World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
77
Citations
23272
World Ranking
4741
National Ranking
2296

Research.com Recognitions

  • 1945 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

William A. Frazier is affiliated with Washington University in St. Louis in the United States. Their research spans multiple fields primarily within Physics and Astronomy as well as Medicine. The scientist's work includes contributions to subfields such as Astronomy and Astrophysics, Aerospace Engineering, Instrumentation, Atmospheric Science, and Immunology.

The main topics covered in their research include:

  • Astro and Planetary Science
  • Space Exploration and Technology
  • Astronomy and Astrophysical Research
  • Planetary Science and Exploration
  • Atmospheric Ozone and Climate
  • Stellar, planetary, and galactic studies
  • T-cell and Retrovirus Studies

Frequent collaborators in their research include Steven Jacobson, D. R. Ardila, Evgenya L. Shkolnik, John Ziemer, and Mark G. Swain.

William A. Frazier's recent papers reflect a spread across astrophysical and medical research topics. Notable publications are:

  • The UV-SCOPE mission: ultraviolet spectroscopic characterization of planets and their environments (2022) - Space Telescopes and Instrumentation 2022: Ultraviolet to Gamma Ray
  • The UV-SCOPE Mission: Ultraviolet Spectroscopic Characterization Of Planets and their Environments (2022) - arXiv (Cornell University)
  • Radiological Changes in Spinal Cord and Brain of Patients with HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) (2024) - Preprints.org
  • Broad-spectrum antiviral brincidofovir inhibits Epstein-Barr virus and related gammaherpesvirus in human and nonhuman primate cells (2025) - Journal of Clinical Investigation

The scientist has published in venues including:

  • Space Telescopes and Instrumentation 2022: Ultraviolet to Gamma Ray
  • arXiv (Cornell University)
  • Preprints.org
  • Journal of Clinical Investigation

Their work reflects intersections between observational astrophysics and medical virology, indicating a breadth of scientific inquiry. William A. Frazier was recognized as a Fellow of the American Association for the Advancement of Science (AAAS) in 1945.

Best Publications

  • CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

    Cameron R Stewart;Lynda M Stuart;Kim Wilkinson;Janine M van Gils

  • A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin

    D J Good;P J Polverini;F Rastinejad;M M Le Beau

  • Integrin-associated protein (CD47) and its ligands

    Eric J. Brown;William A. Frazier

  • CD36 Mediates the In Vitro Inhibitory Effects of Thrombospondin-1 on Endothelial Cells

    David W. Dawson;S. Frieda A. Pearce;Ruiqin Zhong;Roy L. Silverstein

  • Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-angiogenic activity

    Sara S. Tolsma;Olga V. Volpert;Deborah J. Good;William A. Frazier

  • CD47 blockade triggers T cell–mediated destruction of immunogenic tumors

    Xiaojuan Liu;Yang Pu;Kyle Cron;Liufu Deng

  • Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species

    Eugene A. Podrez;Maria Febbraio;Nader Sheibani;David Schmitt

  • Integrin-associated Protein Is a Receptor for the C-terminal Domain of Thrombospondin

    Ai-Guo Gao;Frederik P. Lindberg;Mary Beth Finn;Scott D. Blystone

  • Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis

    Masako Kohyama;Wataru Ise;Brian T. Edelson;Peter R. Wilker

  • Transfection of Thrombospondin 1 Complementary DNA into a Human Breast Carcinoma Cell Line Reduces Primary Tumor Growth, Metastatic Potential, and Angiogenesis

    Debra L. Weinstat-Saslow;Vivian S. Zabrenetzky;Kenneth VanHoutte;William A. Frazier

  • Thrombospondin binds falciparum malaria parasitized erythrocytes and may mediate cytoadherence.

    David D. Roberts;James A. Sherwood;Steven L. Spitalnik;Lindsey J. Panton

  • Nerve Growth Factor

    Linda F. Boyd;Ralph A. Bradshaw;William A. Frazier;Ruth A. Hogue-Angeletti

  • Nerve Growth Factor and Insulin

    William A. Frazier;Ruth Hogue Angeletti;Ralph A. Bradshaw

  • CD47, a Ligand for the Macrophage Fusion Receptor, Participates in Macrophage Multinucleation

    Xin Han;Hyacinth Sterling;Yongmei Chen;Charles Saginario

  • CD47 Is Necessary for Inhibition of Nitric Oxide-stimulated Vascular Cell Responses by Thrombospondin-1

    Jeff S. Isenberg;Lisa A. Ridnour;Julie Dimitry;William A. Frazier

  • Thrombospondin modulates alpha v beta 3 function through integrin-associated protein.

    A G Gao;F P Lindberg;J M Dimitry;E J Brown

  • The properdin-like type I repeats of human thrombospondin contain a cell attachment site.

    C A Prater;J Plotkin;D Jaye;W A Frazier

  • Thrombspondin Acts via Integrin-associated Protein to Activate the Platelet Integrin αIIbβ3

    Jun Chung;Ai-Guo Gao;William A. Frazier

  • Thrombospondin: a modular adhesive glycoprotein of platelets and nucleated cells.

    William A. Frazier

  • Thrombospondin-1 stimulates platelet aggregation by blocking the antithrombotic activity of nitric oxide/cGMP signaling.

    Jeff S. Isenberg;Martin J. Romeo;Christine Yu;Christine K. Yu

Frequent Co-Authors

David D. Roberts
David D. Roberts National Institutes of Health
Ralph A. Bradshaw
Ralph A. Bradshaw University of California, Irvine
Nader Sheibani
Nader Sheibani University of Wisconsin–Madison
Samuel A. Santoro
Samuel A. Santoro Vanderbilt University
Gregory A. Grant
Gregory A. Grant Washington University in St. Louis
William C. Chapman
William C. Chapman Washington University in St. Louis
Mones Abu-Asab
Mones Abu-Asab National Institutes of Health
Eric J. Brown
Eric J. Brown University of Pennsylvania
Noel P. Bouck
Noel P. Bouck Northwestern University

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