Fabrizio Manetti

Overview

Best Publications

• MmpL3 Is the Cellular Target of the Antitubercular Pyrrole Derivative BM212

  Valentina La Rosa;Giovanna Poce;Julio Ortiz Canseco;Silvia Buroni

  246
  Citations

• Synthesis, biological evaluation, and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis: part 2. Synthesis of rigid pyrazolones.

  Daniele Castagnolo;Fabrizio Manetti;Marco Radi;Beatrice Bechi

  211
  Citations

• Synthesis, biological evaluation, and pharmacophore generation of new pyridazinone derivatives with affinity toward alpha(1)- and alpha(2)-adrenoceptors.

  Roberta Barbaro;Laura Betti;Maurizio Botta;Federico Corelli

  168
  Citations

• Synthesis, biological evaluation and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis

  Daniele Castagnolo;Alessandro De Logu;Marco Radi;Beatrice Bechi

  164
  Citations

• Antimycobacterial agents. Novel diarylpyrrole derivatives of BM212 endowed with high activity toward Mycobacterium tuberculosis and low cytotoxicity.

  Mariangela Biava;Giulio Cesare Porretta;Giovanna Poce;Sibilla Supino

  152
  Citations

• LIM kinases are attractive targets with many macromolecular partners and only a few small molecule regulators

  Fabrizio Manetti

  139
  Citations

• Antimycobacterial compounds. New pyrrole derivatives of BM212

  Mariangela Biava;Giulio Cesare Porretta;Delia Deidda;Raffaello Pompei

  120
  Citations

• Fibroblast growth factors and their inhibitors.

  Fabrizio Manetti;Federico Corelli;Maurizio Botta

  119
  Citations

• Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection.

  Giovanna Poce;Robert H. Bates;Salvatore Alfonso;Martina Cocozza

  117
  Citations

• New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation

  Silvia Schenone;Olga Bruno;Angelo Ranise;Francesco Bondavalli

  116
  Citations

• Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation.

  Fabio Carraro;Antonella Naldini;Annalisa Pucci;Giada A. Locatelli

  112
  Citations

• Importance of the thiomorpholine introduction in new pyrrole derivatives as antimycobacterial agents analogues of BM 212.

  Mariangela Biava;Giulio Cesare Porretta;Delia Deidda;Raffaello Pompei

  105
  Citations

• 1,5-Diphenylpyrrole derivatives as antimycobacterial agents. Probing the influence on antimycobacterial activity of lipophilic substituents at the phenyl rings.

  Mariangela Biava;Giulio Cesare Porretta;Giovanna Poce;Alessandro De Logu

  104
  Citations

• Toward the discovery of novel anti-HIV drugs. Second-generation inhibitors of the cellular ATPase DDX3 with improved anti-HIV activity: synthesis, structure-activity relationship analysis, cytotoxicity studies, and target validation.

  Giovanni Maga;Federico Falchi;Marco Radi;Lorenzo Botta

  104
  Citations

• Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity.

  Antonio Solinas;Hélène Faure;Hermine Roudaut;Elisabeth Traiffort

  103
  Citations

• Identification of a novel pyrazolo[3,4-d]pyrimidine able to inhibit cell proliferation of a human osteogenic sarcoma in vitro and in a xenograft model in mice.

  Fabrizio Manetti;Annalisa Santucci;Giada A. Locatelli;Giovanni Maga

  101
  Citations

• Antifungal agents. 10. New derivatives of 1-[(aryl)[4-aryl-1H-pyrrol-3-yl]methyl]-1H-imidazole, synthesis, anti-candida activity, and quantitative structure-analysis relationship studies.

  Andrea Tafi;Roberta Costi;Maurizio Botta;Roberto Di Santo

  101
  Citations

• Synthesis and evaluation of new Hsp90 inhibitors based on a 1,4,5-trisubstituted 1,2,3-triazole scaffold

  Maurizio Taddei;Serena Ferrini;Luca Giannotti;Massimo Corsi

  100
  Citations

• Computational comparison of microtubule-stabilising agents laulimalide and peloruside with taxol and colchicine.

  Oriol Pineda;Jaume Farràs;Laura Maccari;Fabrizio Manetti

  100
  Citations

• 4-Hydroxyphenylpyruvate Dioxygenase and Its Inhibition in Plants and Animals: Small Molecules as Herbicides and Agents for the Treatment of Human Inherited Diseases

  Annalisa Santucci;Giulia Bernardini;Daniela Braconi;Elena Petricci

  98
  Citations

• Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: Towards the next generation HIV-1 inhibitors

  Marco Radi;Federico Falchi;Anna Garbelli;Alberta Samuele

  95
  Citations

• Synthesis, biological evaluation and docking studies of 4-amino substituted 1H-pyrazolo[3,4-d]pyrimidines.

  Silvia Schenone;Chiara Brullo;Olga Bruno;Francesco Bondavalli

  94
  Citations