The study of Presenilin, Tau protein and Amyloid precursor protein are components of his Alzheimer's disease research. His study connects Internal medicine and Amyloid precursor protein. His Presenilin research extends to Internal medicine, which is thematically connected. Disease is closely attributed to Dementia in his study. His Dementia study frequently links to other fields, such as Disease. Takeshi Ikeuchi performs multidisciplinary study in the fields of Gene and Molecular biology via his papers. Takeshi Ikeuchi carries out multidisciplinary research, doing studies in Molecular biology and Gene. Takeshi Ikeuchi regularly ties together related areas like Gene expression in his Genetics studies. His Pathology study frequently links to other fields, such as Amyloid (mycology).
Takeshi Ikeuchi has begun a study into Gene, looking into Mutation and Allele. He connects Mutation with Gene in his research. Takeshi Ikeuchi regularly ties together related areas like Neurodegeneration in his Disease studies. Neurodegeneration and Disease are commonly linked in his work. Takeshi Ikeuchi regularly ties together related areas like Atrophy in his Pathology studies. He frequently studies issues relating to Pathology and Atrophy. Takeshi Ikeuchi combines Genetics and Allele in his research. He incorporates Internal medicine and Psychiatry in his research. While working on this project, he studies both Psychiatry and Internal medicine.
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Unstable expansion of CAG repeat in hereditary dentatorubral–pallidoluysian atrophy (DRPLA)
R. Koide;T. Ikeuchi;O. Onodera;H. Tanaka.
Nature Genetics (1994)
Identification of the spinocerebellar ataxia type 2 gene using a direct identification of repeat expansion and cloning technique, DIRECT.
K Sanpei;H Takano;S Igarashi;T Sato.
Nature Genetics (1996)
Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription.
Takayoshi Shimohata;Toshihiro Nakajima;Mitsunori Yamada;Chiharu Uchida.
Nature Genetics (2000)
TDP-43 mutation in familial amyotrophic lateral sclerosis
Akio Yokoseki;Atsushi Shiga;Chun-Feng Tan;Asako Tagawa.
Annals of Neurology (2008)
A Neurological Disease Caused By an Expanded CAG Trinucleotide Repeat in The TATA-Binding Protein Gene: A New Polyglutamine Disease?
Reiji Koide;Shigeichi Kobayashi;Takayoshi Shimohata;Takeshi Ikeuchi.
Human Molecular Genetics (1999)
Suppression of aggregate formation and apoptosis by transglutaminase inhibitors in cells expressing truncated DRPLA protein with an expanded polyglutamine stretch.
Shuichi Igarashi;Reiji Koide;Takayoshi Shimohata;Mitsunori Yamada.
Nature Genetics (1998)
Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease
Yingyue Zhou;Wilbur M. Song;Prabhakar S. Andhey;Amanda Swain.
Nature Medicine (2020)
Characterization of a Presenilin-mediated Amyloid Precursor Protein Carboxyl-terminal Fragment γ EVIDENCE FOR DISTINCT MECHANISMS INVOLVED IN γ-SECRETASE PROCESSING OF THE APP AND Notch1 TRANSMEMBRANE DOMAINS
Chunjiang Yu;Seong-Hun Kim;Takeshi Ikeuchi;Huaxi Xu.
Journal of Biological Chemistry (2001)
Close Associations between Prevalences of Dominantly Inherited Spinocerebellar Ataxias with CAG-Repeat Expansions and Frequencies of Large Normal CAG Alleles in Japanese and Caucasian Populations
H. Takano;G. Cancel;T. Ikeuchi;D. Lorenzetti.
American Journal of Human Genetics (1998)
The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage.
Takeshi Ikeuchi;Sangram S. Sisodia.
Journal of Biological Chemistry (2003)
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