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Akiyoshi Kakita

Akiyoshi Kakita

D-Index & Metrics

Neuroscience

D-Index
81
Citations
25315
World Ranking
1566
National Ranking
32

Overview

Akiyoshi Kakita is a researcher affiliated with Niigata University in Japan. Their work spans multiple fields including Medicine and Biochemistry, Genetics and Molecular Biology, with a significant focus on areas such as Neurology, Molecular Biology, and Genetics. Within these fields, they have published extensively on subfields like Cellular and Molecular Neuroscience and Physiology.

The research contributions of Akiyoshi Kakita cover diverse topics primarily related to neurological and genetic disorders. Key areas of investigation include:

  • Alzheimer's disease research and treatments
  • Parkinson's Disease mechanisms and treatments
  • Glioma diagnosis and treatment
  • Amyotrophic Lateral Sclerosis research
  • Genetic neurodegenerative diseases
  • Neurological disorders and treatments
  • Neurogenetic and muscular disorders research

Kakita has coauthored publications with a number of frequent collaborators, including Mari Tada, Osamu Onodera, Hiroshi Shimizu, Manabu Natsumeda, and Makoto Oishi.

Publication venues where Kakita's work appears most frequently include:

  • Neuropathology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Acta Neuropathologica Communications
  • Neuropathology and Applied Neurobiology
  • Journal of Neuropathology & Experimental Neurology

Selected recent papers by Akiyoshi Kakita encompass a range of studies in neurological research:

  • "Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease" (2020), Nature Medicine
  • "Structure-based classification of tauopathies" (2021), Nature
  • "Versatile whole-organ/body staining and imaging based on electrolyte-gel properties of biological tissues" (2020), Nature Communications
  • "Cytosolic dsDNA of mitochondrial origin induces cytotoxicity and neurodegeneration in cellular and zebrafish models of Parkinson's disease" (2021), Nature Communications
  • "Comparison of Common and Disease-Specific Post-translational Modifications of Pathological Tau Associated With a Wide Range of Tauopathies" (2020), Frontiers in Neuroscience

This profile reflects an academic focus on molecular and cellular mechanisms underlying neurological diseases, as well as methodological advances in biological tissue imaging and analysis. The combination of clinical, genetic, and molecular approaches represented in Kakita's work provides insights relevant to multiple neurodegenerative conditions.

Best Publications

  • Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease

    Yingyue Zhou;Wilbur M. Song;Prabhakar S. Andhey;Amanda Swain

  • Structure-based classification of tauopathies

    Yang Shi;Wenjuan Zhang;Yang Yang;Alexey G. Murzin

  • Loss of aquaporin 4 in lesions of neuromyelitis optica: distinction from multiple sclerosis.

    T. Misu;K. Fujihara;A. Kakita;H. Konno

  • Axonal α-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease

    Satoshi Orimo;Toshiki Uchihara;Ayako Nakamura;Fumiaki Mori

  • Accumulation of alpha-synuclein/NACP is a cytopathological feature common to Lewy body disease and multiple system atrophy.

    K. Wakabayashi;Shintaro Hayashi;Akiyoshi Kakita;Mitsunori Yamada

  • TDP-43 mutation in familial amyotrophic lateral sclerosis

    Akio Yokoseki;Atsushi Shiga;Chun-Feng Tan;Asako Tagawa

  • TDP-43 immunoreactivity in neuronal inclusions in familial amyotrophic lateral sclerosis with or without SOD1 gene mutation.

    Chun-Feng Tan;Hiroto Eguchi;Asako Tagawa;Osamu Onodera

  • Chemical Landscape for Tissue Clearing Based on Hydrophilic Reagents.

    Kazuki Tainaka;Tatsuya C. Murakami;Etsuo A. Susaki;Chika Shimizu

  • Increased L1 Retrotransposition in the Neuronal Genome in Schizophrenia

    Miki Bundo;Manabu Toyoshima;Yohei Okada;Wado Akamatsu

  • Degeneration of Cardiac Sympathetic Nerve Begins in the Early Disease Process of Parkinson’s Disease

    Satoshi Orimo;Atsushi Takahashi;Toshiki Uchihara;Fumiaki Mori

  • Expansions of intronic TTTCA and TTTTA repeats in benign adult familial myoclonic epilepsy.

    Hiroyuki Ishiura;Koichiro Doi;Jun Mitsui;Jun Yoshimura

  • Versatile whole-organ/body staining and imaging based on electrolyte-gel properties of biological tissues

    Etsuo A. Susaki;Chika Shimizu;Akihiro Kuno;Akihiro Kuno;Kazuki Tainaka

  • Patterns and Dynamics of SVZ Cell Migration in the Postnatal Forebrain: Monitoring Living Progenitors in Slice Preparations

    Akiyoshi Kakita;James E. Goldman

  • Neuropathology with clinical correlations of sporadic amyotrophic lateral sclerosis: 102 autopsy cases examined between 1962 and 2000.

    Yue-Shan Piao;Koichi Wakabayashi;Akiyoshi Kakita;Mitsunori Yamada

  • Profound downregulation of the RNA editing enzyme ADAR2 in ALS spinal motor neurons.

    Takuto Hideyama;Takenari Yamashita;Hitoshi Aizawa;Shoji Tsuji

  • Isolation and Characterization of Patient-derived, Toxic, High Mass Amyloid β-Protein (Aβ) Assembly from Alzheimer Disease Brains

    Akihiko Noguchi;Satoko Matsumura;Mari Dezawa;Mari Dezawa;Mari Tada

  • Somatic Mutations in the MTOR gene cause focal cortical dysplasia type IIb

    Mitsuko Nakashima;Hirotomo Saitsu;Nobuyuki Takei;Jun Tohyama

  • Evaluation of changes in methylmercury accumulation in the developing rat brain and its effects: a study with consecutive and moderate dose exposure throughout gestation and lactation periods.

    Mineshi Sakamoto;Akiyoshi Kakita;Koichi Wakabayashi;Hitoshi Takahashi

  • Sporadic amyotrophic lateral sclerosis: two pathological patterns shown by analysis of distribution of TDP-43-immunoreactive neuronal and glial cytoplasmic inclusions.

    Yasushi Nishihira;Chun-Feng Tan;Osamu Onodera;Yasuko Toyoshima

  • Cognitive impairment and cortical degeneration in neuromyelitis optica.

    Etsuji Saji;Musashi Arakawa;Kaori Yanagawa;Yasuko Toyoshima

  • Brain Cannabinoid CB2 Receptor in Schizophrenia

    Hiroki Ishiguro;Yasue Horiuchi;Maya Ishikawa;Minori Koga

Frequent Co-Authors

Yukihiko Fujii
Yukihiko Fujii Niigata University
Hiroyuki Nawa
Hiroyuki Nawa Wakayama Medical University
Shoji Tsuji
Shoji Tsuji University of Tokyo
Yoshikazu Ugawa
Yoshikazu Ugawa Fukushima Medical University
Tsutomu Nakada
Tsutomu Nakada Niigata University
Toshiki Uchihara
Toshiki Uchihara Tokyo Metropolitan Institute of Medical Science
Michel Goedert
Michel Goedert MRC Laboratory of Molecular Biology
Hidehiro Mizusawa
Hidehiro Mizusawa Tokyo Medical and Dental University
Mitsuhiro Kato
Mitsuhiro Kato Showa University
Tadao Arinami
Tadao Arinami University of Tsukuba

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