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D-Index & Metrics

Biology and Biochemistry

D-Index
85
Citations
50438
World Ranking
3058
National Ranking
191

Overview

Mikio Furuse is affiliated with The Graduate University for Advanced Studies, SOKENDAI in Japan. Their research spans primarily the fields of Biochemistry, Genetics and Molecular Biology, Neuroscience, and Medicine, with particular focus in subfields such as Neurology, Molecular Biology, Cell Biology, Oncology, and Cancer Research.

Their scholarly output covers a diverse range of topics that include Barrier Structure and Function Studies, Connexins and lens biology, Cellular Mechanics and Interactions, Drug Transport and Resistance Mechanisms, Cancer-related molecular mechanisms research, Neurological Disease Mechanisms and Treatments, and Caveolin-1 and cellular processes.

Frequent collaboration is evident with a number of researchers, including:

  • Tetsuhisa Otani
  • T. Sugawara
  • Kyoko Furuse
  • Yasushi Izumi
  • Daniel Sánchez-Taltavull

Their publications have appeared in various venues, with the most frequent being:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Journal of Cell Biology
  • Trends in Cell Biology
  • Journal of Cell Science
  • Cell Structure and Function

Notable recent papers by this researcher include:

  • "Tight Junction Structure and Function Revisited," 2020, Trends in Cell Biology
  • "Occludin and tricellulin facilitate formation of anastomosing tight-junction strand network to improve barrier function," 2021, Molecular Biology of the Cell
  • "A short guide to the tight junction," 2024, Journal of Cell Science
  • "Physiological functions of junctional adhesion molecules (JAMs) in tight junctions," 2020, Biochimica et Biophysica Acta (BBA) - Biomembranes
  • "Nanoscale segregation of channel and barrier claudins enables paracellular ion flux," 2022, Nature Communications

Best Publications

  • Multifunctional strands in tight junctions.

    Shoichiro Tsukita;Mikio Furuse;Masahiko Itoh

  • Occludin: a novel integral membrane protein localizing at tight junctions.

    M Furuse;T Hirase;M Itoh;A Nagafuchi

  • Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin

    Mikio Furuse;Kohji Fujita;Takashi Hiiragi;Kazushi Fujimoto

  • Size-selective loosening of the blood-brain barrier in claudin-5–deficient mice

    Takehiro Nitta;Masaki Hata;Shimpei Gotoh;Yoshiteru Seo

  • Claudin-based tight junctions are crucial for the mammalian epidermal barrier a lesson from claudin-1–deficient mice

    Mikio Furuse;Masaki Hata;Kyoko Furuse;Yoko Yoshida

  • Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands

    Kazumasa Morita;Mikio Furuse;Kazushi Fujimoto;Shoichiro Tsukita

  • Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with the Cooh Termini of Claudins

    Masahiko Itoh;Mikio Furuse;Kazumasa Morita;Koji Kubota

  • Complex Phenotype of Mice Lacking Occludin, a Component of Tight Junction Strands

    Mitinori Saitou;Mikio Furuse;Hiroyuki Sasaki;Jörg-Dieter Schulzke

  • A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblasts.

    Mikio Furuse;Hiroyuki Sasaki;Kazushi Fujimoto;Shoichiro Tsukita

  • Endothelial Claudin: Claudin-5/Tmvcf Constitutes Tight Junction Strands in Endothelial Cells

    Kazumasa Morita;Hiroyuki Sasaki;Mikio Furuse;Shoichiro Tsukita

  • Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions.

    M Furuse;M Itoh;T Hirase;A Nagafuchi

  • Manner of Interaction of Heterogeneous Claudin Species within and between Tight Junction Strands

    Mikio Furuse;Hiroyuki Sasaki;Shoichiro Tsukita

  • Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney I cells.

    Mikio Furuse;Kyoko Furuse;Hiroyuki Sasaki;Shoichiro Tsukita

  • ZO-1 and ZO-2 Independently Determine Where Claudins Are Polymerized in Tight-Junction Strand Formation

    Kazuaki Umeda;Junichi Ikenouchi;Sayaka Katahira-Tayama;Kyoko Furuse

  • Occludin is a functional component of the tight junction

    Karin M. McCarthy;Ilze B. Skare;Michael C. Stankewich;Mikio Furuse

  • Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells

    Junichi Ikenouchi;Mikio Furuse;Kyoko Furuse;Hiroyuki Sasaki

  • Regulation of tight junctions during the epithelium-mesenchyme transition:direct repression of the gene expression of claudins/occludin by Snail

    Junichi Ikenouchi;Miho Matsuda;Mikio Furuse;Shoichiro Tsukita

  • Clostridium perfringens enterotoxin fragment removes specific claudins from tight junction strands: Evidence for direct involvement of claudins in tight junction barrier.

    Noriyuki Sonoda;Mikio Furuse;Hiroyuki Sasaki;Shigenobu Yonemura

  • Possible Involvement of Phosphorylation of Occludin in Tight Junction Formation

    Akira Sakakibara;Mikio Furuse;Mitinori Saitou;Yuhko Ando-Akatsuka

  • Occludin and claudins in tight-junction strands: leading or supporting players?

    Shoichiro Tsukita;Mikio Furuse

Frequent Co-Authors

Shoichiro Tsukita
Shoichiro Tsukita Kyoto University
Hiroyuki Sasaki
Hiroyuki Sasaki Jikei University School of Medicine
Mitinori Saitou
Mitinori Saitou Kyoto University
Sachiko Tsukita
Sachiko Tsukita Osaka University
Hiroyuki Sasaki
Hiroyuki Sasaki Kyushu University
Rémy Bruggmann
Rémy Bruggmann University of Bern
Gert Lubec
Gert Lubec Paracelsus Medical University
Osamu Yoshie
Osamu Yoshie Kindai University
Masayuki Amagai
Masayuki Amagai Keio University
Christer Betsholtz
Christer Betsholtz Uppsala University

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