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Leonid Beigelman

Leonid Beigelman

Overview

Leonid Beigelman is affiliated with Johnson & Johnson in the United States. Their research primarily spans across medicine, with significant contributions in biochemistry, genetics, and molecular biology. Beigelman's work is organized around key subfields such as epidemiology, molecular biology, hepatology, infectious diseases, and immunology.

The scientist has focused extensively on topics including Hepatitis B Virus studies, Hepatitis C virus research, SARS-CoV-2 and COVID-19 research, RNA interference and gene delivery, liver disease diagnosis and treatment, computational drug discovery methods, and interferon and immune responses.

Frequent publication venues for Beigelman's work include:

  • Journal of Hepatology
  • Antiviral Research
  • Regular and Young Investigator Award Abstracts
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Medicinal Chemistry

Beigelman has collaborated regularly with several researchers, including:

  • Lawrence M. Blatt
  • Julian Symons
  • Sushmita Chanda
  • Andreas Jekle
  • Antitsa Stoycheva

A selection of recent papers authored or co-authored by Beigelman includes:

  • The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir, 2023, mBio
  • Dual inhibition of SARS-CoV-2 and human rhinovirus with protease inhibitors in clinical development, 2021, Antiviral Research
  • The substitutions L50F, E166A and L167F in SARS-CoV-2 3CLpro are selected by a protease inhibitorin vitroand confer resistance to nirmatrelvir, 2022, bioRxiv (Cold Spring Harbor Laboratory)
  • Evaluation of SARS-CoV-2 3C-like protease inhibitors using self-assembled monolayer desorption ionization mass spectrometry, 2020, Antiviral Research
  • ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model, 2021, Biochemical and Biophysical Research Communications

Best Publications

  • 2'-deoxy-2'alkylnucleotide containing nucleic acid

    Nassim Usman;Alexander Karpeisky;Leonid Beigelman;Anil Modak

  • Synthesis, deprotection, analysis and purification of RNA and ribozymes

    Nassim Usman;Francine Wincott;David Sweedler;Leonid Beigelman

  • Novel compositions for the delivery of negatively charged molecules

    Leonid Beigelman;Jasenka Matulic-Adamic;Alexander Karpeisky;Peter Haeberli

  • Enzymatic nucleic acids containing 5'-and/or 3'-cap structures

    Jasenka Matulic-Adamic;Leonid Beigelman;Alexander Karpeisky;Thale Jarvis

  • Chemical Modification of Hammerhead Ribozymes: CATALYTIC ACTIVITY AND NUCLEASE RESISTANCE

    Leonid Beigelman;James A. McSwiggen;Kenneth G. Draper;Carolyn Gonzalez

  • Non-nucleotide containing enzymatic nucleic acid

    Nassim Usman;Francine Wincott;Jasenka Matulic-Adamic;Leonid Beigelman

  • 2'-O-alkylthioalkyl and 2'-c-alkylthioalkyl-containing nucleic acids

    Leonid Beigelman;Alex Karpeisky

  • THE STRUCTURAL BASIS OF HAMMERHEAD RIBOZYME SELF-CLEAVAGE

    James B Murray;Daniel P Terwey;Lara Maloney;Alexander Karpeisky

  • Comparison of the hammerhead cleavage reactions stimulated by monovalent and divalent cations.

    Jessica L. O'rear;Shenglong Wang;Andrew L. Feig;Leonid Beigelman

  • Synthesis of methoxy nucleosides and enzymatic nucleic acid molecules

    Francine Wincott;Nassim Usman;Leonid Beigelman;Peter Haeberli

  • Novel inhibitors of hepatitis c virus replication

    Leonid Beigelman;Guangyi Wang;Brad O. Buckman;Antitsa Dimitrova Stoycheva

  • Involvement of a specific metal ion in the transition of the hammerhead ribozyme to its catalytic conformation.

    Alessio Peracchi;Leonid Beigelman;Edmund C. Scott;Olke C. Uhlenbeck

  • Chemically Modified Hammerhead Ribozymes with Improved Catalytic Rates

    Alex B. Burgin;Carolyn Gonzalez;Jasenka Matulic-Adamic;Alexander M. Karpeisky

  • 2'-O-amino-containing nucleoside analogs and polynucleotides

    Alexander Karpeisky;Leonid Beigelman

  • Substituted nucleotide analogs

    David Bernard Smith;Jerome Deval;Natalia Dyatkina;Leonid Beigelman

  • Synthetic ribonucleic acids with RNAse activity

    Leonid Beigelman;Alex Burgin;Amber Beaudry;Alexander Karpeisky

  • The 2,6-diaminopurine riboside.5-methylisocytidine wobble base pair: an isoenergetic substitution for the study of G.U pairs in RNA.

    Scott A. Strobel;Thomas R. Cech;Nassim Usman;Leonid Beigelman

  • Ribozyme Catalysis from the Major Groove of Group II Intron Domain 5

    Boyana B Konforti;Dana L Abramovitz;Carlos M Duarte;Alex Karpeisky

  • Rescue of abasic hammerhead ribozymes by exogenous addition of specific bases

    Alessio Peracchi;Leonid Beigelman;Nassim Usman;Daniel Herschlag

  • Optimizing the Cell Efficacy of Synthetic Ribozymes SITE SELECTION AND CHEMICAL MODIFICATIONS OF RIBOZYMES TARGETING THE PROTO-ONCOGENE c-myb

    Thale C. Jarvis;Francine E. Wincott;Laverna J. Alby;James A. McSwiggen

Frequent Co-Authors

James McSwiggen
James McSwiggen Independent Scientist / Consultant, US
Harri Lönnberg
Harri Lönnberg University of Turku
Daniel Herschlag
Daniel Herschlag Stanford University
C. Cheng Kao
C. Cheng Kao Indiana University
Olke C. Uhlenbeck
Olke C. Uhlenbeck Northwestern University
Frank Seela
Frank Seela University of Münster
Anna Marie Pyle
Anna Marie Pyle Yale University
Peter G. Stockley
Peter G. Stockley University of Leeds
Martin Egli
Martin Egli Vanderbilt University
Arthur Pardi
Arthur Pardi University of Colorado Boulder

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