Karen O'Rourke

Overview

Best Publications

• FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex.

  Marta Muzio;Arul M. Chinnaiyan;Frank C. Kischkel;Karen O'Rourke

  3914
  Citations

• Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

  Nobuhiko Kayagaki;Irma B. Stowe;Bettina L. Lee;Karen O’Rourke

  3679
  Citations

• Cryopyrin activates the inflammasome in response to toxins and ATP

  Sanjeev Mariathasan;David S. Weiss;Kim Newton;Jacqueline McBride

  3566
  Citations

• FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

  Arul M. Chinnaiyan;Karen O'Rourke;Muneesh Tewari;Vishva M. Dixit

  3392
  Citations

• Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

  Muneesh Tewari;Long T Quan;Karen O'Rourke;Serge Desnoyers

  3048
  Citations

• The receptor for the cytotoxic ligand TRAIL

  Guohua Pan;Karen O'Rourke;Arul M. Chinnaiyan;Reiner Gentz

  2394
  Citations

• De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling

  Ingrid E. Wertz;Karen M. O'Rourke;Honglin Zhou;Michael Eby

  2161
  Citations

• FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis.

  Arul M. Chinnaiyan;Clifford G. Tepper;Michael F. Seldin;Karen O'Rourke

  1049
  Citations

• Interaction of CED-4 with CED-3 and CED-9: A Molecular Framework for Cell Death

  Arul M. Chinnaiyan;Karen O'Rourke;Brian R. Lane;Vishva M. Dixit

  930
  Citations

• The ubiquitin ligase COP1 is a critical negative regulator of p53.

  David Dornan;Ingrid Wertz;Ingrid Wertz;Harumi Shimizu;David Arnott

  906
  Citations

• Signal Transduction by DR3, a Death Domain-Containing Receptor Related to TNFR-1 and CD95

  Arul M. Chinnaiyan;Karen O'Rourke;Guo Liang Yu;Robert H. Lyons

  865
  Citations

• Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

  Ingrid E. Wertz;Saritha Kusam;Cynthia Lam;Toru Okamoto

  847
  Citations

• Caspase-9, Bcl-XL, and Apaf-1 Form a Ternary Complex

  Guohua Pan;Karen O'Rourke;Vishva M. Dixit

  793
  Citations

• Molecular ordering of the cell death pathway. Bcl-2 and Bcl-xL function upstream of the CED-3-like apoptotic proteases.

  Arul M. Chinnaiyan;Kim A Orth;Karen O'Rourke;Hangjun Duan

  763
  Citations

• NINJ1 mediates plasma membrane rupture during lytic cell death

  Nobuhiko Kayagaki;Opher S. Kornfeld;Bettina L. Lee;Irma B. Stowe

  744
  Citations

• Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

  Martin Schwickart;XiaoDong Huang;Jennie R. Lill;Jinfeng Liu

  723
  Citations

• Bcl10 activates the NF-κB pathway through ubiquitination of NEMO

  Honglin Zhou;Ingrid Wertz;Ingrid Wertz;Karen O'Rourke;Mark Ultsch

  675
  Citations

• Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis

  Jonathan W. Jones;Nobuhiko Kayagaki;Petr Broz;Thomas Henry

  581
  Citations

• DUBA: a deubiquitinase that regulates type I interferon production.

  Nobuhiko Kayagaki;Qui Phung;Salina Chan;Ruchir Chaudhari

  519
  Citations

• Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin.

  V M Dixit;S Green;V Sarma;L B Holzman

  502
  Citations