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Biology and Biochemistry

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Medicine

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Overview

Sylvia Christakos is affiliated with Rutgers, The State University of New Jersey in the United States. Their research primarily focuses on vitamin D and its role in human health, especially related to intestinal physiology and endocrine functions. The scientist has contributed extensively to understanding the genomic and cellular actions of vitamin D, exploring its regulatory mechanisms in both human and animal models.

Their publication record includes multiple recent papers, highlighting different aspects of vitamin D metabolism and its physiological impacts. Notable papers include:

  • New aspects of vitamin D metabolism and action - addressing the skin as source and target, 2020, Nature Reviews Endocrinology
  • Drivers of transcriptional variance in human intestinal epithelial organoids, 2021, Physiological Genomics
  • Vitamin D: A Critical Regulator of Intestinal Physiology, 2021, JBMR Plus
  • Analysis of 1,25-Dihydroxyvitamin D3 Genomic Action Reveals Calcium-Regulating and Calcium-Independent Effects in Mouse Intestine and Human Enteroids, 2020, Molecular and Cellular Biology
  • Genomic analysis of 1,25-dihydroxyvitamin D3 action in mouse intestine reveals compartment and segment-specific gene regulatory effects, 2022, Journal of Biological Chemistry

Christakos's research spans several main fields of study including Medicine and Biochemistry, Genetics and Molecular Biology. Within these domains, their work addresses subfields such as Pathology and Forensic Medicine, Genetics, Molecular Biology, Nephrology, and Nutrition and Dietetics.

The main topics covered in their studies reflect a strong focus on:

  • Vitamin D Research Studies
  • Digestive system and related health
  • Parathyroid Disorders and Treatments
  • Cancer Cells and Metastasis
  • Genetic factors in colorectal cancer
  • Epigenetics and DNA Methylation
  • Bone health and osteoporosis research

Frequent publication venues for Sylvia Christakos include JBMR Plus, Journal of Biological Chemistry, and Frontiers in Endocrinology among others. Their collaborations feature a consistent group of co-authors, including James C. Fleet, Daniel D. Bikle, Michael P. Verzi, Noah F. Shroyer, and Zachary K. Criss, reflecting a network of researchers focused on vitamin D biology and related fields.

Best Publications

  • Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects.

    Sylvia Christakos;Puneet Dhawan;Annemieke Verstuyf;Lieve Verlinden

  • Vitamin D: metabolism.

    Sylvia Christakos;Dare V. Ajibade;Puneet Dhawan;Adam J. Fechner

  • Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis

    Bin Cheng;Sylvia Christakos;Mark P. Mattson

  • 1,25-Dihydroxyvitamin D 3 ameliorates Th17 autoimmunity via transcriptional modulation of interleukin-17A

    Sneha Joshi;Luiz Carlos Pantalena;Xikui K. Liu;Sarah L. Gaffen;Sarah L. Gaffen

  • Vitamin D-dependent calcium binding proteins: Chemistry, distribution, functional considerations, and molecular biology

    Sylvia Christakos;Christine Gabrielides;William B. Rhoten

  • Specific reduction of calcium-binding protein (28-kilodalton calbindin-D) gene expression in aging and neurodegenerative diseases.

    Anthony M. Iacopino;Sylvia Christakos

  • New insights into the mechanisms of vitamin D action.

    Sylvia Christakos;Puneet Dhawan;Yan Liu;Xiaorong Peng

  • Deficient mineralization of intramembranous bone in vitamin D-24-hydroxylase-ablated mice is due to elevated 1,25-dihydroxyvitamin D and not to the absence of 24,25-dihydroxyvitamin D.

    René St-Arnaud;Alice Arabian;Rose Travers;Frank Barletta

  • Induction of cathelicidin in normal and CF bronchial epithelial cells by 1,25-dihydroxyvitamin D3

    Sunghan Yim;Puneet Dhawan;Chandran Ragunath;Sylvia Christakos

  • Calcium buffering properties of calbindin D28k and parvalbumin in rat sensory neurones.

    P S Chard;D Bleakman;S Christakos;C S Fullmer

  • Vitamin D: beyond bone

    Sylvia Christakos;Martin Hewison;David G. Gardner;Carol L. Wagner

  • Vitamin D and Intestinal Calcium Absorption

    Sylvia Christakos;Puneet Dhawan;Angela Porta;Leila J. Mady

  • Vitamin D, calcium homeostasis and aging

    Vaishali Veldurthy;Ran Wei;Leyla Oz;Puneet Dhawan

  • Calcium Transporter 1 and Epithelial Calcium Channel Messenger Ribonucleic Acid Are Differentially Regulated by 1,25 Dihydroxyvitamin D3 in the Intestine and Kidney of Mice

    Yurong Song;Xiaorong Peng;Angela Porta;Hitomi Takanaga

  • 1,25-Dihydroxyvitamin D3 and pancreatic beta-cell function: vitamin D receptors, gene expression, and insulin secretion.

    Sooja Lee;Samuel A. Clark;Rajbir K. Gill;Sylvia Christakos

  • Mechanisms Underlying the Regulation of Innate and Adaptive Immunity by Vitamin D

    Ran Wei;Sylvia Christakos

  • Genomic mechanisms involved in the pleiotropic actions of 1,25-dihydroxyvitamin D3

    Sylvia Christakos;Mihali Raval-Pandya;Roman P. Wernyj;Wen Yang

  • New aspects of vitamin D metabolism and action - addressing the skin as source and target.

    Daniel Bikle;Daniel Bikle;Sylvia Christakos

  • Calbindin D28k Blocks the Proapoptotic Actions of Mutant Presenilin 1: Reduced Oxidative Stress and Preserved Mitochondrial Function

    Qing Guo;Sylvia Christakos;Nic Robinson;Mark P. Mattson

  • Studies on the mode of action of calciferol. XIII. Development of a radioimmunoassay for vitamin D-dependent chick intestinal calcium-binding protein and tissue distribution.

    Sylvia Christakos;Ernest J. Friedlander;Brad R. Frandsen;Anthony W. Norman

Frequent Co-Authors

Daniel D. Bikle
Daniel D. Bikle University of California, San Francisco
Mark P. Mattson
Mark P. Mattson Johns Hopkins University
J. Wesley Pike
J. Wesley Pike University of Wisconsin–Madison
Matthias A. Hediger
Matthias A. Hediger University of Bern
Noah F. Shroyer
Noah F. Shroyer Baylor College of Medicine
Hector F. DeLuca
Hector F. DeLuca University of Wisconsin–Madison
Allan J. Tobin
Allan J. Tobin University of California, Los Angeles
John S. Adams
John S. Adams University of California, Los Angeles
David Feldman
David Feldman Stanford University

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