Triazole, Organic chemistry, Azide and Polymerase. Her work in Biochemistry addresses subjects such as Molecular biology, which are connected to disciplines such as Transcription. As a part of the same scientific study, Afaf H. El-Sagheer usually deals with the Nanotechnology, concentrating on Analyte and frequently concerns with Aptamer.
Her scientific interests lie mostly in Oligonucleotide, DNA, Nucleic acid, Combinatorial chemistry and Cell biology. Her work deals with themes such as Computational biology, Nanotechnology and Click chemistry, which intersect with Oligonucleotide. The DNA study combines topics in areas such as Biophysics, Fluorophore and Circular dichroism.
Her biological study deals with issues like RNA, which deal with fields such as Genome editing. Her Combinatorial chemistry course of study focuses on Polymerase and Ligation and Chemical ligation. Her Cell biology research is multidisciplinary, incorporating elements of Adipose tissue and Enhancer.
Afaf H. El-Sagheer mostly deals with DNA, Oligonucleotide, Cleavage, Click chemistry and Computational biology. Her DNA research incorporates themes from Förster resonance energy transfer, Biophysics, Nucleic acid and Fluorophore. Her Nucleic acid study combines topics from a wide range of disciplines, such as RNA, Quantum yield and Uracil.
Her Cleavage study incorporates themes from Nucleotide, Endonuclease, Transcription activator-like effector nuclease, Stereochemistry and Small molecule. Her Click chemistry research includes themes of Cleave and Phenanthroline. Her Computational biology research also works with subjects such as
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Click chemistry with DNA
Afaf H. El-Sagheer;Afaf H. El-Sagheer;Tom Brown.
Chemical Society Reviews (2010)
Template-directed oligonucleotide strand ligation, covalent intramolecular DNA circularization and catenation using click chemistry.
Ravindra Kumar;Afaf El-Sagheer;John Tumpane;Per Lincoln.
Journal of the American Chemical Society (2007)
Click Nucleic Acid Ligation: Applications in Biology and Nanotechnology
Afaf H. El-Sagheer;Tom Brown.
Accounts of Chemical Research (2012)
Nucleic acid base analog fret-pair facilitating detailed structural measurements in nucleic acid containing systems
Karl Börjesson;Søren Preus;Afaf H. El-Sagheer;Tom Brown.
Journal of the American Chemical Society (2009)
New strategy for the synthesis of chemically modified RNA constructs exemplified by hairpin and hammerhead ribozymes
Afaf H. El-Sagheer;Tom Brown.
Proceedings of the National Academy of Sciences of the United States of America (2010)
Biocompatible artificial DNA linker that is read through by DNA polymerases and is functional in Escherichia coli
Afaf H. El-Sagheer;A. Pia Sanzone;Rachel Gao;Ali Tavassoli.
Proceedings of the National Academy of Sciences of the United States of America (2011)
Highly Sensitive DNA Sensor Based on Upconversion Nanoparticles and Graphene Oxide
P. Alonso-Cristobal;P. Vilela;A. El-Sagheer;E. Lopez-Cabarcos.
ACS Applied Materials & Interfaces (2015)
Synthesis and Polymerase Chain Reaction Amplification of DNA Strands Containing an Unnatural Triazole Linkage
Afaf H El-Sagheer;Tom Brown.
Journal of the American Chemical Society (2009)
Fast copper-free click DNA ligation by the ring-strain promoted alkyne-azide cycloaddition reaction.
Montserrat Shelbourne;Xiong Chen;Tom Brown;Afaf H. El-Sagheer;Afaf H. El-Sagheer.
Chemical Communications (2011)
Synthesis of Trifluoromethylnaphthalenes
John M Mellor;Afaf H El-Sagheer;El-Sayed H El-Tamany;Reda N Metwally.
Tetrahedron (2000)
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