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Biology and Biochemistry

D-Index
52
Citations
12104
World Ranking
16545
National Ranking
1153

Overview

Dorothee Günzel is affiliated with Charité - University Medicine Berlin in Germany. The core of their research focuses on the structure and functions of biological barriers, particularly investigating tight junctions and claudins, which are critical in maintaining paracellular ion flux and cellular homeostasis.

Their recent scholarly output includes publications in several scientific venues, emphasizing molecular biology and physiology related to barrier functions. Notable papers include:

  • "Nanoscale segregation of channel and barrier claudins enables paracellular ion flux," 2022, Nature Communications
  • "Assembly of Tight Junction Strands: Claudin-10b and Claudin-3 Form Homo-Tetrameric Building Blocks that Polymerise in a Channel-Independent Manner," 2020, Journal of Molecular Biology
  • "The role of claudins in homeostasis," 2023, Nature Reviews Nephrology
  • "Channel functions of claudins in the organization of biological systems," 2020, Biochimica et Biophysica Acta (BBA) - Biomembranes
  • "Imputation-powered whole-exome analysis identifies genes associated with kidney function and disease in the UK Biobank," 2023, Nature Communications

Dorothee Günzel collaborates frequently with several researchers, including Jörg Piontek, Nina Himmerkus, Markus Bleich, Anja Fromm, and Rita Rosenthal. These collaborations have extended the understanding of tight junction architecture, ion channel functions, and kidney-related research.

Their work appears consistently in the following publication venues:

  • Zenodo (CERN European Organization for Nuclear Research)
  • Annals of the New York Academy of Sciences
  • Nature Communications
  • Acta Physiologica
  • International Journal of Molecular Sciences

The primary academic fields for Günzel's research are Neuroscience and Medicine, with significant contributions specifically to the subfields of Neurology and Molecular Biology. They also engage in studies related to Electrical and Electronic Engineering and Nephrology, reflecting an interdisciplinary approach integrating biology and biomedical engineering.

The topics central to Günzel's scientific inquiry include:

  • Barrier Structure and Function Studies
  • Connexins and lens biology
  • Neurological Disease Mechanisms and Treatments
  • Electrical and Bioimpedance Tomography
  • Chronic Kidney Disease and Diabetes
  • Epigenetics and DNA Methylation
  • Neonatal and fetal brain pathology

Best Publications

  • Claudins and the Modulation of Tight Junction Permeability

    Dorothee Günzel;Alan S. L. Yu

  • Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn’s disease

    Sebastian Zeissig;Nataly Bürgel;Dorothee Günzel;Jan Richter

  • E‐cadherin is essential for in vivo epidermal barrier function by regulating tight junctions

    Judith A Tunggal;Iris Helfrich;Annika Schmitz;Heinz Schwarz

  • Microbial butyrate and its role for barrier function in the gastrointestinal tract

    Svenja Plöger;Friederike Stumpff;Gregory B. Penner;Jörg-Dieter Schulzke

  • Claudin-2, a component of the tight junction, forms a paracellular water channel.

    Rita Rosenthal;Susanne Milatz;Susanne M. Krug;Beibei Oelrich

  • Claudins and other tight junction proteins.

    Dorothee Günzel;Michael Fromm

  • Tricellulin Forms a Barrier to Macromolecules in Tricellular Tight Junctions without Affecting Ion Permeability

    Susanne M. Krug;Salah Amasheh;Jan F. Richter;Susanne Milatz

  • Molecular basis for cation selectivity in claudin-2-based paracellular pores: identification of an electrostatic interaction site.

    Alan S.L. Yu;Mary H. Cheng;Susanne Angelow;Dorothee Günzel

  • Claudin-3 acts as a sealing component of the tight junction for ions of either charge and uncharged solutes.

    Susanne Milatz;Susanne M. Krug;Rita Rosenthal;Dorothee Günzel

  • Disease-associated mutations affect intracellular traffic and paracellular Mg2+ transport function of Claudin-16

    P. Jaya Kausalya;Salah Amasheh;Dorothee Günzel;Henrik Wurps

  • Claudin-10 exists in six alternatively spliced isoforms that exhibit distinct localization and function

    Dorothee Günzel;Marchel Stuiver;P. Jaya Kausalya;Lea Haisch

  • In tight junctions, claudins regulate the interactions between occludin, tricellulin and marvelD3, which, inversely, modulate claudin oligomerization

    Jimmi Cording;Johanna Berg;Nadja Käding;Christian Bellmann

  • CNNM2, Encoding a Basolateral Protein Required for Renal Mg2+ Handling, Is Mutated in Dominant Hypomagnesemia

    Marchel Stuiver;Sergio Lainez;Constanze Will;Sara Terryn

  • Claudins of intestine and nephron - a correlation of molecular tight junction structure and barrier function.

    S. Amasheh;M. Fromm;D. Günzel

  • TRPV4-mediated regulation of epithelial permeability

    Bettina Reiter;Robert Kraft;Dorothee Günzel;Sebastian Zeissig

  • The effect of chitosan on transcellular and paracellular mechanisms in the intestinal epithelial barrier.

    Rita Rosenthal;Dorothee Günzel;Caroline Finger;Susanne M. Krug

  • Claudin-17 forms tight junction channels with distinct anion selectivity

    Susanne M. Krug;Dorothee Günzel;Marcel P. Conrad;Rita Rosenthal

  • Cell polarity-determining proteins Par-3 and PP-1 are involved in epithelial tight junction defects in coeliac disease

    Michael Schumann;Dorothee Günzel;Nataly Buergel;Jan F Richter

  • Charge-selective claudin channels

    Susanne M. Krug;Dorothee Günzel;Marcel P. Conrad;In-Fah M. Lee

  • Two-Path Impedance Spectroscopy for Measuring Paracellular and Transcellular Epithelial Resistance

    Susanne M. Krug;Michael Fromm;Dorothee Günzel

Frequent Co-Authors

Michael Fromm
Michael Fromm Charité - University Medicine Berlin
Jörg-Dieter Schulzke
Jörg-Dieter Schulzke Charité - University Medicine Berlin
Martin Zeitz
Martin Zeitz Charité - University Medicine Berlin
Dominik N. Müller
Dominik N. Müller Max Delbrück Center for Molecular Medicine
Gerd Krause
Gerd Krause Leibniz Institute for Neurobiology
Holger Martens
Holger Martens Freie Universität Berlin
Walter Hunziker
Walter Hunziker Agency for Science, Technology and Research
Otmar Huber
Otmar Huber Friedrich Schiller University Jena
Trinad Chakraborty
Trinad Chakraborty University of Giessen
Ulrich Dobrindt
Ulrich Dobrindt University of Münster

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