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David Arnott

David Arnott

D-Index & Metrics

Biology and Biochemistry

D-Index
51
Citations
12261
World Ranking
17008
National Ranking
7011

Overview

David Arnott is affiliated with Genentech in the United States, with a research focus situated primarily within the fields of Biochemistry, Genetics, and Molecular Biology. Their work emphasizes Molecular Biology and Cell Biology, with a total of nine publications contributing to these areas.

The research topics covered by Arnott include:

  • Histone Deacetylase Inhibitors Research
  • Protein Degradation and Inhibitors
  • Ubiquitin and proteasome pathways
  • Epigenetics and DNA Methylation
  • Cancer-related gene regulation
  • Advanced biosensing and bioanalysis techniques
  • Chemical Synthesis and Analysis

Arnott's recent publications span several notable journals and venues, indicating engagement with both experimental and analytical techniques in molecular and cellular biology. Recent papers include:

  • "Targeted degradation via direct 26S proteasome recruitment," 2022, published in Nature Chemical Biology
  • "Proteomic Analyses Identify a Novel Role for EZH2 in the Initiation of Cancer Cell Drug Tolerance," 2020, published in Journal of Proteome Research
  • "Large-scale single-molecule analysis of tau proteoforms," 2025, published as a preprint in bioRxiv (Cold Spring Harbor Laboratory)

Arnott frequently collaborates with a range of colleagues including Charlene Bashore, Sumit Prakash, Matthew C. Johnson, Ryan J. Conrad, and Ivy A. Kekessie. These collaborations reflect multi-disciplinary approaches common in molecular biology research.

The publication venues where Arnott's work appears include:

  • Nature Chemical Biology
  • Journal of Proteome Research
  • bioRxiv (Cold Spring Harbor Laboratory)

Best Publications

  • Slit Proteins Bind Robo Receptors and Have an Evolutionarily Conserved Role in Repulsive Axon Guidance

    Katja Brose;Kimberly S Bland;Kuan Hong Wang;David Arnott

  • The ubiquitin ligase COP1 is a critical negative regulator of p53.

    David Dornan;Ingrid Wertz;Ingrid Wertz;Harumi Shimizu;David Arnott

  • Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8.

    Frank C. Kischkel;David A. Lawrence;Antoine Tinel;Heidi LeBlanc

  • Biochemical Purification of a Mammalian Slit Protein as a Positive Regulator of Sensory Axon Elongation and Branching

    Kuan Hong Wang;Katja Brose;David Arnott;Thomas Kidd

  • DUBA: a deubiquitinase that regulates type I interferon production.

    Nobuhiko Kayagaki;Qui Phung;Salina Chan;Ruchir Chaudhari

  • Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase.

    Ingrid E. Wertz;Karen M. O'Rourke;Zemin Zhang;David Dornan

  • An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells

    Maia Vinogradova;Victor S Gehling;Amy Gustafson;Shilpi Arora

  • Phosphorylation of NLRC4 is critical for inflammasome activation

    Yan Qu;Shahram Misaghi;Anita Izrael-Tomasevic;Kim Newton

  • Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation.

    Ryan Raisner;Samir Kharbanda;Lingyan Jin;Edwin Jeng

  • Autophosphorylated CaMKIIα Acts as a Scaffold to Recruit Proteasomes to Dendritic Spines

    Baris Bingol;Baris Bingol;Chi-Fong Wang;David Arnott;Dongmei Cheng

  • Association of C-terminal ubiquitin hydrolase BRCA1-associated protein 1 with cell cycle regulator host cell factor 1.

    Shahram Misaghi;Søren Ottosen;Anita Izrael-Tomasevic;David Arnott

  • Ubiquitin Binding to A20 ZnF4 Is Required for Modulation of NF-κB Signaling

    Ivan Bosanac;Ingrid E. Wertz;Borlan Pan;Christine Yu

  • Repression of Stress-Induced LINE-1 Expression Protects Cancer Cell Subpopulations from Lethal Drug Exposure.

    Gulfem Dilek Guler;Charles Albert Tindell;Robert Pitti;Catherine Wilson

  • Silencing of retrotransposons by SETDB1 inhibits the interferon response in acute myeloid leukemia.

    Trinna L. Cuellar;Anna-Maria Herzner;Xiaotian Zhang;Yogesh Goyal

  • COP1 is a tumour suppressor that causes degradation of ETS transcription factors

    Alberto C. Vitari;Kevin G. Leong;Kim Newton;Cindy Yee

  • An Integrated Approach to Proteome Analysis: Identification of Proteins Associated with Cardiac Hypertrophy

    David Arnott;Kathy L. O'Connell;Kathleen L. King;John T. Stults

  • NLRP3 recruitment by NLRC4 during Salmonella infection.

    Yan Qu;Shahram Misaghi;Kim Newton;Allie Maltzman

  • Identification of longitudinally dynamic biomarkers in Alzheimer’s disease cerebrospinal fluid by targeted proteomics

    Kristin R Wildsmith;Stephen P Schauer;Ashley M Smith;David Arnott

  • Il-17 a/f heterologous polypeptides and therapeutic uses thereof

    David P. Arnott;Austin L. Gurney;Philip E. Hass;James M. Lee

  • Mass Spectrometric Contributions to the Practice of Phosphorylation Site Mapping through 2003 A Literature Review

    Kelly M. Loyet;John T. Stults;David Arnott

Frequent Co-Authors

James Lee
James Lee The Francis Crick Institute
Zora Modrusan
Zora Modrusan Genentech
Jinfeng Liu
Jinfeng Liu Genentech
Zemin Zhang
Zemin Zhang Peking University
Morgan Sheng
Morgan Sheng Broad Institute

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