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Sachiko Tsukita

Sachiko Tsukita

D-Index & Metrics

Biology and Biochemistry

D-Index
81
Citations
31649
World Ranking
3809
National Ranking
246

Overview

Sachiko Tsukita is affiliated with Osaka University in Japan and has a research profile spanning several intersecting fields of study. Their work primarily focuses on Biochemistry, Genetics and Molecular Biology, Neuroscience, and Medicine. Within these domains, their research covers specialized subfields such as Neurology, Molecular Biology, Cell Biology, Surgery, and Pulmonary and Respiratory Medicine.

The main research topics addressed by Sachiko Tsukita include Barrier Structure and Function Studies, Gut microbiota and health, Neurological Disease Mechanisms and Treatments, RNA Research and Splicing, Advanced Electron Microscopy Techniques and Applications, Electron and X-Ray Spectroscopy Techniques, and Helicobacter pylori-related gastroenterology studies.

Frequent co-authors collaborating with Tsukita include Atsushi Tamura, Hiroo Tanaka, Hiroka Kashihara, Shogo Nakayama, and Kazuto Tsukita.

Key publication venues where Sachiko Tsukita's work has appeared include Scientific Reports, Science Advances, bioRxiv (Cold Spring Harbor Laboratory), Research Square, and Nature Methods. The number of publications in these venues demonstrates an emphasis on multidisciplinary scientific journals.

Recent papers authored or co-authored by Sachiko Tsukita are:

  • "Parallel cryo electron tomography on in situ lamellae" (2022, Nature Methods)
  • "Inactivation of paracellular cation-selective claudin-2 channels attenuates immune-mediated experimental colitis in mice" (2020, Journal of Clinical Investigation)
  • "A short guide to the tight junction" (2024, Journal of Cell Science)
  • "The tight junction protein occludin modulates blood-brain barrier integrity and neurological function after ischemic stroke in mice" (2023, Scientific Reports)
  • "Multicellular modeling of ciliopathy by combining iPS cells and microfluidic airway-on-a-chip technology" (2021, Science Translational Medicine)

Best Publications

  • Occludin: a novel integral membrane protein localizing at tight junctions.

    M Furuse;T Hirase;M Itoh;A Nagafuchi

  • Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions.

    M Furuse;M Itoh;T Hirase;A Nagafuchi

  • ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons.

    S Tsukita;K Oishi;N Sato;J Sagara

  • Rho-Kinase Phosphorylates COOH-terminal Threonines of Ezrin/Radixin/Moesin (ERM) Proteins and Regulates Their Head-to-Tail Association

    Takeshi Matsui;Masato Maeda;Yoshinori Doi;Shigenobu Yonemura

  • ZO-1 and ZO-2 Independently Determine Where Claudins Are Polymerized in Tight-Junction Strand Formation

    Kazuaki Umeda;Junichi Ikenouchi;Sayaka Katahira-Tayama;Kyoko Furuse

  • Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells

    Junichi Ikenouchi;Mikio Furuse;Kyoko Furuse;Hiroyuki Sasaki

  • The 220-kD protein colocalizing with cadherins in non-epithelial cells is identical to ZO-1, a tight junction-associated protein in epithelial cells: cDNA cloning and immunoelectron microscopy.

    M Itoh;A Nagafuchi;S Yonemura;T Kitani-Yasuda

  • Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway.

    M Hirao;N Sato;T Kondo;S Yonemura

  • Ezrin/Radixin/Moesin (ERM) Proteins Bind to a Positively Charged Amino Acid Cluster in the Juxta-Membrane Cytoplasmic Domain of CD44, CD43, and ICAM-2

    Shigenobu Yonemura;Motohiro Hirao;Yoshinori Doi;Nobuyuki Takahashi

  • The FERM domain: A unique module involved in the linkage of cytoplasmic proteins to the membrane

    Athar H. Chishti;Anthony C. Kim;Shirin M. Marfatia;Mohini Lutchman

  • Direct Interaction of the Rho GDP Dissociation Inhibitor with Ezrin/Radixin/Moesin Initiates the Activation of the Rho Small G Protein

    Kazuo Takahashi;Takuya Sasaki;Akiko Mammoto;Kenji Takaishi

  • Cortical actin organization: lessons from ERM (ezrin/radixin/moesin) proteins.

    Sachiko Tsukita;Shigenobu Yonemura

  • Predicted expansion of the claudin multigene family.

    Katsuhiko Mineta;Yasuko Yamamoto;Yasuko Yamamoto;Yuji Yamazaki;Hiroo Tanaka

  • Induction of polarized cell-cell association and retardation of growth by activation of the E-cadherin-catenin adhesion system in a dispersed carcinoma line.

    Mitsuko Watabe;Akira Nagafuchi;Sachiko Tsukita;Masatoshi Takeichi

  • Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain.

    Keisuke Hamada;Toshiyuki Shimizu;Takeshi Matsui;Shoichiro Tsukita

  • A gene family consisting of ezrin, radixin and moesin. Its specific localization at actin filament/plasma membrane association sites.

    N. Sato;N. Funayama;A. Nagafuchi;S. Yonemura

  • Molecular linkage between cadherins and actin filaments in cell-cell adherens junctions.

    Shoichiro Tsukita;Sachiko Tsukita;Akira Nagafuchi;Shigenobu Yonemura

  • ERM proteins: head-to-tail regulation of actin-plasma membrane interaction.

    Sachiko Tsukita;Shigenobu Yonemura;Shoichiro Tsukita

  • The molecular basis of vascular lumen formation in the developing mouse aorta.

    Boris Strilić;Boris Strilić;Tomáš Kučera;Tomáš Kučera;Jan Eglinger;Jan Eglinger;Michael R. Hughes

  • Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family members.

    K Takeuchi;N Sato;H Kasahara;N Funayama

Frequent Co-Authors

Shoichiro Tsukita
Shoichiro Tsukita Kyoto University
Shigenobu Yonemura
Shigenobu Yonemura University of Tokushima
Tetsuo Noda
Tetsuo Noda Japanese Foundation For Cancer Research
Yoshinori Fujiyoshi
Yoshinori Fujiyoshi Nagoya University
Jerrold R. Turner
Jerrold R. Turner Brigham and Women's Hospital
Mikio Furuse
Mikio Furuse The Graduate University for Advanced Studies, SOKENDAI
Toshio Hakoshima
Toshio Hakoshima Nara Institute of Science and Technology
Hiroyuki Sasaki
Hiroyuki Sasaki Jikei University School of Medicine
Akira Nagafuchi
Akira Nagafuchi Nara Medical University
Toshiyuki Shimizu
Toshiyuki Shimizu University of Tokyo

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