Takeshi Ikeuchi

Overview

Best Publications

• Unstable expansion of CAG repeat in hereditary dentatorubral–pallidoluysian atrophy (DRPLA)

  R. Koide;T. Ikeuchi;O. Onodera;H. Tanaka

  1384
  Citations

• Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease

  Yingyue Zhou;Wilbur M. Song;Prabhakar S. Andhey;Amanda Swain

  1109
  Citations

• Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease

  Oliver Preische;Oliver Preische;Stephanie A. Schultz;Anja Apel;Anja Apel;Jens Kuhle

  903
  Citations

• Identification of the spinocerebellar ataxia type 2 gene using a direct identification of repeat expansion and cloning technique, DIRECT.

  K Sanpei;H Takano;S Igarashi;T Sato

  894
  Citations

• Structure-based classification of tauopathies

  Yang Shi;Wenjuan Zhang;Yang Yang;Alexey G. Murzin

  882
  Citations

• A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease.

  Nicolas R Barthélemy;Yan Li;Nelly Joseph-Mathurin;Brian A Gordon

  614
  Citations

• Association of HTRA1 mutations and familial ischemic cerebral small-vessel disease

  Shoji Tsuji;Osamu Onodera

  603
  Citations

• Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription.

  Takayoshi Shimohata;Toshihiro Nakajima;Mitsunori Yamada;Chiharu Uchida

  491
  Citations

• TDP-43 mutation in familial amyotrophic lateral sclerosis

  Akio Yokoseki;Atsushi Shiga;Chun-Feng Tan;Asako Tagawa

  461
  Citations

• A Neurological Disease Caused By an Expanded CAG Trinucleotide Repeat in The TATA-Binding Protein Gene: A New Polyglutamine Disease?

  Reiji Koide;Shigeichi Kobayashi;Takayoshi Shimohata;Takeshi Ikeuchi

  459
  Citations

• Novel tau filament fold in corticobasal degeneration

  Wenjuan Zhang;Airi Tarutani;Kathy L. Newell;Alexey G. Murzin

  457
  Citations

• Suppression of aggregate formation and apoptosis by transglutaminase inhibitors in cells expressing truncated DRPLA protein with an expanded polyglutamine stretch.

  Shuichi Igarashi;Reiji Koide;Takayoshi Shimohata;Mitsunori Yamada

  408
  Citations

• Close Associations between Prevalences of Dominantly Inherited Spinocerebellar Ataxias with CAG-Repeat Expansions and Frequencies of Large Normal CAG Alleles in Japanese and Caucasian Populations

  H. Takano;G. Cancel;T. Ikeuchi;D. Lorenzetti

  299
  Citations

• Characterization of a Presenilin-mediated Amyloid Precursor Protein Carboxyl-terminal Fragment γ EVIDENCE FOR DISTINCT MECHANISMS INVOLVED IN γ-SECRETASE PROCESSING OF THE APP AND Notch1 TRANSMEMBRANE DOMAINS

  Chunjiang Yu;Seong-Hun Kim;Takeshi Ikeuchi;Huaxi Xu

  297
  Citations

• The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage.

  Takeshi Ikeuchi;Sangram S. Sisodia

  284
  Citations

• Japanese Families with Autosomal Dominant Pure Cerebellar Ataxia Map to Chromosome 19p13.1-p13.2 and Are Strongly Associated with Mild CAG Expansions in the Spinocerebellar Ataxia Type 6 Gene in Chromosome 19p13.1

  K. Ishikawa;H. Tanaka;M. Saito;N. Ohkoshi

  195
  Citations

• Dentatorubral‐pallidoluysian atrophy: Clinical features are closely related to unstable expansions of trinucleotide (CAG) repeat

  Ikeuchi T;Koide R;Tanaka H;Onodera O

  192
  Citations

• SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians

  Akinori Miyashita;Asako Koike;Gyungah Jun;Li-San Wang

  183
  Citations

• CSF1R-related leukoencephalopathy: A major player in primary microgliopathies

  Takuya Konno;Koji Kasanuki;Takeshi Ikeuchi;Dennis W. Dickson

  164
  Citations

• Transgenic Mice Harboring a Full-Length Human Mutant DRPLA Gene Exhibit Age-Dependent Intergenerational and Somatic Instabilities of CAG repeats Comparable with Those in DRPLA patients

  Toshiya Sato;Mutsuo Oyake;Kenji Nakamura;Kazuki Nakao

  160
  Citations