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Christine M. Hulette

Christine M. Hulette

D-Index & Metrics

Medicine

D-Index
86
Citations
39637
World Ranking
13886
National Ranking
7051

Overview

Christine M. Hulette is a researcher affiliated with Duke University in the United States. Their work intersects multiple fields, prominently within Medicine and Biochemistry, Genetics, and Molecular Biology. This multidisciplinary approach supports their focus on neurological and genetic conditions.

Their research covers subfields including Genetics, Molecular Biology, Physiology, Neurology, and Ophthalmology. These areas reflect the scientific breadth of their investigations, which also encompass key medical topics such as Alzheimer's disease research and treatments, genetic associations and epidemiology, bioinformatics and genomic networks, machine learning in bioinformatics, amyotrophic lateral sclerosis research, genetics and neurodevelopmental disorders, and dementia and cognitive impairment research.

Among their recent publications are:

  • Manifestations of Alzheimer's disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90 (2022), Scientific Reports
  • LATE-NC risk alleles (in TMEM106B, GRN, and ABCC9 genes) among persons with African ancestry (2023), Journal of Neuropathology & Experimental Neurology
  • Amyloid-β predominant Alzheimer's disease neuropathologic change (2024), Brain
  • Performance of Polygenic Risk Scores for Primary Open-Angle Glaucoma in Populations of African Descent (2024), JAMA Ophthalmology

Christine M. Hulette has frequently published in venues such as Scientific Reports, Journal of Neuropathology & Experimental Neurology, Brain, and JAMA Ophthalmology, indicating active engagement with journals specializing in neurology, neuropathology, and ophthalmology.

They have collaborated multiple times with several coauthors, demonstrating ongoing scientific partnerships. These frequent collaborators include Nilüfer Ertekin-Taner, David W. Fardo, Liana G. Apostolova, Lisa L. Barnes, and Eileen H. Bigio.

Best Publications

  • Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease.

    A. M. Saunders;W. J. Strittmatter;D. Schmechel;P. H. St. George-Hyslop

  • Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

    Peter T Nelson;Irina Alafuzoff;Eileen H Bigio;Constantin Bouras

  • Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

    Adam C. Naj;Gyungah Jun;Gary W. Beecham;Li-San Wang

  • Analysis of shared heritability in common disorders of the brain

    Verneri Anttila;Verneri Anttila;Brendan Bulik-Sullivan;Brendan Bulik-Sullivan;Hilary K. Finucane;Raymond K. Walters;Raymond K. Walters

  • Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease

    D E Schmechel;A M Saunders;W J Strittmatter;B J Crain

  • Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

    Rebecca Sims;Sven J. Van Der Lee;Adam C. Naj;Céline Bellenguez;Céline Bellenguez

  • Neuropathology of nondemented aging: Presumptive evidence for preclinical Alzheimer disease

    Joseph L. Price;Daniel W. McKeel;Virginia D. Buckles;Catherine M. Roe

  • Region-specific neurotrophin imbalances in Alzheimer disease: decreased levels of brain-derived neurotrophic factor and increased levels of nerve growth factor in hippocampus and cortical areas.

    Christoph Hock;Klaus Heese;Christine Hulette;Carlyn Rosenberg

  • Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons.

    Winnie S. Liang;Eric M. Reiman;Jon Valla;Travis Dunckley

  • Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

    Vivianna M. Van Deerlin;Patrick M A Sleiman;Maria Martinez-Lage;Maria Martinez-Lage;Alice Chen-Plotkin

  • CD36, a Class B Scavenger Receptor, Is Expressed on Microglia in Alzheimer's Disease Brains and Can Mediate Production of Reactive Oxygen Species in Response to β-Amyloid Fibrils

    Indra Sethy Coraci;Jens Husemann;Joan W. Berman;Christine Hulette

  • Hypothesis: Microtubule Instability and Paired Helical Filament Formation in the Alzheimer Disease Brain Are Related to Apolipoprotein E Genotype

    Warren J. Strittmatter;Karl H. Weisgraber;Michel Goedert;Ann M. Saunders

  • Microvascular injury and blood-brain barrier leakage in Alzheimer's disease.

    B.D. Zipser;C.E. Johanson;L. Gonzalez;T.M. Berzin

  • Ganglioside-induced differentiation-associated protein-1 is mutant in Charcot-Marie-Tooth disease type 4A/8q21

    Rachel V. Baxter;Kamel Ben Othmane;Julie M. Rochelle;Jason E. Stajich

  • FDG PET Imaging in Patients with Pathologically Verified Dementia

    J. M. Hoffman;K. A. Welsh-Bohmer;M. Hanson;B. Crain

  • Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis

    David C. Whitcomb;Jessica LaRusch;Alyssa M. Krasinskas;Lambertus Klei

  • Neuropathological and Neuropsychological Changes in “Normal” Aging: Evidence for Preclinical Alzheimer Disease in Cognitively Normal Individuals

    Christine M. Hulette;Kathleen A. Welsh-Bohmer;Michael G. Murray;Ann M. Saunders

  • Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set

    Winnie S. Liang;Travis Dunckley;Thomas G. Beach;Andrew Grover

  • A novel human disease with abnormal prion protein sensitive to protease

    Pierluigi Gambetti;Zhiqian Dong;Jue Yuan;Xiangzhu Xiao

  • α2-Adrenergic receptors in human spinal cord: specific localized expression of mRNA encoding α2-adrenergic receptor subtypes at four distinct levels ☆

    Mark Stafford Smith;Uta B. Schambra;Katrina H. Wilson;Stella O. Page

Frequent Co-Authors

Margaret A. Pericak-Vance
Margaret A. Pericak-Vance University of Miami
James R. Burke
James R. Burke Duke University
Ann M. Saunders
Ann M. Saunders Durham University
John C. Morris
John C. Morris Washington University in St. Louis
Eric M. Reiman
Eric M. Reiman Arizona State University
Philip L. De Jager
Philip L. De Jager Columbia University
John R. Gilbert
John R. Gilbert University of Miami
Walter A. Kukull
Walter A. Kukull University of Washington
Bernardino Ghetti
Bernardino Ghetti Indiana University

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