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D-Index
65
Citations
14731
World Ranking
7681
National Ranking
550

Overview

Frank Seela is affiliated with the University of Münster in Germany. Their research primarily focuses on biochemistry, genetics, and molecular biology, with significant contributions within the molecular biology subfield. Their work also spans organic chemistry, materials chemistry, infectious diseases, and radiology, nuclear medicine, and imaging.

The scientist's research topics cover DNA and nucleic acid chemistry, advanced biosensing and bioanalysis techniques, click chemistry and applications, HIV/AIDS drug development and treatment, RNA interference and gene delivery, RNA and protein synthesis mechanisms, and crystallization and solubility studies.

Frequent publication venues for their work include:

  • Chemistry - A European Journal
  • The Journal of Organic Chemistry
  • Bioconjugate Chemistry
  • Acta Crystallographica Section C Structural Chemistry
  • The Cambridge Structural Database

Recent papers authored by or involving Frank Seela cover various aspects of nucleic acid chemistry and molecular recognition:

  • The 2-Amino Group of 8-Aza-7-deaza-7-bromopurine-2,6-diamine and Purine-2,6-diamine as Stabilizer for the Adenine-Thymine Base Pair in Heterochiral DNA with Strands in Anomeric Configuration, 2020, Chemistry - A European Journal
  • Heterochiral DNA with Complementary Strands with α-d and β-d Configurations: Hydrogen-Bonded and Silver-Mediated Base Pairs with Impact of 7-Deazapurines Replacing Purines, 2020, Chemistry - A European Journal
  • Isoguanine (2-Hydroxyadenine) and 2-Aminoadenine Nucleosides with an 8-Aza-7-deazapurine Skeleton: Synthesis, Functionalization with Fluorescent and Clickable Side Chains, and Impact of 7-Substituents on Physical Properties, 2021, The Journal of Organic Chemistry
  • 5-Aza-7-deazaguanine-Isoguanine and Guanine-Isoguanine Base Pairs in Watson-Crick DNA: The Impact of Purine Tracts, Clickable Dendritic Side Chains, and Pyrene Adducts, 2021, Chemistry - A European Journal
  • DNA with Purine-Purine Base Pairs: Size and Position of Isoguanine and 8-Aza-7-deazaisoguanine Clickable Residues Control the Molecular Recognition of Guanine and 5-Aza-7-deazaguanine, 2022, The Journal of Organic Chemistry

Collaborating frequently with other researchers, Frank Seela has coauthored numerous publications with:

  • Dasharath Kondhare
  • Peter Leonard
  • Simone Budow-Busse
  • Aigui Zhang
  • Constantin G. Daniliuc

Best Publications

  • Improvement of the dideoxy chain termination method of DNA sequencing by use of deoxy-7-deazaguanosine triphosphate in place of dGTP

    Saeko Mizusawa;Susumu Nishimura;Frank Seela

  • 1′, 5′ -Anhydrohexitol Oligonucleotides: Synthesis, Base Pairing and Recognition by Regular Oligodeoxyribonucleotides and Oligoribonucleotides

    Chris Hendrix;Helmut Rosemeyer;Ilse Verheggen;Arthur Van Aerschot

  • Syn-anti conformational analysis of regular and modified nucleosides by 1D 1H NOE difference spectroscopy: a simple graphical method based on conformationally rigid molecules

    Helmut Rosemeyer;Gabor Toth;Bozenna Golankiewicz;Zygmunt Kazimierczuk

  • Cyclohexene Nucleic Acids (CeNA): Serum Stable Oligonucleotides that Activate RNase H and Increase Duplex Stability with Complementary RNA

    Jing Wang;Birgit Verbeure;Ingrid Luyten;Eveline Lescrinier

  • Modification of DNA with Octadiynyl Side Chains : Synthesis, Base Pairing, and Formation of Fluorescent Coumarin Dye Conjugates of Four Nucleobases by the Alkyne-Azide Click Reaction

    Frank Seela;Venkata Ramana Sirivolu;Padmaja Chittepu

  • Oligodeoxyribonucleotides containing 1, 3-propanediol as nucleoside substitute

    Frank Seela;Klaus Kaiser

  • A Ratiometric Fluorescent On–Off Zn2+ Chemosensor Based on a Tripropargylamine Pyrene Azide Click Adduct

    Sachin A. Ingale;Frank Seela;Frank Seela

  • Synthesis of 7-deaza-2'deoxyguanosine nucleotides

    Frank Seela

  • Synthesis of 2-amino-7-(2'-deoxy-β-D-erythro-pentofuranosyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, a new isostere of 2'-deoxyguanosine

    Heinz Dieter Winkeler;Frank Seela

  • Palindromic octa- and dodecanucleotides containing 2'-deoxytubercidin: synthesis, hairpin formation, and recognition by the endodeoxyribonuclease EcoRI.

    Frank Seela;Andreas Kehne

  • Incorporation of a complete set of deoxyadenosine and thymidine analogues suitable for the study of protein nucleic acid interactions into oligodeoxynucleotides. Application to the EcoRV restriction endonuclease and modification methylase.

    Patrick C. Newman;Victor U. Nwosu;David M. Williams;Richard Cosstick

  • "Double click" reaction on 7-deazaguanine DNA: synthesis and excimer fluorescence of nucleosides and oligonucleotides with branched side chains decorated with proximal pyrenes.

    Frank Seela;Sachin A. Ingale

  • DNA Containing Side Chains with Terminal Triple Bonds: Base-Pair Stability and Functionalization of Alkynylated Pyrimidines and 7-Deazapurines

    Frank Seela;Venkata Ramana Sirivolu

  • Nucleosides and oligonucleotides containing 1,2,3-triazole residues with nucleobase tethers: synthesis via the azide-alkyne 'click' reaction.

    Padmaja Chittepu;Venkata Ramana Sirivolu;Venkata Ramana Sirivolu;Frank Seela;Frank Seela

  • Duplex Stabilization of DNA: Oligonucleotides containing 7‐substituted 7‐deazaadenines

    Frank Seela;Horst Thomas

  • Nucleosides and Oligonucleotides with Diynyl Side Chains: Base Pairing and Functionalization of 2′‐Deoxyuridine Derivatives by the Copper(I)‐Catalyzed AlkyneAzide ‘Click’ Cycloaddition

    Frank Seela;Venkata Ramana Sirivolu

  • Alternating d(G-C)3 and d(C-G)3 hexanucleotides containing 7-deaza-2'-deoxyguanosine or 8-aza-7-deaza-2'-deoxyguanosine in place of dG.

    Frank Seela;Hansjürgen Driller

  • 1',5'-anhydrohexitol oligonucleotides: Hybridisation and strand displacement with oligoribonucleotides, interaction with RNase H and HIV reverse transcriptase

    Chris Hendrix;Helmut Rosemeyer;Bart De Bouvere;Arthur Van Aerschot

  • D-Altritol Nucleic Acids (ANA): Hybridisation Properties, Stability, and Initial Structural Analysis

    Brigitte Allart;Kamran Khan;Helmut Rosemeyer;Guy Schepers

  • Nucleic acid binding compounds containing pyrazolo[3,4-d]pyrimidine analogues of purin-2,6-diamine and their uses

    Frank Seela;Frank Bergmann;Herbert von der Eltz;Dieter Heindl

Frequent Co-Authors

Constantin G. Daniliuc
Constantin G. Daniliuc University of Münster
Leonid Beigelman
Leonid Beigelman Johnson & Johnson
Markus Sauer
Markus Sauer University of Würzburg
Heinz-Jürgen Steinhoff
Heinz-Jürgen Steinhoff Osnabrück University
Bernard A. Connolly
Bernard A. Connolly Newcastle University
Michael J. Gait
Michael J. Gait MRC Laboratory of Molecular Biology
Lifeng Chi
Lifeng Chi Soochow University
Robert H. Silverman
Robert H. Silverman Kent State University
Harald Fuchs
Harald Fuchs University of Münster

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