What is he best known for?
The fields of study he is best known for:
David Arnott mainly focuses on Cell biology, Ubiquitin, Biochemistry, Ubiquitin ligase and Molecular biology.
As a part of the same scientific study, David Arnott usually deals with the Cell biology, concentrating on Slit and frequently concerns with Axon guidance and Drosophila Protein.
His Deubiquitinating enzyme and Ubiquitin binding study, which is part of a larger body of work in Ubiquitin, is frequently linked to Domain mapping and Nf κb signaling, bridging the gap between disciplines.
His Biochemistry study combines topics from a wide range of disciplines, such as Myocyte, Muscle hypertrophy and Mass spectrometry.
His Ubiquitin ligase study combines topics in areas such as Deubiquitination, Transcription, Type I interferon production and Proteasome.
His Molecular biology research is multidisciplinary, incorporating perspectives in Phenotype, Polyacrylamide gel electrophoresis and Proteome.
His most cited work include:
- Slit Proteins Bind Robo Receptors and Have an Evolutionarily Conserved Role in Repulsive Axon Guidance (995 citations)
- The ubiquitin ligase COP1 is a critical negative regulator of p53. (607 citations)
- Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8. (459 citations)
What are the main themes of his work throughout his whole career to date?
David Arnott mostly deals with Molecular biology, Biochemistry, Cell biology, Mass spectrometry and Proteomics.
His research investigates the link between Molecular biology and topics such as Heterologous that cross with problems in Antibody.
The various areas that David Arnott examines in his Cell biology study include Chromatin, Histone H3 and Histone.
His work in Mass spectrometry tackles topics such as Peptide which are related to areas like Polyacrylamide gel electrophoresis.
His Proteomics research is multidisciplinary, relying on both Proteome, Bioinformatics and Edman degradation.
His work carried out in the field of Ubiquitin ligase brings together such families of science as Inhibitor of apoptosis, Transcription, Kinase and Proteasome.
He most often published in these fields:
- Molecular biology (25.26%)
- Biochemistry (25.26%)
- Cell biology (22.11%)
What were the highlights of his more recent work (between 2014-2020)?
- Cell biology (22.11%)
- Cancer research (11.58%)
- Histone H3 (8.42%)
In recent papers he was focusing on the following fields of study:
David Arnott focuses on Cell biology, Cancer research, Histone H3, Epigenetics and Histone.
His study in Cell biology focuses on Phosphorylation in particular.
His study in the field of Myeloid is also linked to topics like H3K4me3.
His work deals with themes such as T cell, Cell, E2F and Histone Demethylases, which intersect with Histone H3.
The study incorporates disciplines such as Epithelial–mesenchymal transition, Cancer, Proteomics and Cancer genome in addition to Epigenetics.
His Histone research includes themes of Enhancer, PI3K/AKT/mTOR pathway and Mass spectrometry.
Between 2014 and 2020, his most popular works were:
- An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells (145 citations)
- Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation. (96 citations)
- NLRP3 recruitment by NLRC4 during Salmonella infection. (76 citations)
In his most recent research, the most cited papers focused on:
David Arnott spends much of his time researching Histone H3, Cell biology, Chromatin, Cancer research and Innate immune system.
David Arnott has included themes like Cell culture, KDM5A and Histone Demethylases in his Histone H3 study.
His study in Cell biology is interdisciplinary in nature, drawing from both Enhancer, Transcription, Flagellin and Histone, Bromodomain.
The Chromatin study combines topics in areas such as Acetylation and CREB.
His research in Cancer research intersects with topics in Cancer cell, Regulation of gene expression and Immune system.
His Innate immune system research is multidisciplinary, incorporating elements of Pyroptosis, Caspase 1, NLRC4 and Signal transducing adaptor protein.
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