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Biology and Biochemistry
Germany
2023

D-Index & Metrics

Genetics

D-Index
116
Citations
59885
World Ranking
441
National Ranking
28

Molecular Biology

D-Index
116
Citations
59885
World Ranking
294
National Ranking
26

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Germany Leader Award

Overview

Kay Hofmann is affiliated with the University of Cologne in Germany. Their research primarily falls within the fields of Biochemistry, Genetics, and Molecular Biology, with a concentration on Molecular Biology, Cell Biology, Oncology, Epidemiology, and Immunology.

The scientist has contributed extensively to several research topics, including:

  • Ubiquitin and proteasome pathways
  • Glycosylation and glycoproteins research
  • Endoplasmic reticulum stress and disease
  • RNA modifications and cancer
  • Peptidase inhibition and analysis
  • Autophagy in disease and therapy
  • Mitochondrial function and pathology

Kay Hofmann has published numerous papers across a range of scientific journals. Notable recent publications include:

  • Discovery of a Family of Mixed Lineage Kinase Domain-like Proteins in Plants and Their Role in Innate Immune Signaling, 2020, Cell Host & Microbe
  • Identification and characterization of diverse OTU deubiquitinases in bacteria, 2020, The EMBO Journal
  • Bacterial ribosome collision sensing by a MutS DNA repair ATPase paralogue, 2022, Nature
  • Proteasomal degradation induced by DPP9-mediated processing competes with mitochondrial protein import, 2020, The EMBO Journal
  • Cytoplasmic calcium influx mediated by plant MLKLs confers TNL-triggered immunity, 2024, Cell Host & Microbe

The preferred venues for publication by Hofmann reflect their research focus and include the following journals where they have multiple contributions:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Life Science Alliance
  • Journal of Cell Science
  • Cell Host & Microbe

Over the course of their career, Hofmann has frequently collaborated with several co-authors, notably:

  • Thomas Hermanns
  • Ulrich Baumann
  • Matthias Uthoff
  • Martin Grønbæk-Thygesen
  • Caroline Kampmeyer

Best Publications

  • Inhibition of death receptor signals by cellular FLIP

    Martin Irmler;Margot Thome;Michael Hahne;Pascal Schneider

  • Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

    Etienne Meylan;Joseph Curran;Kay Hofmann;Darius Moradpour

  • Tmbase-A database of membrane spanning protein segments

    K Hofmann;W Stoffel

  • SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box.

    Chang Bai;Partha Sen;Kay Hofmann;Lei Ma

  • The PROSITE database, its status in 1997

    Amos Marc Bairoch;Philip Bucher;Kay Hofmann

  • BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth.

    Pascal Schneider;Fabienne Mackay;Véronique Steiner;Kay Hofmann

  • Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

    Margot Thome;Pascal Schneider;Kay Hofmann;Helmut Fickenscher

  • The PROSITE database, its status in 1999.

    Kay Hofmann;Philip Bucher;Laurent Falquet;Amos Marc Bairoch

  • The PROSITE database, its status in 2002.

    Laurent Falquet;Marco Pagni;Philipp Bucher;Nicolas Hulo

  • RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation.

    Etienne Meylan;Kim Burns;Kay Hofmann;Vincent Blancheteau

  • A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins.

    Peer Bork;Kay Hofmann;Philipp Bucher;Andrew F. Neuwald

  • Arac/XylS family of transcriptional regulators.

    M T Gallegos;R Schleif;A Bairoch;K Hofmann

  • TRAIL Receptors 1 (DR4) and 2 (DR5) Signal FADD-Dependent Apoptosis and Activate NF-κB

    Pascal Schneider;Margot Thome;Kim Burns;Jean-Luc Bodmer

  • Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis.

    Marzena Bienko;Catherine M. Green;Nicola Crosetto;Fabian Rudolf

  • Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion

    Yun Wang;Masaya Okamoto;Frank Schmitz;Kay Hofmann

  • Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair.

    Agata Smogorzewska;Agata Smogorzewska;Shuhei Matsuoka;Patrizia Vinciguerra;E. Robert McDonald

  • Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65.

    Agne Kazlauskaite;Chandana Kondapalli;Robert Gourlay;David G. Campbell

  • Proteasome subunit Rpn13 is a novel ubiquitin receptor

    Koraljka Husnjak;Suzanne Elsasser;Naixia Zhang;Xiang Chen

  • APRIL, a New Ligand of the Tumor Necrosis Factor Family, Stimulates Tumor Cell Growth

    Michael Hahne;Takao Kataoka;Michael Schröter;Kay Hofmann

  • Selective autophagy: ubiquitin-mediated recognition and beyond

    Claudine Kraft;Matthias Peter;Kay Hofmann

Frequent Co-Authors

Jürg Tschopp
Jürg Tschopp University of Lausanne
Philipp Bucher
Philipp Bucher École Polytechnique Fédérale de Lausanne
Matthias Peter
Matthias Peter ETH Zurich
Pascal Schneider
Pascal Schneider University of Lausanne
Wilhelm Stoffel
Wilhelm Stoffel University of Cologne
David Komander
David Komander Walter and Eliza Hall Institute of Medical Research
Ivan Dikic
Ivan Dikic Goethe University Frankfurt
Margot Thome
Margot Thome University of Lausanne
Michael Hahne
Michael Hahne Centre national de la recherche scientifique, CNRS
Christian Kubisch
Christian Kubisch Universität Hamburg

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