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Biology and Biochemistry

D-Index
62
Citations
11784
World Ranking
10957
National Ranking
749

Overview

Hideki Chiba is affiliated with Fukushima Medical University in Japan and specializes in research spanning biochemistry, genetics, molecular biology, medicine, and neuroscience. Their work encompasses various subfields including neurology, molecular biology, cancer research, pulmonary and respiratory medicine, and oncology.

The scientist focuses on research topics that include barrier structure and function studies, cancer-related molecular mechanisms, connexins and lens biology, caveolin-1 and cellular processes, ferroptosis and cancer prognosis, neurological disease mechanisms and treatments, as well as cancer cells and metastasis.

Several recent publications illustrate the scope of their research. These include:

  • Occludin and tricellulin facilitate formation of anastomosing tight-junction strand network to improve barrier function, 2021, Molecular Biology of the Cell
  • Prognostic Significance of Aberrant Claudin-6 Expression in Endometrial Cancer, 2020, Cancers
  • Aberrant Claudin-6-Adhesion Signaling Promotes Endometrial Cancer Progression via Estrogen Receptor α, 2021, Molecular Cancer Research
  • EpCAM proteolysis and release of complexed claudin-7 repair and maintain the tight junction barrier, 2022, The Journal of Cell Biology
  • The claudin-transcription factor signaling pathway, 2021, Tissue Barriers

Frequent publishing venues for Hideki Chiba comprise bioRxiv (Cold Spring Harbor Laboratory), Cancers, Scientific Reports, International Journal of Molecular Sciences, and Cell Communication and Signaling.

The scientist collaborates with several frequent co-authors including Kotaro Sugimoto, Tomohito Higashi, Atsuko Y. Higashi, Makoto Kobayashi, and Akira Saitō.

Best Publications

  • Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase

    Daniel Metzger;John Clifford;Hideki Chiba;Pierre Chambon

  • Transmembrane proteins of tight junctions.

    Hideki Chiba;Makoto Osanai;Masaki Murata;Takashi Kojima

  • Tight junctions and human diseases.

    Norimasa Sawada;Masaki Murata;Keisuke Kikuchi;Makoto Osanai

  • Tight junction proteins claudin-2 and -12 are critical for vitamin D-dependent Ca2+ absorption between enterocytes.

    Hiroki Fujita;Kotaro Sugimoto;Shuichiro Inatomi;Toshihiro Maeda

  • Glial cell line-derived neurotrophic factor induces barrier function of endothelial cells forming the blood-brain barrier.

    Yo Igarashi;Hiroyuki Utsumi;Hideki Chiba;Yumiko Yamada-Sasamori

  • Possible involvement of gap junctions in the barrier function of tight junctions of brain and lung endothelial cells

    Kunihiko Nagasawa;Hideki Chiba;Hiroki Fujita;Takashi Kojima

  • RXR-alpha ablation in skin keratinocytes results in alopecia and epidermal alterations.

    Mei Li;Hideki Chiba;Xavier Warot;Nadia Messaddeq

  • Differential Expression and Subcellular Localization of Claudin-7, −8, −12, −13, and −15 Along the Mouse Intestine

    Hiroki Fujita;Hideki Chiba;Hiroshi Yokozaki;Naoyuki Sakai

  • Cyclic AMP induces phosphorylation of claudin-5 immunoprecipitates and expression of claudin-5 gene in blood–brain-barrier endothelial cells via protein kinase A-dependent and -independent pathways

    Tsutomu Ishizaki;Hideki Chiba;Takashi Kojima;Masato Fujibe

  • Evidence for auto/paracrine actions of vitamin D in bone: 1α-hydroxylase expression and activity in human bone cells

    M. van Driel;M. Koedam;C. J. Buurman;M. Hewison

  • Mouse P450RAI (CYP26) Expression and Retinoic Acid-inducible Retinoic Acid Metabolism in F9 Cells Are Regulated by Retinoic Acid Receptor γ and Retinoid X Receptor α

    Suzan S. Abu-Abed;Barbara R. Beckett;Hideki Chiba;James V. Chithalen

  • Evidence that both 1α,25-dihydroxyvitamin D3 and 24-hydroxylated D3 enhance human osteoblast differentiation and mineralization

    M. van Driel;M. Koedam;C.J. Buurman;M. Roelse

  • Reduced expression of claudin-7 correlates with invasion and metastasis in squamous cell carcinoma of the esophagus.

    Yu Usami;Hideki Chiba;Fumihito Nakayama;Junya Ueda

  • Ghrelin and unacylated ghrelin stimulate human osteoblast growth via mitogen-activated protein kinase (MAPK)/phosphoinositide 3-kinase (PI3K) pathways in the absence of GHS-R1a

    P J D Delhanty;B C J van der Eerden;M van der Velde;C Gauna

  • Thr203 of claudin-1, a putative phosphorylation site for MAP kinase, is required to promote the barrier function of tight junctions.

    Masato Fujibe;Hideki Chiba;Takashi Kojima;Tamotsu Soma

  • Thr207 of claudin-5 is involved in size-selective loosening of the endothelial barrier by cyclic AMP

    Tamotsu Soma;Hideki Chiba;Yuko Kato-Mori;Takuro Wada

  • RXRalpha-null F9 embryonal carcinoma cells are resistant to the differentiation, anti-proliferative and apoptotic effects of retinoids.

    J. Clifford;H. Chiba;D. Sobieszczuk;D. Metzger

  • Epigenetic Silencing of Occludin Promotes Tumorigenic and Metastatic Properties of Cancer Cells via Modulations of Unique Sets of Apoptosis-Associated Genes

    Makoto Osanai;Masaki Murata;Nami Nishikiori;Hideki Chiba

  • Cx32 but not Cx26 is associated with tight junctions in primary cultures of rat hepatocytes.

    Takashi Kojima;Yasuo Kokai;Hideki Chiba;Masao Yamamoto

  • Regulation of the blood-biliary barrier: interaction between gap and tight junctions in hepatocytes.

    Takashi Kojima;Toshinobu Yamamoto;Masaki Murata;Hideki Chiba

Frequent Co-Authors

Norimasa Sawada
Norimasa Sawada Sapporo Medical University
Takashi Kojima
Takashi Kojima Sapporo Medical University
Pierre Chambon
Pierre Chambon Institute of Genetics and Molecular and Cellular Biology
Hiroshi Yokozaki
Hiroshi Yokozaki Kobe University
Koichi Hirata
Koichi Hirata Sapporo Medical University
Harrie Weinans
Harrie Weinans Utrecht University
Jan A.N. Verhaar
Jan A.N. Verhaar Erasmus University Rotterdam
David C. Spray
David C. Spray Albert Einstein College of Medicine
Joost G. J. Hoenderop
Joost G. J. Hoenderop Radboud University
Akiyoshi Kakita
Akiyoshi Kakita Niigata University

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