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Sanjeev Mariathasan

Sanjeev Mariathasan

D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
38770
World Ranking
12869
National Ranking
5475

Overview

Sanjeev Mariathasan is affiliated with Genentech in the United States and has a research focus primarily situated in the fields of Medicine and Immunology and Microbiology. Their work extensively covers oncology, immunology, surgery, and pulmonary and respiratory medicine, with significant contributions to cancer research.

The scientist's research centers on several main topics:

  • Cancer Immunotherapy and Biomarkers
  • Bladder and Urothelial Cancer Treatments
  • Immune Cell Function and Interaction
  • Urinary and Genital Oncology Studies
  • Cancer Genomics and Diagnostics
  • Immune cells in cancer
  • Prostate Cancer Treatment and Research

Some of their most cited recent papers include:

  • "Atezolizumab with or without chemotherapy in metastatic urothelial cancer (IMvigor130): a multicentre, randomised, placebo-controlled phase 3 trial" (2020) published in The Lancet
  • "Peripheral T cell expansion predicts tumour infiltration and clinical response" (2020) published in Nature
  • "ctDNA guiding adjuvant immunotherapy in urothelial carcinoma" (2021) published in Nature
  • "Molecular Subsets in Renal Cancer Determine Outcome to Checkpoint and Angiogenesis Blockade" (2020) published in Cancer Cell
  • "High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade" (2020) published in Nature Medicine

The scientist has frequently published in high-impact journals. Notable publication venues include:

  • Journal of Clinical Oncology
  • Cancer Research
  • Nature
  • Nature Medicine
  • Cancer Immunology Research

Collaborations are a significant part of their research, with frequent coauthors including:

  • Romain Banchereau
  • Thomas Powles
  • Kobe Yuen
  • Ira Mellman
  • Edward E. Kadel

Best Publications

  • TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells.

    Sanjeev Mariathasan;Shannon J. Turley;Dorothee Nickles;Alessandra Castiglioni

  • Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: A single-arm, multicentre, phase 2 trial

    Jonathan E Rosenberg;Jean Hoffman-Censits;Tom Powles;Michiel S van der Heijden

  • Cryopyrin activates the inflammasome in response to toxins and ATP

    Sanjeev Mariathasan;David S. Weiss;Kim Newton;Jacqueline McBride

  • Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf.

    Sanjeev Mariathasan;Kim Newton;Denise M. Monack;Domagoj Vucic

  • Atezolizumab versus chemotherapy in patients with platinum-treated locally advanced or metastatic urothelial carcinoma (IMvigor211): a multicentre, open-label, phase 3 randomised controlled trial.

    Thomas Powles;Ignacio Durán;Michiel S van der Heijden;Yohann Loriot

  • Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin

    Pietro De Togni;Joseph Goellner;Nancy H. Ruddle;Philip R. Streeter

  • Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation.

    Sanjeev Mariathasan;Denise M. Monack

  • Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

    Kurt Wolfgang Bachmaier;Connie Krawczyk;Ivona Kozieradzki;Young Yun Kong

  • Novel antibody–antibiotic conjugate eliminates intracellular S. aureus

    Sophie M. Lehar;Thomas Pillow;Min Xu;Leanna Staben

  • Peripheral T cell expansion predicts tumour infiltration and clinical response

    Thomas D. Wu;Shravan Madireddi;Patricia E. de Almeida;Romain Banchereau

  • SELECTION OF THE T CELL REPERTOIRE

    Eric Sebzda;Sanjeev Mariathasan;Toshiaki Ohteki;Russell Jones

  • Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella

    Petr Broz;Kim Newton;Mohamed Lamkanfi;Sanjeev Mariathasan

  • Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2.

    H Molina;V M Holers;B Li;Y Fung

  • The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection.

    Dario S Zamboni;Koichi S Kobayashi;Koichi S Kobayashi;Tiana Kohlsdorf;Yasunori Ogura

  • Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis

    Sanjeev Mariathasan;David S. Weiss;Vishva M. Dixit;Denise M. Monack

  • Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers.

    Mitsuru Matsumoto;Sanjeev Mariathasan;Moon H. Nahm;Ferenc Baranyay

  • Clinical efficacy and biomarker analysis of neoadjuvant atezolizumab in operable urothelial carcinoma in the ABACUS trial.

    Thomas Powles;Mark Kockx;Alejo Rodriguez-Vida;Ignacio Duran

  • A NOD2-NALP1 complex mediates caspase-1-dependent IL-1β secretion in response to Bacillus anthracis infection and muramyl dipeptide

    Li Chung Hsu;Syed R. Ali;Shauna McGillivray;Ping Hui Tseng

  • ctDNA guiding adjuvant immunotherapy in urothelial carcinoma.

    Thomas Powles;Zoe June Assaf;Nicole Davarpanah;Romain Banchereau

  • Molecular Subsets in Renal Cancer Determine Outcome to Checkpoint and Angiogenesis Blockade

    Robert J. Motzer;Romain Banchereau;Habib Hamidi;Thomas Powles

Frequent Co-Authors

Thomas Powles
Thomas Powles Queen Mary University of London
Priti Hegde
Priti Hegde Genentech
Jonathan E. Rosenberg
Jonathan E. Rosenberg Memorial Sloan Kettering Cancer Center
Pamela S. Ohashi
Pamela S. Ohashi Princess Margaret Cancer Centre
Joaquim Bellmunt
Joaquim Bellmunt Beth Israel Deaconess Medical Center
Ira Mellman
Ira Mellman Parker Institute for Cancer Immunotherapy
David D. Chaplin
David D. Chaplin University of Alabama at Birmingham
Ian D. Davis
Ian D. Davis Monash University

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