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Molecular Biology
USA
2026

D-Index & Metrics

Molecular Biology

D-Index
148
Citations
119307
World Ranking
88
National Ranking
56

Biology and Biochemistry

D-Index
150
Citations
120947
World Ranking
177
National Ranking
124

Research.com Recognitions

  • 2026 - Research.com Molecular Biology in United States Leader Award
  • 2018 - Fellow of the American Academy of Arts and Sciences
  • 2013 - Fellow of the American Society of Plant Biologists
  • 2012 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1999 - American Dairy Science Association Fellowship Award
  • 1975 - Fellow of the Royal Society of Canada

Overview

J. Wade Harper is affiliated with Harvard University in the United States. Their research spans key areas within biochemistry, genetics, and molecular biology, with significant contributions to medicine. They have a strong focus on molecular biology, cell biology, epidemiology, physiology, and neurology.

The primary themes in Harper's work include autophagy in disease and therapy, ubiquitin and proteasome pathways, cellular transport and secretion, mitochondrial function and pathology, endoplasmic reticulum stress and disease, RNA and protein synthesis mechanisms, and lysosomal storage disorders research.

Harper has published extensively in venues such as bioRxiv (Cold Spring Harbor Laboratory), Zenodo (CERN European Organization for Nuclear Research), Nature, Nature Communications, and the Proceedings of the National Academy of Sciences.

  • bioRxiv (Cold Spring Harbor Laboratory): 25 publications
  • Zenodo (CERN European Organization for Nuclear Research): 12 publications
  • Nature: 8 publications
  • Nature Communications: 6 publications
  • Proceedings of the National Academy of Sciences: 5 publications

Frequent co-authors include:

  • João A. Paulo (49 joint publications)
  • Alban Ordureau (24 joint publications)
  • Steven P. Gygi (20 joint publications)
  • Sharan Swarup (19 joint publications)
  • Brenda A. Schulman (17 joint publications)

Among recent papers authored or co-authored by Harper are:

  • "Dual proteome-scale networks reveal cell-specific remodeling of the human interactome," 2021, Cell
  • "Cullin-RING Ubiquitin Ligase Regulatory Circuits: A Quarter Century Beyond the F-Box Hypothesis," 2021, Annual Review of Biochemistry
  • "Global Landscape and Dynamics of Parkin and USP30-Dependent Ubiquitylomes in iNeurons during Mitophagic Signaling," 2020, Molecular Cell
  • "EDF1 coordinates cellular responses to ribosome collisions," 2020, eLife
  • "Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy," 2021, eLife

Harper was named a Fellow of the American Academy of Arts and Sciences in 2018.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

    J. Wade Harper;Guy R. Adami;Nan Wei;Khandan Keyomarsi

  • Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

    Chuxia Deng;Chuxia Deng;Pumin Zhang;J. Wade Harper;Stephen J. Elledge;Stephen J. Elledge

  • A Map of the Interactome Network of the Metazoan C. elegans

    Siming Li;Christopher M. Armstrong;Nicolas Bertin;Hui Ge

  • The DNA Damage Response: Ten Years After

    J. Wade Harper;Stephen J. Elledge;Stephen J. Elledge;Stephen J. Elledge

  • p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

    Vjekoslav Dulić;William K. Kaufmann;William K. Kaufmann;Sandra J. Wilson;Sandra J. Wilson;Thea D. Tisty;Thea D. Tisty

  • SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box.

    Chang Bai;Partha Sen;Kay Hofmann;Lei Ma

  • Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

    Joseph D. Mancias;Xiaoxu Wang;Steven P. Gygi;J. Wade Harper

  • Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome

    Woong Kim;Eric J. Bennett;Edward L. Huttlin;Ailan Guo

  • Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.

    Ning Zheng;Brenda A. Schulman;Brenda A. Schulman;Langzhou Song;Julie J. Miller

  • Network organization of the human autophagy system

    Christian Behrends;Mathew E. Sowa;Steven P. Gygi;J. Wade Harper

  • Molecular definitions of autophagy and related processes

    Lorenzo Galluzzi;Lorenzo Galluzzi;Eric H. Baehrecke;Andrea Ballabio;Patricia Boya

  • Defining the Human Deubiquitinating Enzyme Interaction Landscape

    Mathew E. Sowa;Eric J. Bennett;Steven P. Gygi;J. Wade Harper

  • F-Box Proteins Are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin-Ligase Complex

    Dorota Skowyra;Karen L Craig;Mike Tyers;Stephen J Elledge

  • Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle

    Koff A;Giordano A;Desai D;Yamashita K

  • The BioPlex Network: A Systematic Exploration of the Human Interactome

    Edward L. Huttlin;Lily Ting;Raphael J. Bruckner;Fana Gebreab

  • Architecture of the human interactome defines protein communities and disease networks

    Edward L. Huttlin;Raphael J. Bruckner;Joao A. Paulo;Joe R. Cannon

  • Inhibition of cyclin-dependent kinases by p21.

    J W Harper;S J Elledge;K Keyomarsi;B Dynlacht

  • p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.

    S Matsuoka;M C Edwards;C Bai;S Parker

Frequent Co-Authors

Stephen J. Elledge
Stephen J. Elledge Harvard University
Steven P. Gygi
Steven P. Gygi Harvard University
Joao A. Paulo
Joao A. Paulo Harvard University
Mathew E. Sowa
Mathew E. Sowa Harvard University
Brenda A. Schulman
Brenda A. Schulman Max Planck Society
Jianping Jin
Jianping Jin Zhejiang University
Alec C. Kimmelman
Alec C. Kimmelman New York University
Wolfram Goessling
Wolfram Goessling Brigham and Women's Hospital
Yang Shi
Yang Shi University of Oxford
Peter M. Howley
Peter M. Howley Harvard Medical School

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