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Chemistry
India
2025

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Chemistry

D-Index
71
Citations
20362
World Ranking
5477
National Ranking
58

Research.com Recognitions

  • 2025 - Research.com Chemistry in India Leader Award
  • 2022 - Research.com Chemistry in India Leader Award

Overview

Dharmarajan Sriram is affiliated with the Birla Institute of Technology and Science, Pilani in India. Their research primarily spans the fields of chemistry, biochemistry, genetics and molecular biology, and medicine. Within these broad disciplines, their work has strong emphasis on organic chemistry, molecular biology, infectious diseases, materials chemistry, and pharmacology.

The scientist's research topics consistently focus on synthesis and biological activity, tuberculosis research and epidemiology, cancer therapeutics and mechanisms, synthesis and biological evaluation, phenothiazines and benzothiazines synthesis and activities, quinazolinone synthesis and applications, and click chemistry and applications.

Notable recent publications by Dharmarajan Sriram include:

  • Regio- and diastereoselective synthesis of spiropyrroloquinoxaline grafted indole heterocyclic hybrids and evaluation of their anti-Mycobacterium tuberculosis activity, 2020, RSC Advances
  • Stereoselective synthesis and discovery of novel spirooxindolopyrrolidine engrafted indandione heterocyclic hybrids as antimycobacterial agents, 2021, Bioorganic Chemistry
  • Novel isoniazid embedded triazole derivatives: Synthesis, antitubercular and antimicrobial activity evaluation, 2020, Bioorganic & Medicinal Chemistry Letters
  • Novel pyrazine based anti-tubercular agents: Design, synthesis, biological evaluation and in silico studies, 2020, Bioorganic Chemistry
  • Pyrazole-coumarin and pyrazole-quinoline chalcones as potential antitubercular agents, 2020, Archiv der Pharmazie

Frequent coauthors collaborating with Sriram include Vagolu Siva Krishna, Estharla Madhu Rekha, Jyothi Kumari, Srinivas Kantevari, and Balasubramanian Sridhar.

Their research is often published in several key scientific journals such as:

  • Bioorganic Chemistry
  • Archiv der Pharmazie
  • The Cambridge Structural Database
  • Journal of Molecular Structure
  • Bioorganic & Medicinal Chemistry Letters

Dharmarajan Sriram's body of work covers synthesis techniques and the biological evaluation of novel compounds targeting tuberculosis and related infectious diseases, with substantial contributions to cancer therapeutics and the chemistry of heterocyclic compounds.

Best Publications

  • Synthesis, antibacterial, antifungal and anti-HIV activities of Schiff and Mannich bases derived from isatin derivatives and N-[4-(4′-chlorophenyl)thiazol-2-yl] thiosemicarbazide

    S.N. Pandeya;D. Sriram;G. Nath;E. DeClercq

  • Betulinic Acid and Its Derivatives: A Review on their Biological Properties

    Perumal Yogeeswari;Dharmarajan Sriram

  • Synthesis and evaluation of anti-HIV activity of isatin β-thiosemicarbazone derivatives

    Tanushree Ratan Bal;Balasubramani Anand;Perumal Yogeeswari;Dharmarajan Sriram

  • Synthesis and antimicrobial activity of Schiff and Mannich bases of isatin and its derivatives with pyrimidine

    S.N Pandeya;D Sriram;G Nath;E De Clercq

  • Synthesis, antibacterial, antifungal and anti-HIV evaluation of Schiff and Mannich bases of isatin derivatives with 3-amino-2-methylmercapto quinazolin-4(3H)-one.

    S.N. Pandeya;D. Sriram;G. Nath;E. De Clercq

  • Design and synthesis of anticonvulsants from a combined phthalimide-GABA-anilide and hydrazone pharmacophore.

    Jegadeesan Vaigunda Ragavendran;Dharmarajan Sriram;Sravan Kumar Patel;Ingala Vikram Reddy

  • Synthesis, antibacterial, antifungal and anti-HIV activities of norfloxacin mannich bases.

    Surendra N Pandeya;Dhamrajan Sriram;Gopal Nath;Erik De Clercq

  • Design, Synthesis, and Structure–Activity Correlations of Novel Dibenzo[b,d]furan, Dibenzo[b,d]thiophene, and N-Methylcarbazole Clubbed 1,2,3-Triazoles as Potent Inhibitors of Mycobacterium tuberculosis

    Santhosh Reddy Patpi;Lokesh Pulipati;Perumal Yogeeswari;Dharmarajan Sriram

  • Discovery of antimycobacterial spiro-piperidin-4-ones: an atom economic, stereoselective synthesis, and biological intervention.

    Raju Ranjith Kumar;Subbu Perumal;Palaniappan Senthilkumar;Perumal Yogeeswari

  • Synthesis, Antibacterial, Antifungal and Anti-HIV Evaluation of Schiff and Mannich Bases of Isatin and its Derivatives with Triazole

    Surendra N Pandeya;Dharmarajan Sriram;Gopal Nath;Erik de Clercq

  • Synthesis and in vitro and in vivo antimycobacterial activity of isonicotinoyl hydrazones

    Dharmarajan Sriram;Perumal Yogeeswari;Kasinathan Madhu

  • Abacavir prodrugs: Microwave-assisted synthesis and their evaluation of anti-HIV activities

    Dharmarajan Sriram;Perumal Yogeeswari;Naga Sirisha Myneedu;Vivek Saraswat

  • Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies

    P Ebbesen;E O Pettersen;T A Gorr;G Jobst

  • Camptothecin and its analogues: a review on their chemotherapeutic potential.

    Dharmarajan Sriram;Perumal Yogeeswari;Rathinasabapathy Thirumurugan;Tanushree Ratan Bal

  • A facile synthesis and antimycobacterial evaluation of novel spiro-pyrido-pyrrolizines and pyrrolidines.

    Raju Ranjith Kumar;Subbu Perumal;Palaniappan Senthilkumar;Perumal Yogeeswari

  • An atom efficient, solvent-free, green synthesis and antimycobacterial evaluation of 2-amino-6-methyl-4-aryl-8-[(E)-arylmethylidene]-5,6,7,8-tetrahydro-4H-pyrano[3,2-c]pyridine-3-carbonitriles.

    Raju Ranjith Kumar;Subbu Perumal;Palaniappan Senthilkumar;Perumal Yogeeswari

  • A regio- and stereoselective 1,3-dipolar cycloaddition for the synthesis of novel spiro-pyrrolothiazolyloxindoles and their antitubercular evaluation.

    Pitchaimani Prasanna;Kamaraj Balamurugan;Subbu Perumal;Perumal Yogeeswari

  • Synthesis and in vitro antimycobacterial activity of N1-nicotinoyl-3-(4'-hydroxy-3'-methyl phenyl)-5-[(sub)phenyl]-2-pyrazolines.

    Mohammad Shaharyar;Anees Ahamed Siddiqui;Mohamed Ashraf Ali;Dharmarajan Sriram

  • Novel three-component domino reactions of ketones, isatin and amino acids: Synthesis and discovery of antimycobacterial activity of highly functionalised novel dispiropyrrolidines

    Raju Suresh Kumar;Stephen Michael Rajesh;Subbu Perumal;Debjani Banerjee

  • Discovery of N-(2,6-dimethylphenyl)-substituted semicarbazones as anticonvulsants: hybrid pharmacophore-based design.

    Perumal Yogeeswari;Dharmarajan Sriram;Rathinasabapathy Thirumurugan;Jegadeesan Vaigunda Raghavendran

  • Design, Synthesis, and Evaluation of Thiol-Activated Sources of Sulfur Dioxide (SO2) as Antimycobacterial Agents

    Satish R. Malwal;Dharmarajan Sriram;Perumal Yogeeswari;V. Badireenath Konkimalla

Frequent Co-Authors

Perumal Yogeeswari
Perumal Yogeeswari Birla Institute of Technology and Science, Pilani
James P. Stables
James P. Stables National Institutes of Health
Valakunja Nagaraja
Valakunja Nagaraja Indian Institute of Science
Balasubramanian Sridhar
Balasubramanian Sridhar Indian Institute of Chemical Technology
Christophe Pannecouque
Christophe Pannecouque Rega Institute for Medical Research
Asit K. Chakraborti
Asit K. Chakraborti University of Burdwan
Erik De Clercq
Erik De Clercq Rega Institute for Medical Research
Jan Balzarini
Jan Balzarini KU Leuven
Rajesh G. Gonnade
Rajesh G. Gonnade CSIR – National Institute for Interdisciplinary Science and Technology

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