His primary scientific interests are in Stereochemistry, Oligonucleotide, DNA, Base pair and Phosphoramidite. The Pyrimidine research he does as part of his general Stereochemistry study is frequently linked to other disciplines of science, such as Sonogashira coupling, therefore creating a link between diverse domains of science. He has researched Oligonucleotide in several fields, including Duplex, Moiety, Nucleoside and Combinatorial chemistry, Click chemistry.
His DNA course of study focuses on Phosphodiester bond and DNA ligase, Taq polymerase, DNA clamp, DNA replication and 8-aza-7-deazaadenine. The study incorporates disciplines such as Crystallography and Antiparallel in addition to Base pair. His Phosphoramidite research is multidisciplinary, incorporating elements of Covalent bond, Bicyclic molecule and Hoogsteen base pair.
His scientific interests lie mostly in Stereochemistry, Oligonucleotide, Base pair, DNA and Nucleobase. His studies in Stereochemistry integrate themes in fields like Phosphoramidite, Glycosylation and Nucleic acid. Frank Seela combines subjects such as Combinatorial chemistry, Duplex and Moiety with his study of Oligonucleotide.
His Base pair research includes elements of Antiparallel, Isoguanine, Guanine, Deoxyadenosine and Metal. His biological study focuses on Cytosine. Cycloaddition is closely connected to Click chemistry in his research, which is encompassed under the umbrella topic of Nucleobase.
His primary areas of study are Stereochemistry, Oligonucleotide, Base pair, DNA and Nucleobase. The various areas that Frank Seela examines in his Stereochemistry study include Adduct, Glycosylation and Nucleic acid. His study in Oligonucleotide is interdisciplinary in nature, drawing from both Combinatorial chemistry, Side chain and Moiety.
Frank Seela has included themes like Crystallography, Duplex, Anomer, Metal and Phosphoramidite in his Base pair study. His DNA research is multidisciplinary, relying on both Antiparallel and Guanine. The study incorporates disciplines such as Residue, Substituent and Click chemistry in addition to Nucleobase.
Frank Seela mainly investigates DNA, Stereochemistry, Base pair, Oligonucleotide and Nucleobase. His work on Pyrimidine as part of general Stereochemistry study is frequently linked to Base Pair Mismatch, therefore connecting diverse disciplines of science. His Base pair research integrates issues from Crystallography, Antiparallel, Metal and Titration.
His Oligonucleotide research incorporates themes from Photochemistry, Moiety, Click chemistry and Pyrene. His research in Nucleobase intersects with topics in Nucleic acid, Covalent bond, Hoogsteen base pair, Phosphoramidite and Deprotonation. His Purine metabolism and Glycosylation study in the realm of Biochemistry interacts with subjects such as Dephosphorylation.
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1′, 5′ -Anhydrohexitol Oligonucleotides: Synthesis, Base Pairing and Recognition by Regular Oligodeoxyribonucleotides and Oligoribonucleotides
Chris Hendrix;Helmut Rosemeyer;Ilse Verheggen;Arthur Van Aerschot.
Chemistry: A European Journal (1997)
Modification of DNA with Octadiynyl Side Chains : Synthesis, Base Pairing, and Formation of Fluorescent Coumarin Dye Conjugates of Four Nucleobases by the Alkyne-Azide Click Reaction
Frank Seela;Venkata Ramana Sirivolu;Padmaja Chittepu.
Bioconjugate Chemistry (2008)
A Ratiometric Fluorescent On–Off Zn2+ Chemosensor Based on a Tripropargylamine Pyrene Azide Click Adduct
Sachin A. Ingale;Frank Seela;Frank Seela.
Journal of Organic Chemistry (2012)
Incorporation of a complete set of deoxyadenosine and thymidine analogues suitable for the study of protein nucleic acid interactions into oligodeoxynucleotides. Application to the EcoRV restriction endonuclease and modification methylase.
Patrick C. Newman;Victor U. Nwosu;David M. Williams;Richard Cosstick.
Duplex Stabilization of DNA: Oligonucleotides containing 7‐substituted 7‐deazaadenines
Frank Seela;Horst Thomas.
Helvetica Chimica Acta (1995)
"Double click" reaction on 7-deazaguanine DNA: synthesis and excimer fluorescence of nucleosides and oligonucleotides with branched side chains decorated with proximal pyrenes.
Frank Seela;Sachin A. Ingale.
Journal of Organic Chemistry (2010)
DNA Containing Side Chains with Terminal Triple Bonds: Base-Pair Stability and Functionalization of Alkynylated Pyrimidines and 7-Deazapurines
Frank Seela;Venkata Ramana Sirivolu.
Chemistry & Biodiversity (2006)
Nucleic acid binding compounds containing pyrazolo[3,4-d]pyrimidine analogues of purin-2,6-diamine and their uses
Frank Seela;Frank Bergmann;Herbert von der Eltz;Dieter Heindl.
1',5'-anhydrohexitol oligonucleotides: Hybridisation and strand displacement with oligoribonucleotides, interaction with RNase H and HIV reverse transcriptase
Chris Hendrix;Helmut Rosemeyer;Bart De Bouvere;Arthur Van Aerschot.
Chemistry: A European Journal (1997)
D-Altritol Nucleic Acids (ANA): Hybridisation Properties, Stability, and Initial Structural Analysis
Brigitte Allart;Kamran Khan;Helmut Rosemeyer;Guy Schepers.
Chemistry: A European Journal (1999)
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