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Daniel J. Tschumperlin

Daniel J. Tschumperlin

D-Index & Metrics

Biology and Biochemistry

D-Index
66
Citations
16369
World Ranking
8630
National Ranking
3873

Overview

Daniel J. Tschumperlin is affiliated with the Mayo Clinic in the United States and specializes in fields related to Medicine and Biochemistry, Genetics, and Molecular Biology. Their research primarily focuses on pulmonary and respiratory medicine, with significant contributions to interstitial lung diseases and idiopathic pulmonary fibrosis.

Their recent published works include:

  • Mechano-therapeutics: Targeting Mechanical Signaling in Fibrosis and Tumor Stroma (2020, Pharmacology & Therapeutics)
  • Extracellular matrix stiffness determines DNA repair efficiency and cellular sensitivity to genotoxic agents (2020, Science Advances)
  • Dysfunctional ERG signaling drives pulmonary vascular aging and persistent fibrosis (2022, Nature Communications)
  • Vascular dysfunction in aged mice contributes to persistent lung fibrosis (2020, Aging Cell)
  • Targeting GPCR Signaling for Idiopathic Pulmonary Fibrosis Therapies (2020, Trends in Pharmacological Sciences)

Tschumperlin's research topics include:

  • Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
  • Neonatal Respiratory Health Research
  • Pulmonary Hypertension Research and Treatments
  • Hippo pathway signaling and YAP/TAZ
  • Medical Imaging and Pathology Studies
  • Cellular Mechanics and Interactions
  • Uterine Myomas and Treatments

Frequent coauthors collaborating on their publications are:

  • Jeffrey A. Meridew
  • Patrick A. Link
  • Nunzia Caporarello
  • Andrew J. Haak
  • Kyoung Moo Choi

Their works are often published in notable journals, with multiple publications in:

  • American Journal of Physiology-Lung Cellular and Molecular Physiology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • American Journal of Respiratory Cell and Molecular Biology
  • American Journal of Respiratory and Critical Care Medicine
  • Nature Communications

Key subfields of study in Tschumperlin's research include pulmonary and respiratory medicine, molecular biology, cell biology, surgery, and cardiology and cardiovascular medicine. Their research integrates cellular mechanics and signaling pathways with clinical aspects of lung diseases, targeting mechanisms that influence fibrosis, vascular dysfunction, and cellular responses to injury.

Best Publications

  • Cellular senescence mediates fibrotic pulmonary disease

    Marissa J. Schafer;Thomas A. White;Koji Iijima;Andrew J. Haak

  • Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression.

    Fei Liu;Justin D. Mih;Barry S. Shea;Alvin T. Kho;Alvin T. Kho

  • Universal physical responses to stretch in the living cell

    Xavier Trepat;Linhong Deng;Linhong Deng;Steven S. An;Steven S. An;Daniel Navajas

  • Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis.

    Fei Liu;David Lagares;Kyoung Moo Choi;Lauren Stopfer

  • Unjamming and cell shape in the asthmatic airway epithelium

    Jin Ah Park;Jae Hun Kim;Dapeng Bi;Jennifer A. Mitchel

  • Matrix Rigidity Regulates Cancer Cell Growth and Cellular Phenotype

    Robert W. Tilghman;Catharine R. Cowan;Justin D. Mih;Yulia Koryakina

  • Deformation-induced injury of alveolar epithelial cells. Effect of frequency, duration, and amplitude.

    Daniel J. Tschumperlin;Jane Oswari;And Susan S. Margulies

  • Mechanotransduction through growth-factor shedding into the extracellular space

    Daniel J. Tschumperlin;Guohao Dai;Ivan V. Maly;Tadashi Kikuchi

  • Mechanical stress is communicated between different cell types to elicit matrix remodeling

    M. A. Swartz;D. J. Tschumperlin;R. D. Kamm;J. M. Drazen

  • TRPV4 mediates myofibroblast differentiation and pulmonary fibrosis in mice

    Shaik O. Rahaman;Lisa M. Grove;Sailaja Paruchuri;Brian D. Southern

  • Alveolar epithelial surface area-volume relationship in isolated rat lungs.

    Daniel J. Tschumperlin;Susan S. Margulies

  • Cell Elasticity Determines Macrophage Function

    Naimish R. Patel;Medhavi Bole;Cheng Chen;Cheng Chen;Charles Corey Hardin

  • Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report.

    Timothy S. Blackwell;Andrew M. Tager;Zea Borok;Bethany B. Moore

  • Extracellular matrix in lung development, homeostasis and disease

    Yong Zhou;Jeffrey C. Horowitz;Alexandra Naba;Namasivayam Ambalavanan

  • Equibiaxial deformation-induced injury of alveolar epithelial cells in vitro

    Daniel J. Tschumperlin;Susan S. Margulies

  • Mechanosensing and fibrosis

    Daniel J. Tschumperlin;Giovanni Ligresti;Moira B. Hilscher;Vijay H. Shah

  • Mechanical properties of cultured human airway smooth muscle cells from 0.05 to 0.4 Hz.

    Geoffrey N. Maksym;Ben Fabry;James P. Butler;Daniel Navajas

  • Matrix stiffness reverses the effect of actomyosin tension on cell proliferation

    Justin D. Mih;Aleksandar Marinkovic;Fei Liu;Asma S. Sharif

  • Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis

    David Lagares;Alba Santos;Paula E. Grasberger;Fei Liu

  • Chronic effects of mechanical force on airways.

    Daniel J. Tschumperlin;Jeffrey M. Drazen

Frequent Co-Authors

Jeffrey M. Drazen
Jeffrey M. Drazen Harvard University
Jeffrey J. Fredberg
Jeffrey J. Fredberg Harvard University
Andrew M. Tager
Andrew M. Tager Harvard University
Y. S. Prakash
Y. S. Prakash Mayo Clinic
James P. Butler
James P. Butler Harvard University
Tamas Ordog
Tamas Ordog Mayo Clinic
Eric S. White
Eric S. White University of Michigan–Ann Arbor
Victor J. Thannickal
Victor J. Thannickal Tulane University
Raul Urrutia
Raul Urrutia Medical College of Wisconsin

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