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Karen O'Rourke

Karen O'Rourke

Genentech
United States

D-Index & Metrics

Discipline name D-Index World Ranking Current World Ranking National Ranking Current National Ranking Publications Citations
Biology and Biochemistry 47 18509 16978 7554 6734 53 37364

Karen O'Rourke publications per year

The chart shows the history of publications by Karen O'Rourke between 1985 and 2024, highlighting the no. of papers published in each year and offering an overview of the publication velocity of this scholar. Karen O'Rourke published across 40 years, from 1985 to 2024, averaging 1.4 papers a year. Output peaked at 6 publications in 1996. 2 of the 55 publications appeared in the last two years.

No. of publications
2 4 6
Bar chart. Horizontal axis: year, 1985 to 2024. Vertical axis: number of publications, 0 to 6. Peak 6 publications in 1996. 1985: 4 publications 1986: 1 publication 1987: 1 publication 1988: 2 publications 1989: 1 publication 1990: 1 publication 1991: 2 publications 1992: 2 publications 1993: 1 publication 1994: 2 publications 1995: 3 publications 1996: 6 publications 1997: 4 publications 1998: 3 publications 1999: 0 publications 2000: 1 publication 2001: 2 publications 2002: 0 publications 2003: 0 publications 2004: 4 publications 2005: 0 publications 2006: 2 publications 2007: 1 publication 2008: 0 publications 2009: 1 publication 2010: 3 publications 2011: 3 publications 2012: 0 publications 2013: 0 publications 2014: 0 publications 2015: 1 publication 2016: 0 publications 2017: 0 publications 2018: 0 publications 2019: 1 publication 2020: 0 publications 2021: 1 publication 2022: 0 publications 2023: 0 publications 2024: 2 publications
1985 2024

55 publications in total across all disciplines

View publications per year as a table
Karen O'Rourke: publications per year, 1985 to 2024
Year Publications
1985 4
1986 1
1987 1
1988 2
1989 1
1990 1
1991 2
1992 2
1993 1
1994 2
1995 3
1996 6
1997 4
1998 3
1999 0
2000 1
2001 2
2002 0
2003 0
2004 4
2005 0
2006 2
2007 1
2008 0
2009 1
2010 3
2011 3
2012 0
2013 0
2014 0
2015 1
2016 0
2017 0
2018 0
2019 1
2020 0
2021 1
2022 0
2023 0
2024 2
Total 55
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Karen O'Rourke publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Karen O'Rourke sits on this spectrum.

No. of scientists
200 400 600 800
Bar chart with 100 bars. Horizontal axis: publications, 47–56 to 1,028+. Vertical axis: number of scientists, 0 to 980. Most scientists, 980, have 127–136 publications. The last bar groups every scientist with 1,028 publications or more. The highlighted bar, 47–56 publications, is where this scientist sits. 47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 413 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 848 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 949 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 840 scientists 207–216 publications: 733 scientists 217–226 publications: 708 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 417 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 196 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 59 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientist 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientist 1,028+ publications: 100 scientists
47–56 publications 1,028+

This scientist: 53 publications — 1st percentile

1% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

View publications distribution as a table
Number of Biology and Biochemistry scientists by publication count, Research.com 2026 ranking edition. Based on 19,587 ranked scientists.
Publications Scientists This scientist
47–56 8 53
57–66 35
67–76 106
77–86 231
87–96 413
97–106 546
107–116 704
117–126 848
127–136 980
137–146 942
147–156 969
157–166 949
167–176 951
177–186 915
187–196 787
197–206 840
207–216 733
217–226 708
227–236 651
237–246 605
247–256 510
257–266 524
267–276 434
277–286 417
287–296 350
297–306 363
307–316 315
317–326 296
327–336 261
337–346 240
347–356 219
357–366 196
367–376 154
377–386 161
387–396 155
397–406 145
407–416 124
417–426 112
427–436 132
437–446 116
447–456 99
457–466 81
467–476 91
477–486 80
487–496 80
497–506 59
507–516 36
517–526 46
527–536 54
537–546 44
547–556 43
557–566 43
567–576 42
577–586 25
587–596 34
597–606 23
607–616 33
617–626 31
627–636 27
637–646 25
647–656 28
657–666 34
667–676 18
677–686 16
687–696 10
697–706 12
707–716 21
717–726 12
727–736 12
737–746 10
747–756 7
757–766 13
767–776 15
777–786 13
787–796 9
797–806 9
807–816 7
817–826 4
827–836 9
837–846 7
847–856 3
857–866 5
867–876 5
877–886 11
887–896 3
897–906 4
907–916 7
917–926 5
927–936 6
937–946 6
947–956 3
957–966 7
967–976 2
977–986 2
987–996 1
997–1,006 5
1,007–1,016 2
1,017–1,026 2
1,027 1
1,028+ 100
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Karen O'Rourke D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Karen O'Rourke sits on this spectrum.

No. of scientists
250 500 750 1,000 1,250
Bar chart with 65 bars. Horizontal axis: D-Index, 40–41 to 167+. Vertical axis: number of scientists, 0 to 1,253. Most scientists, 1,253, have 58–59 D-Index. The last bar groups every scientist with 167 D-Index or more. The highlighted bar, 46–47 D-Index, is where this scientist sits. 40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 316 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 899 scientists 52–53 D-Index: 1,025 scientists 54–55 D-Index: 1,149 scientists 56–57 D-Index: 1,235 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,162 scientists 62–63 D-Index: 1,130 scientists 64–65 D-Index: 1,031 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 714 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 71 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40–41 D-Index 167+

This scientist: 47 D-Index — 6th percentile

6% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

View D-Index distribution as a table
Number of Biology and Biochemistry scientists by D-index, Research.com 2026 ranking edition. Based on 19,587 ranked scientists.
D-Index Scientists This scientist
40–41 80
42–43 183
44–45 316
46–47 504 47
48–49 718
50–51 899
52–53 1,025
54–55 1,149
56–57 1,235
58–59 1,253
60–61 1,162
62–63 1,130
64–65 1,031
66–67 897
68–69 814
70–71 714
72–73 709
74–75 596
76–77 512
78–79 473
80–81 412
82–83 373
84–85 358
86–87 285
88–89 273
90–91 227
92–93 208
94–95 193
96–97 153
98–99 157
100–101 148
102–103 120
104–105 113
106–107 100
108–109 86
110–111 67
112–113 71
114–115 73
116–117 64
118–119 53
120–121 60
122–123 54
124–125 43
126–127 38
128–129 49
130–131 26
132–133 18
134–135 23
136–137 32
138–139 32
140–141 27
142–143 19
144–145 22
146–147 12
148–149 16
150–151 14
152–153 10
154–155 13
156–157 10
158–159 7
160–161 9
162–163 13
164–165 4
166 4
167+ 98
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Overview

Karen O'Rourke is affiliated with Genentech in the United States. Their research spans multiple fields including Biochemistry, Genetics and Molecular Biology, as well as Social Sciences. Their work integrates a range of specialized subfields such as Endocrinology, Epidemiology, Molecular Biology, Cultural Studies, and Anthropology.

Their academic output addresses several main topics of study, prominently:

  • Vibrio bacteria research studies
  • Autophagy in Disease and Therapy
  • Cell death mechanisms and regulation
  • Diverse Cultural and Historical Studies
  • Historical and Literary Studies
  • Historical and Literary Analyses

O'Rourke has authored papers appearing in notable venues, with frequent publications in:

  • Nouvelle revue d'esthétique (2 publications)
  • Nature (1 publication)

Their recent papers include:

  • "NINJ1 mediates plasma membrane rupture during lytic cell death," 2021, Nature
  • "Biographie établie par Jean Da Silva sur les indications de Karen O'Rourke," 2024, Nouvelle revue d'esthétique
  • "Tranche-montagne," 2024, Nouvelle revue d'esthétique

Karen O'Rourke's collaborations include coauthors frequently appearing alongside them such as Nobuhiko Kayagaki, Opher S. Kornfeld, Bettina L. Lee, Irma B. Stowe, and Qingling Li.

Best Publications

  • FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex.

    Marta Muzio;Arul M. Chinnaiyan;Frank C. Kischkel;Karen O'Rourke

  • Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

    Nobuhiko Kayagaki;Irma B. Stowe;Bettina L. Lee;Karen O’Rourke

  • Cryopyrin activates the inflammasome in response to toxins and ATP

    Sanjeev Mariathasan;David S. Weiss;Kim Newton;Jacqueline McBride

  • FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

    Arul M. Chinnaiyan;Karen O'Rourke;Muneesh Tewari;Vishva M. Dixit

  • Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

    Muneesh Tewari;Long T Quan;Karen O'Rourke;Serge Desnoyers

  • The receptor for the cytotoxic ligand TRAIL

    Guohua Pan;Karen O'Rourke;Arul M. Chinnaiyan;Reiner Gentz

  • De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling

    Ingrid E. Wertz;Karen M. O'Rourke;Honglin Zhou;Michael Eby

  • FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis.

    Arul M. Chinnaiyan;Clifford G. Tepper;Michael F. Seldin;Karen O'Rourke

  • Interaction of CED-4 with CED-3 and CED-9: A Molecular Framework for Cell Death

    Arul M. Chinnaiyan;Karen O'Rourke;Brian R. Lane;Vishva M. Dixit

  • The ubiquitin ligase COP1 is a critical negative regulator of p53.

    David Dornan;Ingrid Wertz;Ingrid Wertz;Harumi Shimizu;David Arnott

  • Signal Transduction by DR3, a Death Domain-Containing Receptor Related to TNFR-1 and CD95

    Arul M. Chinnaiyan;Karen O'Rourke;Guo Liang Yu;Robert H. Lyons

  • Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

    Ingrid E. Wertz;Saritha Kusam;Cynthia Lam;Toru Okamoto

  • Caspase-9, Bcl-XL, and Apaf-1 Form a Ternary Complex

    Guohua Pan;Karen O'Rourke;Vishva M. Dixit

  • Molecular ordering of the cell death pathway. Bcl-2 and Bcl-xL function upstream of the CED-3-like apoptotic proteases.

    Arul M. Chinnaiyan;Kim A Orth;Karen O'Rourke;Hangjun Duan

  • NINJ1 mediates plasma membrane rupture during lytic cell death

    Nobuhiko Kayagaki;Opher S. Kornfeld;Bettina L. Lee;Irma B. Stowe

  • Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

    Martin Schwickart;XiaoDong Huang;Jennie R. Lill;Jinfeng Liu

  • Bcl10 activates the NF-κB pathway through ubiquitination of NEMO

    Honglin Zhou;Ingrid Wertz;Ingrid Wertz;Karen O'Rourke;Mark Ultsch

  • Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis

    Jonathan W. Jones;Nobuhiko Kayagaki;Petr Broz;Thomas Henry

  • DUBA: a deubiquitinase that regulates type I interferon production.

    Nobuhiko Kayagaki;Qui Phung;Salina Chan;Ruchir Chaudhari

  • Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin.

    V M Dixit;S Green;V Sarma;L B Holzman

Frequent Co-Authors

Vishva M. Dixit
Vishva M. Dixit Genentech
Arul M. Chinnaiyan
Arul M. Chinnaiyan University of Michigan–Ann Arbor
Christopher C. Goodnow
Christopher C. Goodnow Garvan Institute of Medical Research
David Arnott
David Arnott Genentech
Somasekar Seshagiri
Somasekar Seshagiri Genentech
William A. Frazier
William A. Frazier Washington University in St. Louis
Guy S. Salvesen
Guy S. Salvesen Sanford Burnham Prebys Medical Discovery Institute
Samuel A. Santoro
Samuel A. Santoro Vanderbilt University
Jinfeng Liu
Jinfeng Liu Genentech
Gregory A. Grant
Gregory A. Grant Washington University in St. Louis

External Links

Personal website of Karen O'Rourke

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Best Scientists Citing Karen O'Rourke

Vishva M. Dixit

Vishva M. Dixit

Genentech

Publications: 172

Thirumala-Devi Kanneganti

Thirumala-Devi Kanneganti

St. Jude Children's Research Hospital

Publications: 107

John C. Reed

John C. Reed

Johnson & Johnson (United States)

Publications: 92

Gabriel Núñez

Gabriel Núñez

University of Michigan–Ann Arbor

Publications: 86

Douglas R. Green

Douglas R. Green

St. Jude Children's Research Hospital

Publications: 82

Peter Vandenabeele

Peter Vandenabeele

Ghent University

Publications: 81

Guy S. Salvesen

Guy S. Salvesen

Sanford Burnham Prebys Medical Discovery Institute

Publications: 81

Jürg Tschopp

Jürg Tschopp

University of Lausanne

Publications: 78

Andreas Strasser

Andreas Strasser

Walter and Eliza Hall Institute of Medical Research

Publications: 77

Henning Walczak

Henning Walczak

University College London

Publications: 75

Eicke Latz

Eicke Latz

German Rheumatism Research Centre

Publications: 74

Richard A. Flavell

Richard A. Flavell

Yale University

Publications: 68

Junying Yuan

Junying Yuan

Harvard University

Publications: 65

Peter H. Krammer

Peter H. Krammer

German Cancer Research Center

Publications: 64

Emad S. Alnemri

Emad S. Alnemri

Thomas Jefferson University

Publications: 64

Guido Kroemer

Guido Kroemer

Université Paris Cité

Publications: 64

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