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Bernardino Ghetti

Bernardino Ghetti

D-Index & Metrics

Medicine

D-Index
133
Citations
82570
World Ranking
2189
National Ranking
1236

Research.com Recognitions

  • 2013 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1999 - Sedgwick Memorial Medal, American Public Health Association
  • 1999 - Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases, American Academy of Neurology

Overview

Bernardino Ghetti is affiliated with Indiana University in the United States and has contributed extensively to research in medicine, biochemistry, genetics, and molecular biology. Their scholarly work spans physiology, neurology, molecular biology, psychiatry and mental health, and genetics, with a strong focus on neurological diseases and neurodegenerative conditions.

Their research topics cover a range of areas including:

  • Alzheimer's disease research and treatments
  • Prion diseases and protein misfolding
  • Parkinson's disease mechanisms and treatments
  • Dementia and cognitive impairment research
  • Neurological diseases and metabolism
  • Amyotrophic lateral sclerosis research
  • Functional brain connectivity studies

Ghetti has published in a variety of venues, frequently contributing to the following:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Alzheimer s & Dementia
  • Acta Neuropathologica
  • Nature
  • EMPIAR dataset

They have also co-authored work with frequently collaborating researchers including Kathy L. Newell, Rubén Vidal, Michel Goedert, Holly J. Garringer, and Sjors H. W. Scheres.

Selected recent publications include:

  • Structure-based classification of tauopathies, 2021, Nature
  • Structures of α-synuclein filaments from multiple system atrophy, 2020, Nature
  • Novel tau filament fold in corticobasal degeneration, 2020, Nature
  • Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study, 2020, Nature Communications
  • Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture, 2021, Nature Genetics

In addition to journal articles, Ghetti has contributed to books published by Springer Nature, including the title Frontotemporal Dementias (2021).

Throughout their career, Ghetti has been recognized with several awards. These include election as a Fellow of the American Association for the Advancement of Science (AAAS) in 2013, the Sedgwick Memorial Medal from the American Public Health Association in 1999, and the Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases awarded by the American Academy of Neurology in 1999.

Best Publications

  • Clinical and Biomarker Changes in Dominantly Inherited Alzheimer’s Disease

    Randall J. Bateman;Chengjie Xiong;Tammie L.S. Benzinger;Anne M. Fagan

  • Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

    Adam C. Naj;Gyungah Jun;Gary W. Beecham;Li-San Wang

  • Cryo-EM structures of tau filaments from Alzheimer’s disease

    Anthony W. P. Fitzpatrick;Benjamin Falcon;Shaoda He;Alexey G. Murzin

  • Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

    Maria Grazia Spillantini;Jill R. Murrell;Michel Goedert;Martin R. Farlow

  • Classification of sporadic Creutzfeldt‐Jakob disease based on molecular and phenotypic analysis of 300 subjects

    Piero Parchi;Armin Giese;Sabina Capellari;Paul Brown

  • A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease.

    Jill Murrell;Martin Farlow;Bernardino Ghetti;Merrill D. Benson

  • Molecular basis of phenotypic variability in sporadic Creutzfeldt-Jakob disease.

    Piero Parchi;Rudolph Castellani;Sabina Capellari;Bernardino Ghetti

  • Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update

    Ian R. A. Mackenzie;Manuela Neumann;Eileen H. Bigio;Nigel J. Cairns

  • Aβ42‐driven cerebral amyloidosis in transgenic mice reveals early and robust pathology

    Rebecca Radde;Tristan Bolmont;Stephan A Kaeser;Janaky Coomaraswamy

  • Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

    Rebecca Sims;Sven J. Van Der Lee;Adam C. Naj;Céline Bellenguez;Céline Bellenguez

  • Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition.

    Kelly R. Bales;Tatyana Verina;Richard C. Dodel;Richard C. Dodel;Yansheng Du

  • Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease

    Oliver Preische;Oliver Preische;Stephanie A. Schultz;Anja Apel;Anja Apel;Jens Kuhle

  • Abundant Tau Filaments and Nonapoptotic Neurodegeneration in Transgenic Mice Expressing Human P301S Tau Protein

    Bridget Allen;Esther Ingram;Masaki Takao;Michael J. Smith

  • The National Alzheimer's Coordinating Center (NACC) database: the Uniform Data Set.

    Duane L. Beekly;Erin M. Ramos;William W. Lee;Woodrow D. Deitrich

  • Structures of filaments from Pick's disease reveal a novel tau protein fold

    Benjamin Falcon;Wenjuan Zhang;Alexey G. Murzin;Garib Murshudov

  • Brain homogenates from human tauopathies induce tau inclusions in mouse brain.

    Florence Clavaguera;Hiroyasu Akatsu;Graham Fraser;R. Anthony Crowther

  • Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy

    Günter U. Höglinger;Nadine M. Melhem;Dennis W. Dickson;Patrick M A Sleiman

  • Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease.

    Kelly R. Bales;Tatyana Verina;David J. Cummins;Yansheng Du

  • [EC-03–02]: CRYO-EM STRUCTURES OF TAU FILAMENTS FROM ALZHEIMER'S DISEASE BRAIN

    Anthony Fitzpatrick;Benjamin Falcon;Shaoda He;Alexey Murzin

  • TRANSMISSION AND SPREADING OF TAUOPATHIES IN TRANSGENIC MOUSE BRAIN

    Florence Clavaguera;Bernardino Ghetti;Gabriel Schweighauser;Hiroyasu Akatsu

Frequent Co-Authors

Martin R. Farlow
Martin R. Farlow Indiana University
Pedro Piccardo
Pedro Piccardo University of Edinburgh
John C. Morris
John C. Morris Washington University in St. Louis
Fabrizio Tagliavini
Fabrizio Tagliavini Istituto Neurologico Carlo Besta
Peter R. Schofield
Peter R. Schofield Neuroscience Research Australia
Andrew J. Saykin
Andrew J. Saykin Indiana University
Randall J. Bateman
Randall J. Bateman Washington University in St. Louis
Richard Mayeux
Richard Mayeux Columbia University
Alison Goate
Alison Goate Icahn School of Medicine at Mount Sinai

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