James R. Burke

Overview

Best Publications

• Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

  Adam C. Naj;Gyungah Jun;Gary W. Beecham;Li-San Wang

  2280
  Citations

• Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines

  Alexander V. Panov;Claire-Anne Gutekunst;Blair R. Leavitt;Michael R. Hayden

  1267
  Citations

• Prevalence of cognitive impairment without dementia in the United States.

  Brenda L. Plassman;Kenneth M. Langa;Gwenith G. Fisher;Steven G. Heeringa

  1258
  Citations

• Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

  Rebecca Sims;Sven J. Van Der Lee;Adam C. Naj;Céline Bellenguez;Céline Bellenguez

  1090
  Citations

• Documented head injury in early adulthood and risk of Alzheimer’s disease and other dementias

  Brenda L. Plassman;R. J. Havlik;D. C. Steffens;M. J. Helms

  1053
  Citations

• Systematic review: factors associated with risk for and possible prevention of cognitive decline in later life.

  Brenda L. Plassman;John W. Williams;James R. Burke;Tracey Holsinger

  830
  Citations

• BMS-345541 Is a Highly Selective Inhibitor of IκB Kinase That Binds at an Allosteric Site of the Enzyme and Blocks NF-κB-dependent Transcription in Mice

  James R. Burke;Mark A. Pattoli;Kurt R. Gregor;Patrick J. Brassil

  748
  Citations

• Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH.

  James R. Burke;Jan J. Enghild;Margaret E. Martin;Yuh Shan Jou

  587
  Citations

• Metabolomics in early Alzheimer's disease: identification of altered plasma sphingolipidome using shotgun lipidomics.

  Xianlin Han;Steve Rozen;Stephen H. Boyle;Caroline Hellegers

  468
  Citations

• Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study

  Eric M Reiman;Joseph F Arboleda-Velasquez;Yakeel T Quiroz;Matthew J Huentelman

  461
  Citations

• Preventing Alzheimer's disease and cognitive decline.

  John W Williams;B L Plassman;J Burke;S Benjamin

  446
  Citations

• Risk of dementia among relatives of Alzheimer's disease patients in the MIRAGE study What is in store for the oldest old?

  N. T. Lautenschlager;L. A. Cupples;V. S. Rao;S. A. Auerbach

  434
  Citations

• Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis

  David C. Whitcomb;Jessica LaRusch;Alyssa M. Krasinskas;Lambertus Klei

  405
  Citations

• A novel human disease with abnormal prion protein sensitive to protease

  Pierluigi Gambetti;Zhiqian Dong;Jue Yuan;Xiangzhu Xiao

  359
  Citations

• Risk Factors and Preventive Interventions for Alzheimer Disease: State of the Science

  Martha L. Daviglus;Brenda L. Plassman;Amber Pirzada;Carl C. Bell

  356
  Citations

• A novel Alzheimer disease locus located near the gene encoding tau protein

  G. Jun;C. A. Ibrahim-Verbaas;M. Vronskaya;J-C Lambert;J-C Lambert;J-C Lambert

  322
  Citations

• Duration and Intensity of NF-κB Activity Determine the Severity of Endotoxin-Induced Acute Lung Injury

  M. Brett Everhart;Wei Han;Taylor P. Sherrill;Melissa Arutiunov

  315
  Citations

• IKK mediates ischemia-induced neuronal death.

  Oliver Herrmann;Bernd Baumann;Rossana de Lorenzi;Sajjad Muhammad

  314
  Citations

• A highly selective inhibitor of I kappa B kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice.

  Kim W. McIntyre;David J. Shuster;Kathleen M. Gillooly;Donna M. Dambach

  303
  Citations

• Specificity, sensitivity, and predictive value of apolipoprotein-E genotyping for sporadic Alzheimer's disease

  A. M. Saunders;C. Hulette;K. A. Welsh-Bohmer;D. E. Schmechel

  295
  Citations