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D-Index & Metrics

Biology and Biochemistry

D-Index
117
Citations
49412
World Ranking
722
National Ranking
459

Overview

Eric J. Brown is affiliated with the University of Pennsylvania in the United States and conducts research primarily within the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their work spans several key subfields including Molecular Biology, Oncology, Genetics, Cancer Research, and Immunology.

The scientist's research focuses on topics related to DNA Repair Mechanisms, PARP inhibition in cancer therapy, BRCA gene mutations in cancer, interferon and immune responses, Chromatin Remodeling and Cancer, Protein Degradation and Inhibitors, and CRISPR and Genetic Engineering.

Frequent publication venues for Eric J. Brown include Cancer Research, Molecular Cancer Therapeutics, European Journal of Cancer, Gynecologic Oncology, and Nature Communications.

Notable recent papers include:

  • Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models, 2020, Nature Communications
  • Once daily oral relugolix combination therapy versus placebo in patients with endometriosis-associated pain: two replicate phase 3, randomised, double-blind, studies (SPIRIT 1 and 2), 2022, The Lancet
  • CCNE1 copy number is a biomarker for response to combination WEE1-ATR inhibition in ovarian and endometrial cancer models, 2021, Cell Reports Medicine
  • Combination ATR (ceralasertib) and PARP (olaparib) Inhibitor (CAPRI) Trial in Acquired PARP Inhibitor-Resistant Homologous Recombination-Deficient Ovarian Cancer, 2023, Clinical Cancer Research
  • G6PD-mediated increase in de novo NADP+ biosynthesis promotes antioxidant defense and tumor metastasis, 2022, Science Advances

Frequent co-authors collaborating with Eric J. Brown include Fiona Simpkins, Erin George, Oren Gilad, Hyoung Kim, and Haineng Xu.

Best Publications

  • A mammalian protein targeted by G1-arresting rapamycin–receptor complex

    Eric J. Brown;Mark W. Albers;Tae Bum Shin;Kazuo ichikawa

  • Germline Transmission and Tissue-Specific Expression of Transgenes Delivered by Lentiviral Vectors

    Carlos Lois;Elizabeth J. Hong;Shirley Pease;Eric J. Brown

  • The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor

    Stephan Gasser;Sandra Orsulic;Eric J. Brown;David H. Raulet

  • ATR disruption leads to chromosomal fragmentation and early embryonic lethality.

    Eric J. Brown;David Baltimore

  • Integrin-associated protein (CD47) and its ligands

    Eric J. Brown;William A. Frazier

  • Epithelial to Mesenchymal Transition Is a Determinant of Sensitivity of Non–Small-Cell Lung Carcinoma Cell Lines and Xenografts to Epidermal Growth Factor Receptor Inhibition

    Stuart Thomson;Elizabeth Buck;Filippo Petti;Graeme Griffin

  • Control of p70 S6 kinase by kinase activity of FRAP in vivo

    Eric J. Brown;Peter A. Beal;Curtis T. Keith;Jie Chen

  • Decreased resistance to bacterial infection and granulocyte defects in IAP-deficient mice

    Frederik P. Lindberg;Daniel C. Bullard;Tony E. Caver;Hattie D. Gresham

  • Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue

    Jie Chen;Xiao Feng Zheng;Eric J. Brown;Stuart L. Schreiber

  • Deletion of the Developmentally Essential Gene ATR in Adult Mice Leads to Age-Related Phenotypes and Stem Cell Loss

    Yaroslava Ruzankina;Carolina Pinzon-Guzman;Amma Asare;Tony Ong

  • Novel antibody–antibiotic conjugate eliminates intracellular S. aureus

    Sophie M. Lehar;Thomas Pillow;Min Xu;Leanna Staben

  • Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance

    Eric J. Brown;David Baltimore

  • Disruption of the Mouse mTOR Gene Leads to Early Postimplantation Lethality and Prohibits Embryonic Stem Cell Development

    Yann-Gaël Gangloff;Matthias Mueller;Stephen G. Dann;Petr Svoboda

  • INTEGRIN-ASSOCIATED PROTEIN : A 50-KD PLASMA MEMBRANE ANTIGEN PHYSICALLY AND FUNCTIONALLY ASSOCIATED WITH INTEGRINS

    Eric Brown;Lora Hooper;Thang Ho;Hattie Gresham

  • Integrin-associated Protein Is a Receptor for the C-terminal Domain of Thrombospondin

    Ai-Guo Gao;Frederik P. Lindberg;Mary Beth Finn;Scott D. Blystone

  • Molecular cloning of integrin-associated protein: an immunoglobulin family member with multiple membrane-spanning domains implicated in alpha v beta 3-dependent ligand binding.

    Frederik P. Lindberg;Hattie D. Gresham;Elsa Schwarz;Eric J. Brown

  • A Signaling Pathway to Translational Control

    Eric J Brown;Stuart L Schreiber

  • Acute postnatal ablation of Hif-2α results in anemia

    Michaela Gruber;Cheng-Jun Hu;Randall S. Johnson;Eric J. Brown

  • A mycobacterial virulence gene cluster extending RD1 is required for cytolysis, bacterial spreading and ESAT-6 secretion

    Lian-Yong Gao;Su Guo;Bryant McLaughlin;Hiroshi Morisaki

  • Adhesion-activating phorbol ester increases the mobility of leukocyte integrin LFA-1 in cultured lymphocytes.

    D F Kucik;M L Dustin;J M Miller;E J Brown

Frequent Co-Authors

Timothy L. Ratliff
Timothy L. Ratliff Purdue University West Lafayette
William A. Frazier
William A. Frazier Washington University in St. Louis
Paul M. Allen
Paul M. Allen Washington University in St. Louis
Ira D. Goldfine
Ira D. Goldfine University of California, San Francisco
Carlos Rosales
Carlos Rosales National Autonomous University of Mexico
Axel Ullrich
Axel Ullrich Max Planck Institute of Biochemistry
John F. Bohnsack
John F. Bohnsack University of Utah

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