Jürg Tschopp

Research.com Recognitions

• 2025 - Research.com Best Scientists Award
• 2023 - Research.com Biology and Biochemistry in Switzerland Leader Award
• 2022 - Research.com Biology and Biochemistry in Switzerland Leader Award
• 2009 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Best Publications

• The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.

  Fabio Martinon;Kimberly Burns;Jürg Tschopp

  6518
  Citations

• Gout-associated uric acid crystals activate the NALP3 inflammasome

  Fabio Martinon;Virginie Pétrilli;Annick Mayor;Aubry Tardivel

  5752
  Citations

• A role for mitochondria in NLRP3 inflammasome activation

  Rongbin Zhou;Amir S. Yazdi;Philippe Menu;Jürg Tschopp

  5180
  Citations

• Inhibition of death receptor signals by cellular FLIP

  Martin Irmler;Margot Thome;Michael Hahne;Pascal Schneider

  3429
  Citations

• Induction of TNF Receptor I-Mediated Apoptosis via Two Sequential Signaling Complexes

  Olivier Micheau;Jürg Tschopp

  3289
  Citations

• Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

  Etienne Meylan;Joseph Curran;Kay Hofmann;Darius Moradpour

  2958
  Citations

• Thioredoxin-interacting protein links oxidative stress to inflammasome activation

  Rongbin Zhou;Aubry Tardivel;Bernard Thorens;Inpyo Choi

  2804
  Citations

• Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule.

  Nils Holler;Rossana Zaru;Olivier Micheau;Margot Thome

  2295
  Citations

• NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder

  Laetitia Agostini;Fabio Martinon;Kimberly Burns;Michael F. McDermott

  2104
  Citations

• Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

  François Ghiringhelli;Lionel Apetoh;Antoine Tesniere;Antoine Tesniere;Antoine Tesniere;Laetitia Aymeric;Laetitia Aymeric;Laetitia Aymeric

  2102
  Citations

• NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?

  Jurg Tschopp;Kate Schroder;Kate Schroder

  1909
  Citations

• Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations.

  Fabienne Mackay;Stephen A. Woodcock;Pornsri Lawton;Christine Ambrose

  1826
  Citations

• Intracellular pattern recognition receptors in the host response

  Etienne Meylan;Jürg Tschopp;Michael Karin

  1707
  Citations

• BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth.

  Pascal Schneider;Fabienne Mackay;Véronique Steiner;Kay Hofmann

  1700
  Citations

• Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

  Margot Thome;Pascal Schneider;Kay Hofmann;Helmut Fickenscher

  1691
  Citations

• Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways

  Bente Lowin;Michael Hahne;Chantal Mattmann;Jürg Tschopp

  1519
  Citations

• Inhibition of toxic epidermal necrolysis by blockade of CD95 with human intravenous immunoglobulin.

  Isabelle Viard;Philippe Wehrli;Roberto Bullani;Pascal Schneider

  1363
  Citations

• The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

  Kate Schroder;Rongbin Zhou;Jurg Tschopp

  1215
  Citations

• Inflammatory Caspases: Linking an Intracellular Innate Immune System to Autoinflammatory Diseases

  Fabio Martinon;Jürg Tschopp

  1206
  Citations

• The molecular architecture of the TNF superfamily

  Jean-Luc Bodmer;Pascal Schneider;Jürg Tschopp

  1193
  Citations