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Osamu Onodera

Osamu Onodera

D-Index & Metrics

Biology and Biochemistry

D-Index
79
Citations
19244
World Ranking
4386
National Ranking
287

Overview

Osamu Onodera is affiliated with Niigata University in Japan and has an extensive research profile primarily within the fields of Medicine, Neuroscience, and Biochemistry, Genetics, and Molecular Biology. Their work spans key subfields such as Neurology, Molecular Biology, Cellular and Molecular Neuroscience, Genetics, and Physiology.

The main topics of Onodera's research focus on Genetic Neurodegenerative Diseases, Amyotrophic Lateral Sclerosis Research, Parkinson's Disease Mechanisms and Treatments, Neurogenetic and Muscular Disorders Research, Mitochondrial Function and Pathology, Cerebrovascular and Genetic Disorders, and Neurological Diseases and Metabolism.

Onodera has contributed to numerous scholarly articles published in several recurring venues. These include Rinsho Shinkeigaku with 9 publications, bioRxiv (Cold Spring Harbor Laboratory) contributing 8 papers, Acta Neuropathologica Communications with 6 publications, Neurology also with 6, and the Journal of the Neurological Sciences with 5 papers.

Frequent coauthors collaborating with Onodera are Masato Kanazawa, Akiyoshi Kakita, Tomohiko Ishihara, Takeshi Ikeuchi, and Masahiro Uemura, reflecting sustained scholarly partnerships within related research areas.

Selected recent publications from Onodera's research record include:

  • Safety and efficacy of tilavonemab in progressive supranuclear palsy: a phase 2, randomised, placebo-controlled trial, 2021, The Lancet Neurology
  • HTRA1-Related Cerebral Small Vessel Disease: A Review of the Literature, 2020, Frontiers in Neurology
  • Cytosolic dsDNA of mitochondrial origin induces cytotoxicity and neurodegeneration in cellular and zebrafish models of Parkinson's disease, 2021, Nature Communications
  • TDP-43 transports ribosomal protein mRNA to regulate axonal local translation in neuronal axons, 2020, Acta Neuropathologica
  • Efficacy and Safety of Ultrahigh-Dose Methylcobalamin in Early-Stage Amyotrophic Lateral Sclerosis, 2022, JAMA Neurology

Best Publications

  • Unstable expansion of CAG repeat in hereditary dentatorubral–pallidoluysian atrophy (DRPLA)

    R. Koide;T. Ikeuchi;O. Onodera;H. Tanaka

  • Association of HTRA1 mutations and familial ischemic cerebral small-vessel disease

    Shoji Tsuji;Osamu Onodera

  • Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription.

    Takayoshi Shimohata;Toshihiro Nakajima;Mitsunori Yamada;Chiharu Uchida

  • TDP-43 mutation in familial amyotrophic lateral sclerosis

    Akio Yokoseki;Atsushi Shiga;Chun-Feng Tan;Asako Tagawa

  • The gene for Machado–Joseph disease maps to human chromosome 14q

    Y Takiyama;M Nishizawa;H Tanaka;S Kawashima

  • Mutations in COQ2 in familial and sporadic multiple-system atrophy the multiple-system atrophy research collaboration

    Jun Mitsui;Takashi Matsukawa;Hiroyuki Ishiura;Yoko Fukuda;Yoko Fukuda

  • Early-onset ataxia with ocular motor apraxia and hypoalbuminemia is caused by mutations in a new HIT superfamily gene

    Hidetoshi Date;Osamu Onodera;Hajime Tanaka;Kiyoshi Iwabuchi

  • TDP-43 immunoreactivity in neuronal inclusions in familial amyotrophic lateral sclerosis with or without SOD1 gene mutation.

    Chun-Feng Tan;Hiroto Eguchi;Asako Tagawa;Osamu Onodera

  • Expansions of intronic TTTCA and TTTTA repeats in benign adult familial myoclonic epilepsy.

    Hiroyuki Ishiura;Koichiro Doi;Jun Mitsui;Jun Yoshimura

  • Demyelinating and axonal features of Charcot–Marie–Tooth disease with mutations of myelin‐related proteins (PMP22, MPZ and Cx32): a clinicopathological study of 205 Japanese patients

    Naoki Hattori;Masahiko Yamamoto;Tsuyoshi Yoshihara;Haruki Koike

  • Soluble polyglutamine oligomers formed prior to inclusion body formation are cytotoxic.

    Toshiaki Takahashi;Shinya Kikuchi;Shinichi Katada;Yoshitaka Nagai

  • Strong correlation between the number of CAG repeats in androgen receptor genes and the clinical onset of features of spinal and bulbar muscular atrophy

    S. Igarashi;Y. Tanno;O. Onodera;M. Yamazaki

  • Genetic association of the very low density lipoprotein (VLDL) receptor gene with sporadic Alzheimer's disease.

    Kaoru Okuizumi;Osamu Onodera;Yoshio Namba;Kazuhiko Ikeda

  • Sporadic amyotrophic lateral sclerosis: two pathological patterns shown by analysis of distribution of TDP-43-immunoreactive neuronal and glial cytoplasmic inclusions.

    Yasushi Nishihira;Chun-Feng Tan;Osamu Onodera;Yasuko Toyoshima

  • Aprataxin, a novel protein that protects against genotoxic stress

    Nuri Gueven;Olivier J. Becherel;Amanda W. Kijas;Philip Chen

  • β-Synuclein gene alterations in dementia with Lewy bodies

    H. Ohtake;P. Limprasert;Y. Fan;O. Onodera

  • Dentatorubral‐pallidoluysian atrophy: Clinical features are closely related to unstable expansions of trinucleotide (CAG) repeat

    Ikeuchi T;Koide R;Tanaka H;Onodera O

  • Polyglutamine Diseases: Where Does Toxicity Come From? What Is Toxicity? Where Are We Going?

    Toshiaki Takahashi;Shinichi Katada;Osamu Onodera

  • Early Development of Autonomic Dysfunction May Predict Poor Prognosis in Patients With Multiple System Atrophy

    Mari Tada;Osamu Onodera;Masayoshi Tada;Tetsutaro Ozawa

  • ERBB4 Mutations that Disrupt the Neuregulin-ErbB4 Pathway Cause Amyotrophic Lateral Sclerosis Type 19

    Yuji Takahashi;Yoko Fukuda;Jun Yoshimura;Atsushi Toyoda

Frequent Co-Authors

Shoji Tsuji
Shoji Tsuji University of Tokyo
Takeshi Ikeuchi
Takeshi Ikeuchi Niigata University
Akiyoshi Kakita
Akiyoshi Kakita Niigata University
Kazuyoshi Takayama
Kazuyoshi Takayama Tohoku University
Hitoshi Takahashi
Hitoshi Takahashi Niigata University
Gen Sobue
Gen Sobue Aichi Medical University
Ryozo Kuwano
Ryozo Kuwano Niigata University
Koichi Wakabayashi
Koichi Wakabayashi Hirosaki University
James R. Burke
James R. Burke Duke University

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